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ArtOxiZymes

Artificial Oxidation Enzymes for Highly Selective Waste Free Hydroxylation of Alkanes

Total Cost €

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EC-Contrib. €

0

Partnership

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 ArtOxiZymes project word cloud

Explore the words cloud of the ArtOxiZymes project. It provides you a very rough idea of what is the project "ArtOxiZymes" about.

c10    competence    maximise    substrate    bound    economical    orientation    building    diversify    ol    nature    oxidants    relying    unsolved    feedstocks    green    synthesis    functionalization    interdisciplinary    metalloenzymes    reaction    forming    alcohols    protein    catalysis    waste    hydrogen    abundant    mobility    economy    itself    give    hydroxylation    plasticisers    efficient    mild    c8    catalysts    form    substrates    tremendous    recognition    homogenous    contribution    lends    consumption    oxygen    sustainable    detergents    contrast    oxidation    gain    chemocatalysts    sure    position    peroxide    leads    molecular    prefunctionalized    reductions    direct    researcher    collaborations    selective    energy    unfavourable    biocatalysis    artificial    chemical    generates    innovative    bind    linear       chemicals    c1    alkanes    correct    bonds    industries    society    natural    materials    utilise    octan    pockets    valuable    octane    one    creative    combining    selectively    blocks   

Project "ArtOxiZymes" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS 

Organization address
address: NORTH STREET 66 COLLEGE GATE
city: ST ANDREWS
postcode: KY16 9AJ
website: www.st-andrews.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://amandajarvis.org
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-10-01   to  2017-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS UK (ST ANDREWS) coordinator 183˙454.00

Map

 Project objective

One of the major challenges facing the chemical industries is the sustainable production of chemicals from natural resources. The challenge includes making sure that chemical processes are as ‘green’ and economical as possible, and that sustainable and abundant resources are used where possible. One type of reaction that lends itself to sustainable processes is the direct functionalization of C-H to C-X (X = O, N, C) bonds, as it generates far less chemical waste and leads to tremendous reduction of energy use than methods relying on prefunctionalized materials. The objective of this project is to achieve the C1-selective hydroxylation of n-alkanes to give n-alcohols e.g. octane to octan-1-ol, using mild reaction conditions and green oxidants such as oxygen or hydrogen peroxide, which is currently an unsolved problem. Linear alcohols are of interest as they form some of the major building blocks used in the chemical industries, for example C8-C10 alcohols for the synthesis of plasticisers and detergents. We will achieve this aim by combining traditional homogenous catalysis and biocatalysis for the development of artificial metalloenzymes as catalysts, which utilise the molecular recognition concepts of nature to bind substrates selectively in protein pockets. The target substrate will thus be bound in the correct orientation enabling selective oxidation at the target position, in contrast to traditional chemocatalysts which give a highly unfavourable product distribution. This will lead to more efficient use of valuable feedstocks and large reductions in chemical waste production and energy consumption, compared to the traditional methods for forming C1-alcohols, all contributing to a green and sustainable society. The researcher will diversify her competence, build new collaborations and gain interdisciplinary mobility through this creative and highly innovative project allowing her to maximise her contribution to the knowledge-based economy and society.

 Publications

year authors and title journal last update
List of publications.
2017 Amanda G. Jarvis, Lorenz Obrecht, Peter J. Deuss, Wouter Laan, Emma K. Gibson, Peter P. Wells, Paul C. J. Kamer
Enzyme Activity by Design: An Artificial Rhodium Hydroformylase for Linear Aldehydes
published pages: 13596-13600, ISSN: 1433-7851, DOI: 10.1002/anie.201705753
Angewandte Chemie International Edition 56/44 2019-06-13

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