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BACTOSHAPE

Single cell biophysics of bacterial cell shape

Total Cost €

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EC-Contrib. €

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Partnership

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Project "BACTOSHAPE" data sheet

The following table provides information about the project.

Coordinator
INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT 

Organization address
address: Rue De L'Universite 147
city: PARIS CEDEX 07
postcode: 75338
website: www.inra.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Project website https://www.micalis.fr/Poles-et-Equipes/Pole-Biosys/ProCeD-Carballido-Lopez/Anciens-membres/Benoit-TESSON
 Total cost 185˙076 €
 EC max contribution 185˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2015
 Duration (year-month-day) from 2015-04-01   to  2017-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT FR (PARIS CEDEX 07) coordinator 185˙076.00

Map

 Project objective

In bacteria, the rigid external cell wall (CW) and the intracellular actin-like (MreB) cytoskeleton are major determinants of cell shape. Synthesis and chemical composition of the CW, a three dimensional polymer network that is one of the most prominent targets for antibiotics, are well understood. However, despite decades of study, little is known about the complex CW ultrastructure and the molecular mechanisms that control cell shape in time and space. MreB homologues assemble into dynamic membrane-associated structures thought to control shape by serving as organizers for the movement and assembly of macromolecular machineries responsible for CW biogenesis. However, the mechanistic details used by the MreB cytoskeleton to fulfill this role remain to be elucidated. We will combine powerful genetic tools available in the model Gram-positive bacterium Bacillus subtilis with modern high-resolution fluorescence microscopy techniques and atomic force microscopy (AFM) to study the role of the MreB cytoskeleton and CW synthesis proteins in cell shape determination and maintenance. Additionally, the role of mechanical forces in the control of CW organization will be evaluated.

 Publications

year authors and title journal last update
List of publications.
2017 Alex Dajkovic, Benoit Tesson, Smita Chauhan, Pascal Courtin, Ruth Keary, Pierre Flores, Christian Marlière, Sérgio R. Filipe, Marie-Pierre Chapot-Chartier, Rut Carballido-Lopez
Hydrolysis of peptidoglycan is modulated by amidation of meso -diaminopimelic acid and Mg 2+ in B acillus subtilis
published pages: 972-988, ISSN: 0950-382X, DOI: 10.1111/mmi.13673
Molecular Microbiology 104/6 2019-06-18

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