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MASSTRPLAN SIGNED

MASS Spectrometry TRaining network for Protein Lipid adduct ANalysis

Total Cost €

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EC-Contrib. €

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Partnership

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 MASSTRPLAN project word cloud

Explore the words cloud of the MASSTRPLAN project. It provides you a very rough idea of what is the project "MASSTRPLAN" about.

biomolecule    molecular    biotech    scientists    inflammation    bioinformatics    economy    theoretical    entrepreneurial    therapies    functional    complementary    lost    15    phospholipids    translational    protocols    mortality    mechanisms    cell    relevance    responsible    bioinformatic    stage    give    broad    billion    cohort    roles    heterogeneous    industrial    train    materials    cross    extensive    network    skills    inflammatory    generation    cancer    perspective    commercializable    proteins    chronic    clinical    cvd    technological    chromatography    time    interdisciplinary    contribution    disease    47    causes    oxidative    modifications    samples    196    skill    engage    biotechnology    biological    urgently    training    diseases    detect    secondments    oxidized    deaths    assessing    analytical    pathophysiology    etn    masstrplan    beneficiaries    diabetes    biochemical    trained    alone    leaders    detecting    disorders    spectrometry    mass    healthcare    dysfunction    diagnostic    microscopy    cardiovascular    mobility    yield    techniques    esrs    dearly    translate    academic    multidisciplinary    tools   

Project "MASSTRPLAN" data sheet

The following table provides information about the project.

Coordinator
ASTON UNIVERSITY 

Organization address
address: ASTON TRIANGLE
city: BIRMINGHAM
postcode: B4 7ET
website: www.aston.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://www.masstrplan.org
 Total cost 3˙545˙010 €
 EC max contribution 3˙545˙010 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2015
 Funding Scheme MSCA-ITN-ETN
 Starting year 2015
 Duration (year-month-day) from 2015-10-01   to  2019-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ASTON UNIVERSITY UK (BIRMINGHAM) coordinator 546˙575.00
2    UNIVERSITAET LEIPZIG DE (LEIPZIG) participant 498˙432.00
3    AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS ES (MADRID) participant 495˙745.00
4    UNIVERSIDADE DE AVEIRO PT (AVEIRO) participant 476˙712.00
5    MOLOGIC LTD UK (BEDFORD) participant 273˙287.00
6    CENTRO CARDIOLOGICO MONZINO IT (MILANO) participant 258˙061.00
7    UNIVERSITA DEGLI STUDI DI MILANO IT (MILANO) participant 258˙061.00
8    VIB VZW BE (ZWIJNAARDE - GENT) participant 250˙560.00
9    THERMO FISHER SCIENTIFIC (BREMEN) GMBH DE (BREMEN) participant 249˙216.00
10    CENTRO HOSPITALAR E UNIVERSITARIO DE COIMBRA E.P.E. PT (COIMBRA) participant 238˙356.00
11    INSTITUTO PORTUGUES DO SANGUE E DA TRANSPLANTACAO IP PT (LISBOA) participant 0.00
12    AB SCIEX UK LIMITED UK (WARRINGTON) partner 0.00
13    Achucarro Basque Center for Neurosc ES (Leioa) partner 0.00
14    Antec Leyden BV NL (Zoeterwoude) partner 0.00
15    Cayman Chemical Company UM (Ann Arbor) partner 0.00
16    CELL2B ADVANCED THERAPEUTICS SA PT (CANTANHEDE) partner 0.00
17    Centro Hospitalar Baixo Vouga PT (Aveiro) partner 0.00
18    DSM FOOD SPECIALTIES BV NL (DELFT) partner 0.00
19    DSM Nutritional Products Ltd CH (Kaiseraugst) partner 0.00
20    ELSEVIER BV NL (AMSTERDAM) partner 0.00
21    European Proteomics Association DE (Potsdam) partner 0.00
22    Red Española de Microscopía Óptica ES (Madrid) partner 0.00
23    Society for Free Radical Research Europe UK (London) partner 0.00
24    UNICAM SISTEMAS ANALITICOS PT (Algés) partner 0.00
25    Universitatsklinikum Leipzig DE (Leipzig) partner 0.00
26    Waters Corp (Micromass UK ltd) UK (Wilmslow) partner 0.00

Map

 Project objective

MASSTRPLAN will train the next generation of interdisciplinary research leaders in advanced molecular analytical techniques to detect oxidized phospholipids & proteins in biological & clinical samples, evaluate their biochemical roles in inflammation, and translate these findings to develop new diagnostic tools. Chronic inflammatory diseases such as diabetes, cardiovascular disease (CVD) & cancer are major causes of mortality and cost the EU economy dearly in healthcare and lost working time; CVD alone is estimated to be responsible for 47% of deaths and to cost the EU €196 billion a year. Scientists able to develop advanced analytical tools for detecting oxidative biomolecule modifications and assessing their contribution to cell dysfunction & disease are urgently needed. The objectives of MASSTRPLAN are to 1) train early stage researchers (ESRs) in advanced and novel chromatography, mass spectrometry, and complementary techniques including microscopy and bioinformatics to detect challenging heterogeneous biomolecule modifications and determine their functional effects; 2) give ESRs a broad perspective on relevance & mechanisms of oxidative modifications in pathophysiology and biotechnology; 3) enable ESRs trained in technology development to engage effectively with the clinical sector; and 4) train ESRs in translational and development skills to produce new protocols, materials and commercializable diagnostic tools. The ETN will achieve this by bringing together 10 beneficiaries and 15 partners from academic, industrial and healthcare organizations working in analytical, bioinformatic, biological, clinical & biotech fields to provide multidisciplinary, cross-sector training. Extensive mobility, industrial secondments and network-wide training will yield a cohort of analytical scientists with the unique theoretical, technological, and entrepreneurial skill set to yield new understanding of oxidative inflammatory disorders, leading to better tools and therapies.

 Deliverables

List of deliverables.
Joint Public Engagement Event Other 2020-03-13 11:18:19
Special Issue on Lipoxidation Targets Documents, reports 2020-03-13 11:18:27
Annual Management Reports Documents, reports 2020-03-13 11:18:21
Network Summer School 2 Other 2020-03-13 11:18:20
Database of (lip)oxPTM Fragmentation Other 2020-03-13 11:18:27
Special Issue on Novel MS Methodology Documents, reports 2020-03-13 11:18:27
Bioinformatics Tool for oxPLs Demonstrators, pilots, prototypes 2020-03-13 11:18:26
Joint Training Certificates Awarded Documents, reports 2020-03-13 11:18:20
All ESR projects completed and reports submitted Documents, reports 2020-03-13 11:18:26
1st publication All ESRs Documents, reports 2020-03-13 11:18:25
Database of (lip)oxidation targets Other 2020-03-13 11:18:27
Final Technical Training Reports Documents, reports 2020-03-13 11:18:26
Open Conference Other 2020-03-13 11:18:24
Protocols for novel chemical labeling Demonstrators, pilots, prototypes 2020-03-13 11:18:25
Set of LC-MS Protocols for ox biomols Demonstrators, pilots, prototypes 2020-03-13 11:18:27
Technical Training Reports Documents, reports 2019-07-09 19:55:41
Project Website Websites, patent fillings, videos etc. 2019-07-09 19:55:40
Bioinformatics Tool for oxPTMs Demonstrators, pilots, prototypes 2019-07-09 19:55:41
Network Summer School 1 Other 2019-07-09 19:55:41
Mutant Protein Constructs Other 2019-07-09 19:55:41
Data Management Plan Agreed Documents, reports 2019-07-09 19:55:40
ESR Recruitment Other 2019-07-09 19:55:41
Database of oxPL/NO2PL Fragmentation Other 2019-07-09 19:55:41

Take a look to the deliverables list in detail:  detailed list of MASSTRPLAN deliverables.

 Publications

year authors and title journal last update
List of publications.
2018 M. Rosário Domingues, Ana Campos, Simone Colombo, Tânia Melo, Pedro Domingues
Radical induced oxidation of di-oleoyl phosphatidylserine using mass spectrometry revealed preferential oxydation of Sn-2 oleoyl chain
published pages: S118, ISSN: 0891-5849, DOI: 10.1016/j.freeradbiomed.2018.04.390
Free Radical Biology and Medicine 120 2019-12-16
2018 Javier-Fernando Montero-Bullón, Tânia Melo, M Rosário M Domingues, Pedro Domingues
Study of covalent adduction of nitrated phospholipids to peptides using tandem mass spectrometry in different instruments
published pages: S121, ISSN: 0891-5849, DOI: 10.1016/j.freeradbiomed.2018.04.399
Free Radical Biology and Medicine 120 2019-12-16
2019 Elisabete Maciel, Bruno M. Neves, João Martins, Simone Colombo, Maria Teresa Cruz, Pedro Domingues, M. Rosário M. Domingues
Oxidized phosphatidylserine mitigates LPS-triggered macrophage inflammatory status through modulation of JNK and NF-kB signaling cascades
published pages: 30-38, ISSN: 0898-6568, DOI: 10.1016/j.cellsig.2019.04.015
Cellular Signalling 61 2019-12-16
2019 Gabriele Cruciani, Pedro Domingues, Maria Fedorova, Francesco Galli, Corinne M. Spickett
Redox lipidomics and adductomics - Advanced analytical strategies to study oxidized lipids and lipid-protein adducts
published pages: 1-5, ISSN: 0891-5849, DOI: 10.1016/j.freeradbiomed.2019.07.027
Free Radical Biology and Medicine 144 2019-12-16
2019 Mike Lange, Zhixu Ni, Angela Criscuolo, Maria Fedorova
Liquid Chromatography Techniques in Lipidomics Research
published pages: 77-100, ISSN: 0009-5893, DOI: 10.1007/s10337-018-3656-4
Chromatographia 82/1 2019-12-16
2019 Florian Füssl, Angela Criscuolo, Ken Cook, Kai Scheffler, Jonathan Bones
Cracking Proteoform Complexity of Ovalbumin with Anion-Exchange Chromatography–High-Resolution Mass Spectrometry under Native Conditions
published pages: 3689-3702, ISSN: 1535-3893, DOI: 10.1021/acs.jproteome.9b00375
Journal of Proteome Research 18/10 2019-11-26
2019 Isabel Campos-Pinto, Lucía Méndez, James Schouten, John Wilkins, Maria Fedorova, Andrew R. Pitt, Paul Davis, Corinne M. Spickett
Epitope mapping and characterization of 4-hydroxy-2-nonenal modified-human serum albumin using two different polyclonal antibodies
published pages: 234-244, ISSN: 0891-5849, DOI: 10.1016/j.freeradbiomed.2019.05.008
Free Radical Biology and Medicine 144 2019-11-26
2019 Zhixu Ni, Bebiana C. Sousa, Simone Colombo, Catarina B. Afonso, Tania Melo, Andrew R. Pitt, Corinne M. Spickett, Pedro Domingues, M. Rosário Domingues, Maria Fedorova, Angela Criscuolo
Evaluation of air oxidized PAPC: A multi laboratory study by LC-MS/MS
published pages: 156-166, ISSN: 0891-5849, DOI: 10.1016/j.freeradbiomed.2019.06.013
Free Radical Biology and Medicine 144 2019-11-26
2018 Javier-Fernando Montero-Bullon, Tânia Melo, Maria Rosário Domingues, Pedro Domingues
Characterization of Nitrophospholipid-Peptide Covalent Adducts by Electrospray Tandem Mass Spectrometry: A First Screening Analysis Using Different Instrumental Platforms
published pages: 1800101, ISSN: 1438-7697, DOI: 10.1002/ejlt.201800101
European Journal of Lipid Science and Technology 120/12 2019-11-26
2019 Zhixu Ni, Laura Goracci, Gabriele Cruciani, Maria Fedorova
Computational solutions in redox lipidomics – Current strategies and future perspectives
published pages: 110-123, ISSN: 0891-5849, DOI: 10.1016/j.freeradbiomed.2019.04.027
Free Radical Biology and Medicine 144 2019-11-26
2019 Dolores Pérez-Sala, Rosário Domingues
Lipoxidation targets: From basic mechanisms to pathophysiology
published pages: 101208, ISSN: 2213-2317, DOI: 10.1016/j.redox.2019.101208
Redox Biology 23 2019-11-26
2017 Javier Egea, Isabel Fabregat, Yves M. Frapart, Pietro Ghezzi, Agnes Görlach, Thomas Kietzmann, Kateryna Kubaichuk, Ulla G. Knaus, Manuela G. Lopez, Gloria Olaso-Gonzalez, Andreas Petry, Rainer Schulz, Jose Vina, Paul Winyard, Kahina Abbas, Opeyemi S. Ademowo, Catarina B. Afonso, Ioanna Andreadou, Haike Antelmann, Fernando Antunes, Mutay Aslan, Markus M. Bachschmid, Rui M. Barbosa, Vsevolod Belous
European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)
published pages: 94-162, ISSN: 2213-2317, DOI: 10.1016/j.redox.2017.05.007
Redox Biology 13 2019-11-26
2019 Javier-Fernando Montero-Bullon, Tânia Melo, Rita Ferreira, Ana Isabel Padrão, Paula A. Oliveira, M. Rosário M. Domingues, Pedro Domingues
Exercise training counteracts urothelial carcinoma-induced alterations in skeletal muscle mitochondria phospholipidome in an animal model
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-49010-6
Scientific Reports 9/1 2019-11-26
2019 Sofia Duarte, Tânia Melo, Rosário Domingues, Juan de Dios Alché, Dolores Pérez-Sala
Insight into the cellular effects of nitrated phospholipids: Evidence for pleiotropic mechanisms of action
published pages: 192-202, ISSN: 0891-5849, DOI: 10.1016/j.freeradbiomed.2019.06.003
Free Radical Biology and Medicine 144 2019-11-26
2019 Bebiana C. Sousa, Tanzim Ahmed, William L. Dann, Jed Ashman, Alexandre Guy, Thierry Durand, Andrew R. Pitt, Corinne M. Spickett
Short-chain lipid peroxidation products form covalent adducts with pyruvate kinase and inhibit its activity in vitro and in breast cancer cells
published pages: 223-233, ISSN: 0891-5849, DOI: 10.1016/j.freeradbiomed.2019.05.028
Free Radical Biology and Medicine 144 2019-11-26
2018 Andreia Mónico, Sofia Duarte, Maria A. Pajares, Dolores Pérez-Sala
Effects of oxidants and electrophiles on vimentin assembly
published pages: S69, ISSN: 0891-5849, DOI: 10.1016/j.freeradbiomed.2018.04.227
Free Radical Biology and Medicine 120 2019-11-26
2019 Tânia Melo, Javier-Fernando Montero-Bullón, Pedro Domingues, M. Rosário Domingues
Discovery of bioactive nitrated lipids and nitro-lipid-protein adducts using mass spectrometry-based approaches
published pages: 101106, ISSN: 2213-2317, DOI: 10.1016/j.redox.2019.101106
Redox Biology 23 2019-11-26
2019 Leanne C. Nye, Jonathan P. Williams, Nyasha C. Munjoma, Marine P.M. Letertre, Muireann Coen, Robbin Bouwmeester, Lennart Martens, Jonathan R. Swann, Jeremy K. Nicholson, Robert S. Plumb, Michael McCullagh, Lee A. Gethings, Steven Lai, James I. Langridge, Johannes P.C. Vissers, Ian D. Wilson
A comparison of collision cross section values obtained via travelling wave ion mobility-mass spectrometry and ultra high performance liquid chromatography-ion mobility-mass spectrometry: Application to the characterisation of metabolites in rat urine
published pages: 386-396, ISSN: 0021-9673, DOI: 10.1016/j.chroma.2019.06.056
Journal of Chromatography A 1602 2019-11-11
2019 Ana S C Silva, Robbin Bouwmeester, Lennart Martens, Sven Degroeve
Accurate peptide fragmentation predictions allow data driven approaches to replace and improve upon proteomics search engine scoring functions
published pages: , ISSN: 1367-4803, DOI: 10.1093/bioinformatics/btz383
Bioinformatics 2019-11-11
2019 Sofia Duarte, Álvaro Viedma-Poyatos, Elena Navarro-Carrasco, Alma E. Martínez, María A. Pajares, Dolores Pérez-Sala
Vimentin filaments interact with the actin cortex in mitosis allowing normal cell division
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-12029-4
Nature Communications 10/1 2019-10-29
2019 Dolores Pérez-Sala, Rosário Domingues
Lipoxidation targets: From basic mechanisms to pathophysiology
published pages: 101208, ISSN: 2213-2317, DOI: 10.1016/j.redox.2019.101208
Redox Biology 2019-10-29
2019 Alma Martinez Fernandez, Luca Regazzoni, Maura Brioschi, Erica Gianazza, Piergiuseppe Agostoni, Giancarlo Aldini, Cristina Banfi
Pro-oxidant and pro-inflammatory effects of glycated albumin on cardiomyocytes
published pages: , ISSN: 0891-5849, DOI: 10.1016/j.freeradbiomed.2019.06.023
Free Radical Biology and Medicine 2019-10-03
2018 Marco Mol, Genny Degani, Crescenzo Coppa, Giovanna Baron, Laura Popolo, Marina Carini, Giancarlo Aldini, Giulio Vistoli, Alessandra Altomare
Advanced lipoxidation end products (ALEs) as RAGE binders: Mass spectrometric and computational studies to explain the reasons why
published pages: 101083, ISSN: 2213-2317, DOI: 10.1016/j.redox.2018.101083
Redox Biology 2019-10-03
2017 Bebiana C. Sousa, Andrew R. Pitt, Corinne M. Spickett
Chemistry and analysis of HNE and other prominent carbonyl-containing lipid oxidation compounds
published pages: 294-308, ISSN: 0891-5849, DOI: 10.1016/j.freeradbiomed.2017.02.003
Free Radical Biology and Medicine 111 2019-07-09
2018 Álvaro Viedma-Poyatos, Yolanda de Pablo, Milos Pekny, Dolores Pérez-Sala
The cysteine residue of glial fibrillary acidic protein is a critical target for lipoxidation and required for efficient network organization
published pages: 380-394, ISSN: 0891-5849, DOI: 10.1016/j.freeradbiomed.2018.04.007
Free Radical Biology and Medicine 120 2019-07-09
2018 Simone Colombo, Carmen Martín-Sierra, Tânia Melo, Paula Laranjeira, Artur Paiva, Pedro Domingues, M. Rosário Domingues
Modulation of the inflammatory response of immune cells in human peripheral blood by oxidized arachidonoyl aminophospholipids
published pages: 64-71, ISSN: 0003-9861, DOI: 10.1016/j.abb.2018.10.003
Archives of Biochemistry and Biophysics 660 2019-08-05
2019 Andreia Mónico, Sofia Duarte, María A. Pajares, Dolores Pérez-Sala
Vimentin disruption by lipoxidation and electrophiles: Role of the cysteine residue and filament dynamics
published pages: 101098, ISSN: 2213-2317, DOI: 10.1016/j.redox.2019.101098
Redox Biology 2019-08-05
2019 Carmen Martín-Sierra, Ricardo Martins, Paula Laranjeira, A. Margarida Abrantes, R. Caetano Oliveira, J. Guilherme Tralhão, M. Filomena Botelho, Emanuel Furtado, Rosário Domingues, Artur Paiva
Functional Impairment of Circulating FcεRI + Monocytes and Myeloid Dendritic Cells in Hepatocellular Carcinoma and Cholangiocarcinoma Patients
published pages: , ISSN: 1552-4949, DOI: 10.1002/cyto.b.21777
Cytometry Part B: Clinical Cytometry 2019-08-05
2019 Silvia Zorrilla, Andreia Mónico, Sofia Duarte, Germán Rivas, Dolores Pérez-Sala, María A. Pajares
Integrated approaches to unravel the impact of protein lipoxidation on macromolecular interactions
published pages: , ISSN: 0891-5849, DOI: 10.1016/j.freeradbiomed.2019.04.011
Free Radical Biology and Medicine 2019-08-05
2019 Giulia Coliva, Sofia Duarte, Dolores Pérez-Sala, Maria Fedorova
Impact of inhibition of the autophagy-lysosomal pathway on biomolecules carbonylation and proteome regulation in rat cardiac cells
published pages: 101123, ISSN: 2213-2317, DOI: 10.1016/j.redox.2019.101123
Redox Biology 2019-08-05
2018 Julita Pietrzak, Corinne M. Spickett, Tomasz Płoszaj, László Virág, Agnieszka Robaszkiewicz
PARP1 promoter links cell cycle progression with adaptation to oxidative environment
published pages: 1-5, ISSN: 2213-2317, DOI: 10.1016/j.redox.2018.05.017
Redox Biology 18 2019-07-09
2018 Simone Colombo, Tânia Melo, Marta Martínez-López, M. Jesús Carrasco, M. Rosário Domingues, Dolores Pérez-Sala, Pedro Domingues
Phospholipidome of endothelial cells shows a different adaptation response upon oxidative, glycative and lipoxidative stress
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-30695-0
Scientific Reports 8/1 2019-07-09

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