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miRNA in Immunity TERMINATED
Testing the role of miRNA-mediated non-cell autonomous gene regulation in type-2 immunity
Total Cost €
0EC-Contrib. €
0Partnership
0Views
0miRNA in Immunity project word cloud
Explore the words cloud of the miRNA in Immunity project. It provides you a very rough idea of what is the project "miRNA in Immunity" about.
transfer
delivered
contact
dicer
associate
silencing
dependent
active
micrornas
plants
argonaut
autonomous
ago
independent
deficient
worms
observations
allergy
mechanisms
distinctive
found
populations
protein
suppressing
exported
intercellular
2fl
treg
transport
th1
cell
regulate
released
mirna
dimension
mirnas
treat
release
translate
extracellular
incentivise
helminth
communication
extrinsic
vesicles
mice
immunity
th2
mammalian
anti
disease
mediated
proteins
intervention
fl
representing
exogenous
expression
intrinsic
rna
catalytically
inflammatory
gene
transferred
express
cells
packaged
differentiation
regulation
contributes
diseases
therapeutic
Project "miRNA in Immunity" data sheet
The following table provides information about the project.
| Coordinator |
THE FRANCIS CRICK INSTITUTE LIMITED
Organization address contact info |
| Coordinator Country | United Kingdom [UK] |
| Total cost | 1˙762˙510 € |
| EC max contribution | 1˙762˙510 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2014-CoG |
| Funding Scheme | ERC-COG |
| Starting year | 2015 |
| Duration (year-month-day) | from 2015-08-01 to 2020-07-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | THE FRANCIS CRICK INSTITUTE LIMITED | UK (LONDON) | coordinator | 1˙762˙510.00 |
Map
Project objective
MicroRNAs (miRNAs) can be transferred between cells, representing an exciting new dimension to intercellular communication, referred to as non-cell-autonomous gene regulation. We recently identified that distinct miRNAs are packaged and exported from TREG cells and delivered directly to TH1 cells, suppressing T cell-mediated disease. Different T cell populations express different miRNAs and release a distinctive set of extracellular miRNAs. In this proposal we will identify whether the transfer of miRNAs between cells contributes to T cell development, T cell differentiation and TH2-mediated allergy and anti-helminth immunity. miRNA-mediated gene silencing requires one of four catalytically active Argonaut (Ago) proteins to regulate gene expression. To investigate miRNA transport between cells, we have generated novel mice with miRNA-deficient T cells that can (Dicer–/–) or cannot (Dicer–/–Ago-1,-3,-4–/– Ago-2fl/fl) respond to exogenous miRNAs. Using these novel mice we will identify which Ago protein(s) specific miRNAs associate with and which Ago proteins are required for miRNA-mediated gene regulation in T cells. TH2 cells express unique miRNAs, which can be found within TH2 cells and in extracellular vesicles released from TH2 cells. We have generated several new TH2-associated miRNA-deficient mice to investigate the cell intrinsic (cell-autonomous) and extrinsic (non-cell-autonomous) role of these miRNAs in TH2-mediated allergy and anti-helminth immunity. Studies in plants and worms have identified various mechanisms of RNA transfer between cells, involving cell-contact dependent and independent mechanisms. We will translate these observations into mammalian systems and identify the mechanisms of miRNA transfer. Results from this work will identify novel miRNA-mediated pathways and incentivise state-of-the-art approaches for novel therapeutic intervention to treat inflammatory diseases.
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The information about "MIRNA IN IMMUNITY" are provided by the European Opendata Portal: CORDIS opendata.
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lastchecktime (2024-10-10 21:21:35) correctly updated