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DeFiNER SIGNED

Nucleotide Excision Repair: Decoding its Functional Role in Mammals

Total Cost €

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EC-Contrib. €

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Partnership

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 DeFiNER project word cloud

Explore the words cloud of the DeFiNER project. It provides you a very rough idea of what is the project "DeFiNER" about.

solid    play    mammalian    disorders    mammals    connected    developmental    regulation    protein    aging    vivo    linked    regard    dimensional    give    transcription    transgenic    reprogramming    expression    ner    itself    dissecting    tightly    remodelling    defects    defect    heterogeneity    poorly    besides    primarily    repair    reveals    genome    vastly    operate    random    maintenance    disease    diverse    organization    functional    dna    excision    varying    contributions    cells    organism    functionally    mechanisms    biological    paramount    faithfully    hormones    proteins    execute    nucleotide    explained    mice    gene    progeroid    unexplored    progeny    cancer    pluripotent    intact    severity    employ    prioritize    function    coordinate    transcriptional    tuning    roles    difficulties    architecture    chromatin    transmit    decode    exists    complexes    clinical    stem    insufficiently    progression    knock    fine    networks    series    paving    underlying   

Project "DeFiNER" data sheet

The following table provides information about the project.

Coordinator
IDRYMA TECHNOLOGIAS KAI EREVNAS 

Organization address
address: N PLASTIRA STR 100
city: IRAKLEIO
postcode: 70013
website: www.forth.gr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Greece [EL]
 Project website http://www.garinislab.gr
 Total cost 1˙995˙000 €
 EC max contribution 1˙995˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-CoG
 Funding Scheme ERC-COG
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2020-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    IDRYMA TECHNOLOGIAS KAI EREVNAS EL (IRAKLEIO) coordinator 1˙995˙000.00

Map

 Project objective

Genome maintenance, chromatin remodelling and transcription are tightly linked biological processes that are currently poorly understood and vastly unexplored. Nucleotide excision repair (NER) is a major DNA repair pathway that mammalian cells employ to maintain their genome intact and faithfully transmit it into their progeny. Besides cancer and aging, however, defects in NER give rise to developmental disorders whose clinical heterogeneity and varying severity can only insufficiently be explained by the DNA repair defect. Recent work reveals that NER factors play a role, in addition to DNA repair, in transcription and the three-dimensional organization of our genome. Indeed, NER factors are now known to function in the regulation of gene expression, the transcriptional reprogramming of pluripotent stem cells and the fine-tuning of growth hormones during mammalian development. In this regard, the non-random organization of our genome, chromatin and the process of transcription itself are expected to play paramount roles in how NER factors coordinate, prioritize and execute their distinct tasks during development and disease progression. At present, however, no solid evidence exists as to how NER is functionally involved in such complex processes, what are the NER-associated protein complexes and underlying gene networks or how NER factors operate within the complex chromatin architecture. This is primarily due to our difficulties in dissecting the diverse functional contributions of NER proteins in an intact organism. Here, we propose to use a unique series of knock-in, transgenic and NER progeroid mice to decode the functional role of NER in mammals, thus paving the way for understanding how genome maintenance pathways are connected to developmental defects and disease mechanisms in vivo.

 Publications

year authors and title journal last update
List of publications.
2017 Kalliopi Stratigi, Ourania Chatzidoukaki, George A. Garinis
DNA damage-induced inflammation and nuclear architecture
published pages: 17-26, ISSN: 0047-6374, DOI: 10.1016/j.mad.2016.09.008
Mechanisms of Ageing and Development 165 2020-03-17
2017 Georgia Chatzinikolaou, Zivkos Apostolou, Tamara Aid-Pavlidis, Anna Ioannidou, Ismene Karakasilioti, Giorgio L. Papadopoulos, Michalis Aivaliotis, Maria Tsekrekou, John Strouboulis, Theodore Kosteas, George A. Garinis
ERCC1–XPF cooperates with CTCF and cohesin to facilitate the developmental silencing of imprinted genes
published pages: 421-432, ISSN: 1465-7392, DOI: 10.1038/ncb3499
Nature Cell Biology 19/5 2020-03-17
2016 Anna Ioannidou, Evi Goulielmaki, George A. Garinis
DNA Damage: From Chronic Inflammation to Age-Related Deterioration
published pages: , ISSN: 1664-8021, DOI: 10.3389/fgene.2016.00187
Frontiers in Genetics 7 2020-03-17

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