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IntraMEMS

Microfluidic platform for intra-operative tumor immunohistochemistry

Total Cost €

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EC-Contrib. €

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Partnership

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Project "IntraMEMS" data sheet

The following table provides information about the project.

Coordinator
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE 

Organization address
address: BATIMENT CE 3316 STATION 1
city: LAUSANNE
postcode: 1015
website: www.epfl.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 150˙000 €
 EC max contribution 150˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-PoC
 Funding Scheme ERC-POC
 Starting year 2015
 Duration (year-month-day) from 2015-06-01   to  2016-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE CH (LAUSANNE) coordinator 150˙000.00

Map

 Project objective

We propose to develop an automated microfluidic platform for rapid analysis of the margins of frozen resections of tumors. It will allow cancer cells to be specifically distinguished from healthy cells during the time course of the surgical intervention itself via an immunohistochemistry (IHC) staining protocol completed in 5 minutes. The interest of such platform is that late-positivity, which is defined as the detection of cancer cells within the resection margin of the tumor by means of classical IHC after surgery, can be reduced or even avoided. Patients diagnosed with latepositive margins carry a high risk of cancer recurrence due to possible tumor cells left in the body. Intra-operative margin assessment of tumor resections is already done to evaluate the presence of such remaining cancer cells using different techniques. The most common one is microscopic morphological examination by applying hematoxylin and eosin (H&E) staining on cryo-sectioned surgical specimens, because it can be done easily in a matter of minutes. However, the major drawback of this method is the lack of cancer cell-specific staining: the interpretation relies only on morphology and small numbers of cancer cells infiltrating into healthy tissue are not easily recognizable. We therefore will develop a platform that can perform IHC together with H&E staining on cryo-sectioned samples within 5 minutes. Combining IHC that targets cancer cell-specific proteins with H&E staining will show unequivocally the presence of cancer cells and minimize those variations in the outcome of the analysis that originate from the pathologist’s personal interpretation. It will potentially decrease the recurrence rate, increase the success of post-operative treatment, and reduce unnecessary surgical rescissions.

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The information about "INTRAMEMS" are provided by the European Opendata Portal: CORDIS opendata.

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lastchecktime (2022-08-18 5:09:47) correctly updated