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POLYBIOLUB SIGNED

Polymeric Analogs to Biolubrication Systems

Total Cost €

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EC-Contrib. €

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Partnership

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 POLYBIOLUB project word cloud

Explore the words cloud of the POLYBIOLUB project. It provides you a very rough idea of what is the project "POLYBIOLUB" about.

postmodification    lubrication    gels    mechanical    previously    combine    clinical    mechanisms    radical    environments    monitoring    functions    components    industrial    lubricious    gradients    host    resistant    polymeric    mimic    biomimetic    material    functionally    materials    tough    extraordinary    synergistically    radically    articular    synovial    joint    synthesis    composition    biolubrication    hip    play    glycoproteins    revealing    confined    environment    skills    structures    tool    wear    dependencies    polymerization    brush    gradient    yield    efforts    group    acid    structure    hyaluronic    hydrated    synthetic    charged    series    promise    appears    extensive    flow    followed    polymers    brushes    principal    biomolecules    fluid    revealed    lipids    either    polybiolub    yielding    act    cartilage    tribological    layered    stage    multiple    decade    appear    nature    multidimensional    characterization    joints    gel    natural    situ    grafting    fabricate    water    latest    accompanied    completely    structural    function    polymer   

Project "POLYBIOLUB" data sheet

The following table provides information about the project.

Coordinator
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH 

Organization address
address: Raemistrasse 101
city: ZUERICH
postcode: 8092
website: https://www.ethz.ch/de.html

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Project website http://www.surface.mat.ethz.ch/research/polymer-brushes/polymer-analogs-to-biolubrication-systems.html
 Total cost 2˙456˙570 €
 EC max contribution 2˙456˙570 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-ADG
 Funding Scheme ERC-ADG
 Starting year 2015
 Duration (year-month-day) from 2015-08-01   to  2020-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH CH (ZUERICH) coordinator 2˙456˙570.00

Map

 Project objective

Lubrication in nature is based on water, but only functions due to the presence of a host of biomolecules. In articular (e.g. hip) joints, it appears that the lubrication system is even more complex than previously believed, involving multiple gradients in structures and properties. Gels and brushes appear to play an important role in biolubrication, while highly confined, highly hydrated charged polymers are key to the important mechanical properties of cartilage. Components such as hyaluronic acid, glycoproteins, and lipids all appear to act synergistically to yield the extraordinary tribological properties of the cartilage-synovial-fluid system. POLYBIOLUB seeks to mimic the mechanisms revealed by the latest studies of cartilage, by means of the synthesis of functionally similar polymeric structures. This is a completely novel approach to the problem, which has the promise not only of revealing structural dependencies of cartilage function, but also of yielding radically new, biomimetic, lubricious, low-wear materials that could find applications in either industrial or clinical environments. The principal synthetic tool will be controlled radical polymerization in a flow environment, involving in situ growth monitoring, followed by a series of postmodification and grafting steps, to yield structures that are lubricious, wear resistant, and tough. These efforts will be accompanied by extensive characterization of composition, structure and mechanical/tribological properties at each stage.

Our group has extensive experience in controlled radical polymerization in a flow system, postmodification of polymers, brush-gel and layered polymer systems,. We also have over a decade of experience in water-based lubrication, natural lubrication, synovial-joint studies, and multidimensional gradient systems. The challenge now is to combine these skills to fabricate a completely new biomimetic material.

 Publications

year authors and title journal last update
List of publications.
2017 Edmondo M. Benetti, Chengjun Kang, Joydeb Mandal, Mohammad Divandari, Nicholas D. Spencer
Modulation of Surface-Initiated ATRP by Confinement: Mechanism and Applications
published pages: 5711-5718, ISSN: 0024-9297, DOI: 10.1021/acs.macromol.7b00919
Macromolecules 50/15 2019-07-04
2018 Mandal, Joydeb; id_orcid0000-0001-8905-8628; Varunprasaath, R.S.; Yan, Wenqing; Divandari, Mohammad; Spencer, Nicholas D.; Dubner, Matthias
In situ monitoring of SI-ATRP throughout multiple reinitiations under flow by means of a quartz crystal microbalance
published pages: 20048-20055, ISSN: 2046-2069, DOI: 10.3929/ethz-b-000271467
RSC Advances, 8 (36) 1 2019-07-04
2017 Chady Ghnatios, Christian H. Mathis, Rok Simic, Nicholas D. Spencer, Francisco Chinesta
Modeling soft, permeable matter with the proper generalized decomposition (PGD) approach, and verification by means of nanoindentation
published pages: 4482-4493, ISSN: 1744-683X, DOI: 10.1039/c7sm00246g
Soft Matter 13/25 2019-07-04
2018 Rok Simič, Christian H. Mathis, Nicholas D. Spencer
A two-step method for rate-dependent nano-indentation of hydrogels
published pages: 276-282, ISSN: 0032-3861, DOI: 10.1016/j.polymer.2018.01.017
Polymer 137 2019-07-04
2016 Isa, Lucio; Spencer, Nicholas D.; Mathis, Christian H.; Benetti, Edmondo M.; Simic, Rok; Divandari, Mohammad; Naik, Vikrant V.
ATR-IR Investigation of Solvent Interactions with Surface-Bound Polymers
published pages: 7588-7595, ISSN: 0743-7463, DOI: 10.1021/acs.langmuir.6b02086
Langmuir 32 2019-07-04

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