Explore the words cloud of the DeFiNER project. It provides you a very rough idea of what is the project "DeFiNER" about.
The following table provides information about the project.
IDRYMA TECHNOLOGIAS KAI EREVNAS
|Coordinator Country||Greece [EL]|
|Total cost||1˙995˙000 €|
|EC max contribution||1˙995˙000 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2016-01-01 to 2020-12-31|
Take a look of project's partnership.
|1||IDRYMA TECHNOLOGIAS KAI EREVNAS||EL (IRAKLEIO)||coordinator||1˙995˙000.00|
Genome maintenance, chromatin remodelling and transcription are tightly linked biological processes that are currently poorly understood and vastly unexplored. Nucleotide excision repair (NER) is a major DNA repair pathway that mammalian cells employ to maintain their genome intact and faithfully transmit it into their progeny. Besides cancer and aging, however, defects in NER give rise to developmental disorders whose clinical heterogeneity and varying severity can only insufficiently be explained by the DNA repair defect. Recent work reveals that NER factors play a role, in addition to DNA repair, in transcription and the three-dimensional organization of our genome. Indeed, NER factors are now known to function in the regulation of gene expression, the transcriptional reprogramming of pluripotent stem cells and the fine-tuning of growth hormones during mammalian development. In this regard, the non-random organization of our genome, chromatin and the process of transcription itself are expected to play paramount roles in how NER factors coordinate, prioritize and execute their distinct tasks during development and disease progression. At present, however, no solid evidence exists as to how NER is functionally involved in such complex processes, what are the NER-associated protein complexes and underlying gene networks or how NER factors operate within the complex chromatin architecture. This is primarily due to our difficulties in dissecting the diverse functional contributions of NER proteins in an intact organism. Here, we propose to use a unique series of knock-in, transgenic and NER progeroid mice to decode the functional role of NER in mammals, thus paving the way for understanding how genome maintenance pathways are connected to developmental defects and disease mechanisms in vivo.
|year||authors and title||journal||last update|
Kalliopi Stratigi, Ourania Chatzidoukaki, George A. Garinis
DNA damage-induced inflammation and nuclear architecture
published pages: 17-26, ISSN: 0047-6374, DOI: 10.1016/j.mad.2016.09.008
|Mechanisms of Ageing and Development 165||2020-03-17|
Georgia Chatzinikolaou, Zivkos Apostolou, Tamara Aid-Pavlidis, Anna Ioannidou, Ismene Karakasilioti, Giorgio L. Papadopoulos, Michalis Aivaliotis, Maria Tsekrekou, John Strouboulis, Theodore Kosteas, George A. Garinis
ERCC1â€“XPF cooperates with CTCF and cohesin toÂ facilitate the developmental silencing of imprintedÂ genes
published pages: 421-432, ISSN: 1465-7392, DOI: 10.1038/ncb3499
|Nature Cell Biology 19/5||2020-03-17|
Anna Ioannidou, Evi Goulielmaki, George A. Garinis
DNA Damage: From Chronic Inflammation to Age-Related Deterioration
published pages: , ISSN: 1664-8021, DOI: 10.3389/fgene.2016.00187
|Frontiers in Genetics 7||2020-03-17|
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "DEFINER" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (firstname.lastname@example.org) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "DEFINER" are provided by the European Opendata Portal: CORDIS opendata.