Explore the words cloud of the LEGO project. It provides you a very rough idea of what is the project "LEGO" about.
The following table provides information about the project.
UNIVERSITE GRENOBLE ALPES
There are not information about this coordinator. Please contact Fabio for more information, thanks.
|Coordinator Country||France [FR]|
|Total cost||2˙000˙000 €|
|EC max contribution||2˙000˙000 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2015-09-01 to 2020-08-31|
Take a look of project's partnership.
|1||UNIVERSITE GRENOBLE ALPES||FR (GRENOBLE)||coordinator||2˙000˙000.00|
|2||UNIVERSITE GRENOBLE ALPES||FR (SAINT MARTIN D'HERES)||coordinator||0.00|
|3||UNIVERSITE JOSEPH FOURIER GRENOBLE 1||FR (GRENOBLE)||coordinator||0.00|
Despite significant progress in cancer therapy, current treatments are still controversial due to intolerable side effects. Targeted immunotherapy has recently emerged as an ideal alternative to improve treatment modalities for cancers patients. However, very limited approaches are available today and major issues remain to be addressed. The ERC grant offers a unique opportunity to propose a new paradigm for treating cancer. Through a ground-breaking interdisciplinary program, at the crossroad of supramolecular chemistry, synthetic chemistry, molecular engineering, biophysics, biochemistry, immunochemistry and glycoscience, it is my ambition to design, synthesize and study smart biomolecular structures with unprecedented combinations, complexity and immunological properties against cancers. To achieve this purpose, I will develop a “molecular LEGO” approach to construct synthetic molecules capable of redirecting endogenous antibodies present in the human bloodstream against tumors without preliminary immunization. Efficient tumoral killing by immune effectors will be provided by molecules combining innovative antibody and tumor binding modules that will be selected in vitro beforehand. To be successful, I will address fundamental questions that are still unresolved in chemical and biological sciences. The expected breakthroughs will represent a landmark achievement in these fields and will open promising horizons in cancer immunotherapy. Beyond this, it can be expected that our findings will pave the way to future development of synthetic molecules embedded with recognition, labeling, and/or therapeutic functions. They will thus find wider medicinal, diagnostic and even theranostic applications for which the development of more effective and selective biomolecular systems is of the utmost importance.
|year||authors and title||journal||last update|
Carlo Pifferi, Nathalie Berthet, Olivier Renaudet
Cyclopeptide scaffolds in carbohydrate-based synthetic vaccines
published pages: 953-965, ISSN: 2047-4830, DOI: 10.1039/C7BM00072C
|Biomater. Sci. 5/5||2020-04-23|
Carlo Pifferi, Baptiste Thomas, David Goyard, Nathalie Berthet, Olivier Renaudet
Heterovalent Glycodendrimers as Epitope Carriers for Antitumor Synthetic Vaccines
published pages: 16283-16296, ISSN: 0947-6539, DOI: 10.1002/chem.201702708
|Chemistry - A European Journal 23/64||2020-04-23|
A Hoang, EugÃ©nie Laigre, David Goyard, Eric Defrancq, FranÃ§oise Vinet, Pascal Dumy, Olivier Renaudet
Oxime-based glycocluster microarray
published pages: , ISSN: 1477-0520, DOI: 10.1039/C7OB00889A
|Org. Biomol. Chem.||2020-04-23|
Carlo Pifferi, David Goyard, Emilie Gillon, Anne Imberty, Olivier Renaudet
Synthesis of Mannosylated Glycodendrimers and Evaluation against BC2L-A Lectin from Burkholderia Cenocepacia
published pages: 390-398, ISSN: 2192-6506, DOI: 10.1002/cplu.201600569
Gour Chand Daskhan, Carlo Pifferi, Olivier Renaudet
Synthesis of a New Series of Sialylated Homo- and Heterovalent Glycoclusters by using Orthogonal Ligations
published pages: 477-484, ISSN: 2191-1363, DOI: 10.1002/open.201600062
EugÃ©nie Laigre, Claire Tiertant, David Goyard, Olivier Renaudet
Identification of Nanomolar Lectin Ligands by a Glycodendrimer Microarray
published pages: 14013-14020, ISSN: 2470-1343, DOI: 10.1021/acsomega.8b01526
|ACS Omega 3/10||2020-04-23|
EugÃ©nie Laigre, David Goyard, Claire Tiertant, JÃ©rÃ´me Dejeu, Olivier Renaudet
The study of multivalent carbohydrateâ€“protein interactions by bio-layer interferometry
published pages: , ISSN: 1477-0520, DOI: 10.1039/C8OB01664J
|Organic & Biomolecular Chemistry||2020-04-23|
JoÃ£o P. Ribeiro, Sarah Villringer, David Goyard, Liliane Coche-Guerente, Manuela HÃ¶ferlin, Olivier Renaudet, Winfried RÃ¶mer, Anne Imberty
Tailor-made Janus lectin with dual avidity assembles glycoconjugate multilayers and crosslinks protocells
published pages: , ISSN: 2041-6520, DOI: 10.1039/C8SC02730G
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The information about "LEGO" are provided by the European Opendata Portal: CORDIS opendata.
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