Explore the words cloud of the U-PGx project. It provides you a very rough idea of what is the project "U-PGx" about.
The following table provides information about the project.
Coordinator |
ACADEMISCH ZIEKENHUIS LEIDEN
Organization address contact info |
Coordinator Country | Netherlands [NL] |
Project website | http://upgx.eu |
Total cost | 14˙936˙613 € |
EC max contribution | 14˙936˙613 € (100%) |
Programme |
1. H2020-EU.3.1.6. (Health care provision and integrated care) |
Code Call | H2020-PHC-2015-two-stage |
Funding Scheme | RIA |
Starting year | 2016 |
Duration (year-month-day) | from 2016-01-01 to 2020-12-31 |
Take a look of project's partnership.
Pharmacogenomics is the study of genetic variability affecting an individual’s response to a drug. Its use allows personalized medicine and reduction in ‘trial and error’ prescribing leading to more efficacious, safer and cost-effective drug therapy. The U-PGx consortium will investigate a pre-emptive genotyping approach (that is: multiple pharmacogenomic variants are collected prospectively and embedded into the patients’ electronic record) of a panel of important pharmacogenomic variants as a new model of personalised medicine. To meet this goal we combine existing pharmacogenomics guidelines and novel health IT solutions. Implementation will be conducted at a large scale in seven existing European health care environments and accounts for the diversity in health system organisations and settings. Feasibility, health outcome and cost-effectiveness will be investigated. We will formulate European strategies for improving clinical implementation of pharmacogenomics based on the findings of this project.
Organization of the 1st patient/general public oriented PGx information events | Websites, patent fillings, videos etc. | 2020-04-07 20:35:54 |
Organization of a U-PGx Personalized Medicine Day in France | Websites, patent fillings, videos etc. | 2020-04-07 20:35:53 |
Education programme for non-participants | Websites, patent fillings, videos etc. | 2020-04-07 20:35:54 |
Workshop for participating healthcare professionals | Websites, patent fillings, videos etc. | 2020-04-07 20:35:53 |
Report on predictions from first model | Documents, reports | 2020-04-07 20:35:54 |
updated version of DMP | Open Research Data Pilot | 2020-04-07 20:35:53 |
Organization of a U-PGx Personalized Medicine Day in the UK | Websites, patent fillings, videos etc. | 2020-04-07 20:35:53 |
2nd version of the public-domain web-based PGx information portal | Other | 2020-04-07 20:35:53 |
Summer school including ELSI topics (prepared by WP8) for medical and pharmacy students | Websites, patent fillings, videos etc. | 2020-04-07 20:35:53 |
Validated bioinformatics tool | Other | 2020-04-07 20:35:54 |
ELSI content for a summer school on PGx to be delivered by WP6 | Demonstrators, pilots, prototypes | 2020-04-07 20:35:53 |
Organization of a U-PGx Personalized Medicine Day in Sweden | Websites, patent fillings, videos etc. | 2020-04-07 20:35:54 |
Midterm Review | Documents, reports | 2020-04-07 20:35:54 |
Establishment of PK models for prediction of DDI and genetic polymorphisms on drug exposure for candidate genes included in the U-PGx trial | Documents, reports | 2020-04-07 20:35:54 |
Release of open-source software artefacts for decision support solutions | Other | 2020-04-07 20:35:52 |
first version of DMP | Open Research Data Pilot | 2020-04-07 20:35:52 |
PGx-guidelines therapeutic recommendations and risk-assessments in English | Documents, reports | 2020-04-07 20:35:52 |
set of specifications for the selected PGx assays | Demonstrators, pilots, prototypes | 2020-04-07 20:35:52 |
Report on models identified to be developed | Documents, reports | 2020-04-07 20:35:52 |
Report on detailed analysis of existing information infrastructures and requirements of implementation sites | Documents, reports | 2020-04-07 20:35:52 |
Survey to evaluate the state of PGx knowledge in the 7 participating countries | Documents, reports | 2020-04-07 20:35:52 |
Delivery of decision support solutions including framework for digital infrastructure including secure cloud solutions | Other | 2020-04-07 20:35:52 |
Standardized Electronic Case Record Form (eCRF) | Other | 2020-04-07 20:35:52 |
Organization of a U-PGx Personalized Medicine Day in Austria | Websites, patent fillings, videos etc. | 2020-04-07 20:35:52 |
1st version of the public-domain web-based U-PGx information portal | Other | 2020-04-07 20:35:52 |
Translated patient surveys for the web-based intensive monitoring system | Documents, reports | 2020-04-07 20:35:51 |
Organization of a U-PGx Personalized Medicine Day in Spain | Websites, patent fillings, videos etc. | 2020-04-07 20:35:52 |
Therapeutic recommendations in Dutch, Greek, German, Italian, Slovene and Spanish | Documents, reports | 2020-04-07 20:35:52 |
Promotional video will be produced that visualises and promotes the idea of the idea of personalised medicine and pre-emptive PGx testing | Websites, patent fillings, videos etc. | 2020-04-07 20:35:52 |
Report on ethical issues, guidelines, governance model and principals for patients included in U-PGx | Documents, reports | 2020-04-07 20:35:52 |
Dedicated webpage with secured login access for investigators and study staff | Other | 2020-04-07 20:35:52 |
eLearning program for the train the trainers concept | Other | 2020-04-07 20:35:52 |
Report on interoperability and development of a shared semantic model | Documents, reports | 2020-04-07 20:35:52 |
Analysis of European regulatory requirements | Documents, reports | 2020-04-07 20:35:52 |
List of relevant genetic variants for pre-emptive PGx testing | Documents, reports | 2020-04-07 20:35:52 |
Report on ELSI education needs | Documents, reports | 2020-04-07 20:35:52 |
Take a look to the deliverables list in detail: detailed list of U-PGx deliverables.
year | authors and title | journal | last update |
---|---|---|---|
2018 |
Volker M. Lauschke, Magnus Ingelman-Sundberg How to Consider Rare Genetic Variants in Personalized Drug Therapy published pages: 745-748, ISSN: 0009-9236, DOI: 10.1002/cpt.976 |
Clinical Pharmacology & Therapeutics 103/5 | 2020-04-07 |
2018 |
Volker M. Lauschke, Isabel Barragan, Magnus Ingelman-Sundberg Pharmacoepigenetics and Toxicoepigenetics: Novel Mechanistic Insights and Therapeutic Opportunities published pages: 161-185, ISSN: 0362-1642, DOI: 10.1146/annurev-pharmtox-010617-053021 |
Annual Review of Pharmacology and Toxicology 58/1 | 2020-04-07 |
2018 |
Marin M. Jukić, Tore Haslemo, Espen Molden, Magnus Ingelman-Sundberg Impact of CYP2C19 Genotype on Escitalopram Exposure and Therapeutic Failure: A Retrospective Study Based on 2,087 Patients published pages: 463-470, ISSN: 0002-953X, DOI: 10.1176/appi.ajp.2017.17050550 |
American Journal of Psychiatry 175/5 | 2020-04-07 |
2017 |
MarÃa Santos, Mikko Niemi, Masahiro Hiratsuka, Masaki Kumondai, Magnus Ingelman-Sundberg, Volker M Lauschke, Cristina RodrÃguez-Antona Novel copy-number variations in pharmacogenes contribute to interindividual differences in drug pharmacokinetics published pages: 622-629, ISSN: 1098-3600, DOI: 10.1038/gim.2017.156 |
Genetics in Medicine 20/6 | 2020-04-07 |
2018 |
Rossana Roncato, Erika Cecchin, Giuseppe Toffoli Improving decision making on DPYD and UGT1A1*28  patients’ profiling with an innovative reimbursement strategy published pages: 301-304, ISSN: 1462-2416, DOI: 10.2217/pgs-2017-0303 |
Pharmacogenomics 19/4 | 2020-04-07 |
2018 |
George P Patrinos Population pharmacogenomics: impact on public health and drug development published pages: 3-6, ISSN: 1462-2416, DOI: 10.2217/pgs-2017-0166 |
Pharmacogenomics 19/1 | 2020-04-07 |
2018 |
Matthew P. Goetz, Katrin Sangkuhl, Henk-Jan Guchelaar, Matthias Schwab, Michael Province, Michelle Whirl-Carrillo, W. Fraser Symmans, Howard L. McLeod, Mark J. Ratain, Hitoshi Zembutsu, Andrea Gaedigk, Ron H. van Schaik, James N. Ingle, Kelly E. Caudle, Teri E. Klein Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and Tamoxifen Therapy published pages: 770-777, ISSN: 0009-9236, DOI: 10.1002/cpt.1007 |
Clinical Pharmacology & Therapeutics 103/5 | 2020-04-07 |
2018 |
Volker M. Lauschke, Lili Milani, Magnus Ingelman-Sundberg Pharmacogenomic Biomarkers for Improved Drug Therapy—Recent Progress and Future Developments published pages: , ISSN: 1550-7416, DOI: 10.1208/s12248-017-0161-x |
The AAPS Journal 20/1 | 2020-04-07 |
2018 |
Kathrin Blagec, Rudolf Koopmann, Mandy Crommentuijn – van Rhenen, Inge Holsappel, Cathelijne H van der Wouden, Lidija Konta, Hong Xu, Daniela Steinberger, Enrico Just, Jesse J Swen, Henk-Jan Guchelaar, Matthias Samwald Implementing pharmacogenomics decision support across seven European countries: The Ubiquitous Pharmacogenomics (U-PGx) project published pages: 893-898, ISSN: 1067-5027, DOI: 10.1093/jamia/ocy005 |
Journal of the American Medical Informatics Association 25/7 | 2020-04-07 |
2017 |
Volker M. Lauschke, Maxim Ivanov, Magnus Ingelman-Sundberg Pitfalls and Opportunities for Epigenomic Analyses Focused on Disease Diagnosis, Prognosis, and Therapy published pages: 765-770, ISSN: 0165-6147, DOI: 10.1016/j.tips.2017.05.007 |
Trends in Pharmacological Sciences 38/9 | 2020-04-07 |
2017 |
Vasilios Fragoulakis, Christina Mitropoulou, Daphne Katelidou, Ron H. van Schaik, Nikolaos Maniadakis, George P. Patrinos Performance Ratio Based Resource Allocation Decision-Making in Genomic Medicine published pages: 67-73, ISSN: 1536-2310, DOI: 10.1089/omi.2016.0161 |
OMICS: A Journal of Integrative Biology 21/2 | 2020-04-07 |
2018 |
Thomas O. Bergmeijer, Jean-Luc Reny, Ruth E. Pakyz, Li Gong, Joshua P. Lewis, Eun-Young Kim, Daniel Aradi, Israel Fernandez-Cadenas, Richard B. Horenstein, Ming Ta Michael Lee, Ryan M. Whaley, Joan Montaner, Gian Franco Gensini, John H. Cleator, Kiyuk Chang, Lene Holmvang, Willibald Hochholzer, Dan M. Roden, Stefan Winter, Russ B. Altman, Dimitrios Alexopoulos, Ho-Sook Kim, Jean-Pierre Déry, Mein Genome-wide and candidate gene approaches of clopidogrel efficacy using pharmacodynamic and clinical end points—Rationale and design of the International Clopidogrel Pharmacogenomics Consortium (ICPC) published pages: 152-159, ISSN: 0002-8703, DOI: 10.1016/j.ahj.2017.12.010 |
American Heart Journal 198 | 2020-04-07 |
2018 |
Ryoichi Fujiwara, Mathias Haag, Elke Schaeffeler, Anne T. Nies, Ulrich M. Zanger, Matthias Schwab Systemic regulation of bilirubin homeostasis: Potential benefits of hyperbilirubinemia published pages: 1609-1619, ISSN: 0270-9139, DOI: 10.1002/hep.29599 |
Hepatology 67/4 | 2020-04-07 |
2017 |
Rollinson V, Turner R, Pirmohamed M Pharmacogenomics: an overview published pages: , ISSN: 2053-6178, DOI: 10.1211/CP.2017.20203640 |
Clinical Pharmacist | 2020-04-07 |
2018 |
Hannah Rieger, Patrik Schmidt, Elke Schaeffeler, Manabu Abe, Mira Schiffhauer, Matthias Schwab, Nicolas von Ahsen, Gabriela Zurek, Hartmut Kirchherr, Maria Shipkova, Eberhard Wieland Validation of a high-performance liquid chromatography method for thiopurine S-methyltransferase activity in whole blood using 6-mercaptopurine as substrate published pages: 803-809, ISSN: 1434-6621, DOI: 10.1515/cclm-2017-0670 |
Clinical Chemistry and Laboratory Medicine (CCLM) 56/5 | 2020-04-07 |
2018 |
Oliver Burk, Maria Kuzikov, Thales Kronenberger, Judith Jeske, Oliver Keminer, Wolfgang E. Thasler, Matthias Schwab, Carsten Wrenger, Björn Windshügel Identification of approved drugs as potent inhibitors of pregnane X receptor activation with differential receptor interaction profiles published pages: 1435-1451, ISSN: 0340-5761, DOI: 10.1007/s00204-018-2165-4 |
Archives of Toxicology 92/4 | 2020-04-07 |
2017 |
GP Patrinos, C Mitropoulou Measuring the Value of Pharmacogenomics Evidence published pages: 739-741, ISSN: 0009-9236, DOI: 10.1002/cpt.743 |
Clinical Pharmacology & Therapeutics 102/5 | 2020-04-07 |
2018 |
Theodora Katsila, Michalis Liontos, George P. Patrinos, Aristotelis Bamias, Dimitrios Kardamakis The New Age of -omics in Urothelial Cancer – Re-wording Its Diagnosis and Treatment published pages: 43-50, ISSN: 2352-3964, DOI: 10.1016/j.ebiom.2018.01.044 |
EBioMedicine 28 | 2020-04-07 |
2018 |
Elena De Mattia, Eva Dreussi, Marcella Montico, Sara Gagno, Chiara Zanusso, Luca Quartuccio, Salvatore De Vita, Michela Guardascione, Angela Buonadonna, Mario D’Andrea, Nicoletta Pella, Adolfo Favaretto, Enrico Mini, Stefania Nobili, Loredana Romanato, Erika Cecchin, Giuseppe Toffoli A Clinical-Genetic Score to Identify Surgically Resected Colorectal Cancer Patients Benefiting From an Adjuvant Fluoropyrimidine-Based Therapy published pages: , ISSN: 1663-9812, DOI: 10.3389/fphar.2018.01101 |
Frontiers in Pharmacology 9 | 2020-04-07 |
2018 |
Giuseppe Toffoli, Federico Innocenti, Jerry Polesel, Elena De Mattia, Franca Sartor, Chiara Dalle Fratte, Fabrizio Ecca, Eva Dreussi, Elisa Palazzari, Michela Guardascione, Angela Buonadonna, Luisa Foltran, Marica Garziera, Alessia Bignucolo, Stefania Nobili, Enrico Mini, Adolfo Favaretto, Massimiliano Berretta, Mario D\'Andrea, Antonino De Paoli, Rossana Roncato, Erika Cecchin The Genotype for DPYD Risk Variants in Patients With Colorectal Cancer and the Related Toxicity Management Costs in Clinical Practice published pages: , ISSN: 0009-9236, DOI: 10.1002/cpt.1257 |
Clinical Pharmacology & Therapeutics | 2020-04-07 |
2018 |
Jun J. Yang, Michelle Whirl-Carrillo, Stuart A. Scott, Amy J. Turner, Matthias Schwab, Yoichi Tanaka, Guilherme Suarez-Kurtz, Elke Schaeffeler, Teri E. Klein, Neil A. Miller, Andrea Gaedigk Pharmacogene Variation Consortium Gene Introduction: NUDT15 published pages: , ISSN: 0009-9236, DOI: 10.1002/cpt.1268 |
Clinical Pharmacology & Therapeutics | 2020-04-07 |
2018 |
Malaz Gazzaz, Martina Kinzig, Elke Schaeffeler, Martin Jübner, Chih-hsuan Hsin, Xia Li, Max Taubert, Christina Trueck, Juliane Iltgen-Breburda, Daria Kraus, Christian Queckenberg, Marc Stoffel, Matthias Schwab, Fritz Sörgel, Uwe Fuhr Drinking Ethanol Has Few Acute Effects on CYP2C9, CYP2C19, NAT2, and P-Glycoprotein Activities but Somewhat Inhibits CYP1A2, CYP2D6, and Intestinal CYP3A: So What? published pages: 1249-1259, ISSN: 0009-9236, DOI: 10.1002/cpt.1083 |
Clinical Pharmacology & Therapeutics 104/6 | 2020-04-07 |
2018 |
Yitian Zhou, Reedik Mägi, Lili Milani, Volker M. Lauschke Global genetic diversity of human apolipoproteins and effects on cardiovascular disease risk published pages: 1987-2000, ISSN: 0022-2275, DOI: 10.1194/jlr.p086710 |
Journal of Lipid Research 59/10 | 2020-04-07 |
2018 |
Yitian Zhou, Volker M Lauschke Comprehensive overview of the pharmacogenetic diversity in Ashkenazi Jews published pages: 617-627, ISSN: 0022-2593, DOI: 10.1136/jmedgenet-2018-105429 |
Journal of Medical Genetics 55/9 | 2020-04-07 |
2018 |
Holger Fröhlich, Rudi Balling, Niko Beerenwinkel, Oliver Kohlbacher, Santosh Kumar, Thomas Lengauer, Marloes H. Maathuis, Yves Moreau, Susan A. Murphy, Teresa M. Przytycka, Michael Rebhan, Hannes Röst, Andreas Schuppert, Matthias Schwab, Rainer Spang, Daniel Stekhoven, Jimeng Sun, Andreas Weber, Daniel Ziemek, Blaz Zupan From hype to reality: data science enabling personalized medicine published pages: , ISSN: 1741-7015, DOI: 10.1186/s12916-018-1122-7 |
BMC Medicine 16/1 | 2020-04-07 |
2018 |
Konstantinos Assimakopoulos, Katerina Karaivazoglou, Maria Skokou, Marina Kalogeropoulou, Panagiotis Kolios, Philippos Gourzis, George Patrinos, Evangelia Tsermpini Genetic Variations Associated with Sleep Disorders in Patients with Schizophrenia: A Systematic Review published pages: 27, ISSN: 2305-6320, DOI: 10.3390/medicines5020027 |
Medicines 5/2 | 2020-04-07 |
2018 |
Yitian Zhou, Souren Mkrtchian, Masaki Kumondai, Masahiro Hiratsuka, Volker M. Lauschke An optimized prediction framework to assess the functional impact of pharmacogenetic variants published pages: , ISSN: 1470-269X, DOI: 10.1038/s41397-018-0044-2 |
The Pharmacogenomics Journal | 2020-04-07 |
2018 |
Asan Agibetov, Kathrin Blagec, Hong Xu, Matthias Samwald Fast and scalable neural embedding models for biomedical sentence classification published pages: , ISSN: 1471-2105, DOI: 10.1186/s12859-018-2496-4 |
BMC Bioinformatics 19/1 | 2020-04-07 |
2019 |
Tore Haslemo, Erik Eliasson, Marin M. Jukić, Magnus Ingelman-Sundberg, Espen Molden Significantly lower CYP2D6 metabolism measured as the O/N -desmethylvenlafaxine metabolic ratio in carriers of CYP2D6*41 versus CYP2D6*9 or CYP2D6*10 : a study on therapeutic drug monitoring data from 1003 genotyped Scandinavian patients published pages: 194-201, ISSN: 0306-5251, DOI: 10.1111/bcp.13788 |
British Journal of Clinical Pharmacology 85/1 | 2020-04-07 |
2018 |
Irena Prodan Žitnik, Darko ÄŒerne, Irene Mancini, Lisa Simi, Mario Pazzagli, Chiara Di Resta, Helena Podgornik, Barbka RepiÄ Lampret, Katarina TrebuÅ¡ak PodkrajÅ¡ek, Csilla Sipeky, Ron van Schaik, Ivan Brandslund, Pieter Vermeersch, Matthias Schwab, Janja Marc Personalized laboratory medicine: a patient-centered future approach published pages: 1981-1991, ISSN: 1434-6621, DOI: 10.1515/cclm-2018-0181 |
Clinical Chemistry and Laboratory Medicine (CCLM) 56/12 | 2020-04-07 |
2019 |
Elke Schaeffeler, Simon U. Jaeger, Verena Klumpp, Jun J. Yang, Svitlana Igel, Laura Hinze, Martin Stanulla, Matthias Schwab Impact of NUDT15 genetics on severe thiopurine-related hematotoxicity in patients with European ancestry published pages: , ISSN: 1098-3600, DOI: 10.1038/s41436-019-0448-7 |
Genetics in Medicine | 2020-04-07 |
2018 |
Yitian Zhou, Kohei Fujikura, Souren Mkrtchian, Volker M. Lauschke Computational Methods for the Pharmacogenetic Interpretation of Next Generation Sequencing Data published pages: , ISSN: 1663-9812, DOI: 10.3389/fphar.2018.01437 |
Frontiers in Pharmacology 9 | 2020-04-07 |
2019 |
Michael Ramharter, Matthias Schwab, Ghyslain Mombo-Ngoma, Rella Zoleko Manego, Daisy Akerey-Diop, Arti Basra, Jean-Rodolphe Mackanga, Heike Würbel, Jan-Georg Wojtyniak, Raquel Gonzalez, Ute Hofmann, Mirjam Geditz, Pierre-Blaise Matsiegui, Peter G. Kremsner, Clara Menendez, Reinhold Kerb, Thorsten Lehr Population Pharmacokinetics of Mefloquine Intermittent Preventive Treatment for Malaria in Pregnancy in Gabon published pages: e01113-18, ISSN: 0066-4804, DOI: 10.1128/aac.01113-18 |
Antimicrobial Agents and Chemotherapy 63/2 | 2020-04-07 |
2018 |
Erika Cecchin, Elena De Mattia, Fabrizio Ecca, Giuseppe Toffoli Host genetic profiling to increase drug safety in colorectal cancer from discovery to implementation published pages: 18-40, ISSN: 1368-7646, DOI: 10.1016/j.drup.2018.07.001 |
Drug Resistance Updates 39 | 2020-04-07 |
2018 |
Marin M Jukic, Volker M Lauschke, Takahiro Saito, Masahiro Hiratsuka, Magnus Ingelman-Sundberg Functional characterization of CYP2D7 gene variants published pages: 931-936, ISSN: 1462-2416, DOI: 10.2217/pgs-2018-0065 |
Pharmacogenomics 19/12 | 2020-04-07 |
2018 |
Magnus Ingelman-Sundberg, Souren Mkrtchian, Yitian Zhou, Volker M. Lauschke Integrating rare genetic variants into pharmacogenetic drug response predictions published pages: , ISSN: 1479-7364, DOI: 10.1186/s40246-018-0157-3 |
Human Genomics 12/1 | 2020-04-07 |
2018 |
Pascale Fisel, Elke Schaeffeler, Matthias Schwab Clinical and Functional Relevance of the Monocarboxylate Transporter Family in Disease Pathophysiology and Drug Therapy published pages: 352-364, ISSN: 1752-8054, DOI: 10.1111/cts.12551 |
Clinical and Translational Science 11/4 | 2020-04-07 |
2018 |
Theodora Katsila, George P. Patrinos, Dimitrios Kardamakis Searching for Clinically Relevant Biomarkers in Geriatric Oncology published pages: 1-7, ISSN: 2314-6133, DOI: 10.1155/2018/3793154 |
BioMed Research International 2018 | 2020-04-07 |
2019 |
Boyao Zhang, Volker M. Lauschke Genetic variability and population diversity of the human SLCO (OATP) transporter family published pages: 550-559, ISSN: 1043-6618, DOI: 10.1016/j.phrs.2018.10.017 |
Pharmacological Research 139 | 2020-04-07 |
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The information about "U-PGX" are provided by the European Opendata Portal: CORDIS opendata.