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LEGO SIGNED

Multimodal glycoconjugates: a molecular Lego approach for antitumoral immunotherapy

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 LEGO project word cloud

Explore the words cloud of the LEGO project. It provides you a very rough idea of what is the project "LEGO" about.

preliminary    structures    emerged    vitro    modules    immune    tumor    theranostic    efficient    utmost    ambition    recognition    ground    opportunity    chemical    therapeutic    sciences    labeling    selective    tumors    cancers    bloodstream    immunological    unresolved    endogenous    biochemistry    synthesize    glycoscience    complexity    intolerable    landmark    purpose    human    innovative    redirecting    cancer    beforehand    offers    functions    supramolecular    breakthroughs    paradigm    synthetic    questions    lego    diagnostic    biological    antibodies    engineering    effectors    alternative    treatments    treating    limited    biophysics    breaking    chemistry    patients    fundamental    immunotherapy    successful    combinations    immunochemistry    construct    tumoral    ideal    achievement    grant    horizons    smart    antibody    therapy    killing    despite    crossroad    interdisciplinary    controversial    molecules    medicinal    unprecedented    treatment    binding    biomolecular    pave    molecular    progress    combining    erc    immunization    modalities   

Project "LEGO" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE GRENOBLE ALPES 

There are not information about this coordinator. Please contact Fabio for more information, thanks.

 Coordinator Country France [FR]
 Total cost 2˙000˙000 €
 EC max contribution 2˙000˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-CoG
 Funding Scheme ERC-COG
 Starting year 2015
 Duration (year-month-day) from 2015-09-01   to  2020-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE GRENOBLE ALPES FR (GRENOBLE) coordinator 2˙000˙000.00
2    UNIVERSITE GRENOBLE ALPES FR (SAINT MARTIN D'HERES) coordinator 0.00
3    UNIVERSITE JOSEPH FOURIER GRENOBLE 1 FR (GRENOBLE) coordinator 0.00

Map

 Project objective

Despite significant progress in cancer therapy, current treatments are still controversial due to intolerable side effects. Targeted immunotherapy has recently emerged as an ideal alternative to improve treatment modalities for cancers patients. However, very limited approaches are available today and major issues remain to be addressed. The ERC grant offers a unique opportunity to propose a new paradigm for treating cancer. Through a ground-breaking interdisciplinary program, at the crossroad of supramolecular chemistry, synthetic chemistry, molecular engineering, biophysics, biochemistry, immunochemistry and glycoscience, it is my ambition to design, synthesize and study smart biomolecular structures with unprecedented combinations, complexity and immunological properties against cancers. To achieve this purpose, I will develop a “molecular LEGO” approach to construct synthetic molecules capable of redirecting endogenous antibodies present in the human bloodstream against tumors without preliminary immunization. Efficient tumoral killing by immune effectors will be provided by molecules combining innovative antibody and tumor binding modules that will be selected in vitro beforehand. To be successful, I will address fundamental questions that are still unresolved in chemical and biological sciences. The expected breakthroughs will represent a landmark achievement in these fields and will open promising horizons in cancer immunotherapy. Beyond this, it can be expected that our findings will pave the way to future development of synthetic molecules embedded with recognition, labeling, and/or therapeutic functions. They will thus find wider medicinal, diagnostic and even theranostic applications for which the development of more effective and selective biomolecular systems is of the utmost importance.

 Publications

year authors and title journal last update
List of publications.
2017 Carlo Pifferi, Nathalie Berthet, Olivier Renaudet
Cyclopeptide scaffolds in carbohydrate-based synthetic vaccines
published pages: 953-965, ISSN: 2047-4830, DOI: 10.1039/C7BM00072C
Biomater. Sci. 5/5 2020-04-23
2017 Carlo Pifferi, Baptiste Thomas, David Goyard, Nathalie Berthet, Olivier Renaudet
Heterovalent Glycodendrimers as Epitope Carriers for Antitumor Synthetic Vaccines
published pages: 16283-16296, ISSN: 0947-6539, DOI: 10.1002/chem.201702708
Chemistry - A European Journal 23/64 2020-04-23
2017 A Hoang, Eugénie Laigre, David Goyard, Eric Defrancq, Françoise Vinet, Pascal Dumy, Olivier Renaudet
Oxime-based glycocluster microarray
published pages: , ISSN: 1477-0520, DOI: 10.1039/C7OB00889A
Org. Biomol. Chem. 2020-04-23
2017 Carlo Pifferi, David Goyard, Emilie Gillon, Anne Imberty, Olivier Renaudet
Synthesis of Mannosylated Glycodendrimers and Evaluation against BC2L-A Lectin from Burkholderia Cenocepacia
published pages: 390-398, ISSN: 2192-6506, DOI: 10.1002/cplu.201600569
ChemPlusChem 82/3 2020-04-23
2016 Gour Chand Daskhan, Carlo Pifferi, Olivier Renaudet
Synthesis of a New Series of Sialylated Homo- and Heterovalent Glycoclusters by using Orthogonal Ligations
published pages: 477-484, ISSN: 2191-1363, DOI: 10.1002/open.201600062
ChemistryOpen 5/5 2020-04-23
2018 Eugénie Laigre, Claire Tiertant, David Goyard, Olivier Renaudet
Identification of Nanomolar Lectin Ligands by a Glycodendrimer Microarray
published pages: 14013-14020, ISSN: 2470-1343, DOI: 10.1021/acsomega.8b01526
ACS Omega 3/10 2020-04-23
2018 Eugénie Laigre, David Goyard, Claire Tiertant, Jérôme Dejeu, Olivier Renaudet
The study of multivalent carbohydrate–protein interactions by bio-layer interferometry
published pages: , ISSN: 1477-0520, DOI: 10.1039/C8OB01664J
Organic & Biomolecular Chemistry 2020-04-23
2018 João P. Ribeiro, Sarah Villringer, David Goyard, Liliane Coche-Guerente, Manuela Höferlin, Olivier Renaudet, Winfried Römer, Anne Imberty
Tailor-made Janus lectin with dual avidity assembles glycoconjugate multilayers and crosslinks protocells
published pages: , ISSN: 2041-6520, DOI: 10.1039/C8SC02730G
Chemical Science 2020-04-23

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The information about "LEGO" are provided by the European Opendata Portal: CORDIS opendata.

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