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NanoPaths SIGNED

Identifying pathways of cellular nanoparticle uptake and early processing for novel nanomedicine applications

Total Cost €

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EC-Contrib. €

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Partnership

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Project "NanoPaths" data sheet

The following table provides information about the project.

Coordinator
RIJKSUNIVERSITEIT GRONINGEN 

Organization address
address: Broerstraat 5
city: GRONINGEN
postcode: 9712CP
website: www.rug.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 1˙498˙746 €
 EC max contribution 1˙498˙746 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-STG
 Funding Scheme ERC-STG
 Starting year 2015
 Duration (year-month-day) from 2015-07-01   to  2020-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    RIJKSUNIVERSITEIT GRONINGEN NL (GRONINGEN) coordinator 1˙498˙746.00

Map

 Project objective

Nanotechnology applied to medicine has opened tremendous opportunities for the design of devices capable of targeting cancer and other diseases, and to deliver therapies selectively to locations where drugs currently can scarcely arrive. Translation of nanomedicines to the clinic however still remains challenging and the mechanistic details of the pathways used by cells to internalize and process man-made nanoparticles are still poorly understood. NanoPaths aims to understand how nanoparticles are processed by cells and in particular (1) to disentangle the mechanisms they use to enter cells, and (2) discover whether highly curved nanosized objects can assist cell membrane curvature, thus play an active role in their internalization; (3) to isolate the structures in which nanoparticles are internalized, in order to understand early sorting by cells, and further characterise the machinery for internalization; and finally (4) to define heterogeneity in cell response to nanoparticles in all of these aspects due to population context (i.e. cell cycle, local cell density) and identify eventual rare-cell behaviours. Several methods to ensure quantitative nanoparticle-cell interaction studies and discriminate cell subpopulations have already been developed in my previous work and now allow me to ask these questions. These methods will be combined with novel approaches applied for the first time in this arena, such as the use of full genome screens to study uptake; single molecule fluorescence methods to understand the role of nanoparticle curvature; novel cell fractionation methods coupled to quantitative proteomics to identify key proteins involved in uptake and early sorting; individual cell analysis to address heterogeneity in cell response to nanoparticles and study rare cells of interest. By disentangling the pathways involved in nanoparticle uptake and early sorting, the knowledge gained with NanoPaths will allow guiding the design of successful nanomedicines.

 Publications

year authors and title journal last update
List of publications.
2019 Valentina Francia, Catharina Reker-Smit, Guido Boel, Anna Salvati
Limits and challenges in using transport inhibitors to characterize how nano-sized drug carriers enter cells
published pages: 1533-1549, ISSN: 1743-5889, DOI: 10.2217/nnm-2018-0446
Nanomedicine 14/12 2020-03-20
2020 Roberta Bartucci, Christoffer Ã…berg, Barbro N. Melgert, Ykelien L. Boersma, Peter Olinga, Anna Salvati
Time‐Resolved Quantification of Nanoparticle Uptake, Distribution, and Impact in Precision‐Cut Liver Slices
published pages: 1906523, ISSN: 1613-6810, DOI: 10.1002/smll.201906523
Small 2020-03-20
2020 Keni Yang, Bárbara Mesquita, Peter Horvatovich, Anna Salvati
Tuning Liposome Composition to Modulate the Corona Forming in Human Serum and Uptake by Cells
published pages: , ISSN: 1742-7061, DOI: 10.1016/j.actbio.2020.02.018
Acta Biomaterialia 2020-03-20
2018 Valentina Francia, Aldy Aliyandi, Anna Salvati
Effect of the Development of a Cell Barrier on Nanoparticle Uptake in Endothelial Cells
published pages: , ISSN: 2040-3364, DOI: 10.1039/C8NR03171A
Nanoscale 2020-03-20

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The information about "NANOPATHS" are provided by the European Opendata Portal: CORDIS opendata.

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