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ArtOxiZymes

Artificial Oxidation Enzymes for Highly Selective Waste Free Hydroxylation of Alkanes

Total Cost €

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EC-Contrib. €

0

Partnership

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 ArtOxiZymes project word cloud

Explore the words cloud of the ArtOxiZymes project. It provides you a very rough idea of what is the project "ArtOxiZymes" about.

natural    peroxide    c10    alkanes    bonds    detergents    substrate    hydrogen    competence    bind    orientation    abundant    selective    chemocatalysts    chemicals    sustainable    plasticisers    feedstocks    blocks    gain    valuable    oxidation    recognition    lends    nature    society    substrates    consumption    economy    oxygen    bound    waste    reductions    ol    mild    octan    mobility    leads    green    direct    artificial    hydroxylation    researcher    position    one    unfavourable    relying    economical    reaction    selectively    prefunctionalized    forming    interdisciplinary    catalysts    functionalization    industries    creative    form    collaborations       octane    metalloenzymes    diversify    pockets    generates    building    oxidants    synthesis    efficient    contribution    itself    sure    c1    molecular    combining    catalysis    tremendous    energy    contrast    maximise    c8    alcohols    biocatalysis    linear    innovative    chemical    unsolved    protein    homogenous    correct    utilise    give    materials   

Project "ArtOxiZymes" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS 

Organization address
address: NORTH STREET 66 COLLEGE GATE
city: ST ANDREWS
postcode: KY16 9AJ
website: www.st-andrews.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://amandajarvis.org
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-10-01   to  2017-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS UK (ST ANDREWS) coordinator 183˙454.00

Map

 Project objective

One of the major challenges facing the chemical industries is the sustainable production of chemicals from natural resources. The challenge includes making sure that chemical processes are as ‘green’ and economical as possible, and that sustainable and abundant resources are used where possible. One type of reaction that lends itself to sustainable processes is the direct functionalization of C-H to C-X (X = O, N, C) bonds, as it generates far less chemical waste and leads to tremendous reduction of energy use than methods relying on prefunctionalized materials. The objective of this project is to achieve the C1-selective hydroxylation of n-alkanes to give n-alcohols e.g. octane to octan-1-ol, using mild reaction conditions and green oxidants such as oxygen or hydrogen peroxide, which is currently an unsolved problem. Linear alcohols are of interest as they form some of the major building blocks used in the chemical industries, for example C8-C10 alcohols for the synthesis of plasticisers and detergents. We will achieve this aim by combining traditional homogenous catalysis and biocatalysis for the development of artificial metalloenzymes as catalysts, which utilise the molecular recognition concepts of nature to bind substrates selectively in protein pockets. The target substrate will thus be bound in the correct orientation enabling selective oxidation at the target position, in contrast to traditional chemocatalysts which give a highly unfavourable product distribution. This will lead to more efficient use of valuable feedstocks and large reductions in chemical waste production and energy consumption, compared to the traditional methods for forming C1-alcohols, all contributing to a green and sustainable society. The researcher will diversify her competence, build new collaborations and gain interdisciplinary mobility through this creative and highly innovative project allowing her to maximise her contribution to the knowledge-based economy and society.

 Publications

year authors and title journal last update
List of publications.
2017 Amanda G. Jarvis, Lorenz Obrecht, Peter J. Deuss, Wouter Laan, Emma K. Gibson, Peter P. Wells, Paul C. J. Kamer
Enzyme Activity by Design: An Artificial Rhodium Hydroformylase for Linear Aldehydes
published pages: 13596-13600, ISSN: 1433-7851, DOI: 10.1002/anie.201705753
Angewandte Chemie International Edition 56/44 2019-06-13

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