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PV-COAT SIGNED

PROSTHETIC VALVE BIOACTIVE SURFACE COATING TO REDUCE THE PREVALENCE OF THROMBOSIS

Total Cost €

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EC-Contrib. €

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Partnership

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Project "PV-COAT" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE DE LIEGE 

Organization address
address: PLACE DU 20 AOUT 7
city: LIEGE
postcode: 4000
website: www.ulg.ac.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 2˙367˙055 €
 EC max contribution 2˙367˙055 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-CoG
 Funding Scheme ERC-COG
 Starting year 2015
 Duration (year-month-day) from 2015-09-01   to  2020-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE DE LIEGE BE (LIEGE) coordinator 2˙367˙055.00

Map

 Project objective

Heart valve prostheses are currently among the most widely used cardiovascular devices. To maintain enduring optimal biomechanical properties, the mechanical prostheses, based on carbon, metallic and polymeric components, require permanent anticoagulation, which often leads to adverse reactions, i.e. higher risks of thromboembolism, hemorrhage, and hemolysis.

Continuing advances in heart valve prosthesis design and in techniques for implantation have improved the survival length and quality of life of patients who receive these devices. In an ongoing effort to develop a more durable and biocompatible heart valve prosthesis, researchers have used a variety of techniques to determine the suitability of given valve materials for a given implant application. In recent years, advances in polymer science have given rise to new ways of improving artificial cardiovascular devices biostability and hemocompatibility.

To date, no polymer coated mechanical prosthetic heart valve exists.

The present research project aims to improve the hemocompatibility and long-term in vivo performance of mechanical prosthetic heart valves by reducing contact-induced thrombosis through bioactive polymer prosthetic valve surface coating. These new coated prosthetic heart valves will be designed for hemodynamic performance and durability similar to uncoated materials, combined with a greater thromboresistance, both in vitro and in animal studies.

With these promising advances, bioactive surface coated prosthetic heart valves could replace previous generation of prosthetic valves in the near future. The utmost perspective of the current project paves the way for the development of new bioactive coating for other implantable cardiovascular devices or materials.

 Publications

year authors and title journal last update
List of publications.
2018 Lucia Musumeci, Nicolas Jacques, Alexandre Hego, Alain Nchimi, Patrizio Lancellotti, Cécile Oury
Prosthetic Aortic Valves: Challenges and Solutions
published pages: , ISSN: 2297-055X, DOI: 10.3389/fcvm.2018.00046
Frontiers in Cardiovascular Medicine 5 2019-10-15
2018 Alain Nchimi, John E. Dibato, Laurent Davin, Laurent Schoysman, Cécile Oury, Patrizio Lancellotti
Predicting Disease Progression and Mortality in Aortic Stenosis: A Systematic Review of Imaging Biomarkers and Meta-Analysis
published pages: , ISSN: 2297-055X, DOI: 10.3389/fcvm.2018.00112
Frontiers in Cardiovascular Medicine 5 2019-10-15
2018 Cécile Oury, Alain Nchimi, Patrizio Lancellotti, Jutta Bergler-Klein
Can Blood Biomarkers Help Predicting Outcome in Transcatheter Aortic Valve Implantation?
published pages: , ISSN: 2297-055X, DOI: 10.3389/fcvm.2018.00031
Frontiers in Cardiovascular Medicine 5 2019-10-15
2018 Patrizio Lancellotti, Julien Magne, Raluca Dulgheru, Marie-Annick Clavel, Erwan Donal, Mani A. Vannan, John Chambers, Raphael Rosenhek, Gilbert Habib, Guy Lloyd, Stefano Nistri, Madalina Garbi, Stella Marchetta, Khalil Fattouch, Augustin Coisne, David Montaigne, Thomas Modine, Laurent Davin, Olivier Gach, Marc Radermecker, Shizhen Liu, Linda Gillam, Andrea Rossi, Elena Galli, Federica Ilardi, Lionel Tastet, Romain Capoulade, Robert Zilberszac, E. Mara Vollema, Victoria Delgado, Bernard Cosyns, Stephane Lafitte, Anne Bernard, Luc A. Pierard, Jeroen J. Bax, Philippe Pibarot, Cécile Oury
Outcomes of Patients With Asymptomatic Aortic Stenosis Followed Up in Heart Valve Clinics
published pages: , ISSN: 2380-6583, DOI: 10.1001/jamacardio.2018.3152
JAMA Cardiology 2019-10-15

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