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ZF-BrainReg SIGNED

Regeneration of the adult zebrafish brain

Total Cost €

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EC-Contrib. €

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Partnership

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Project "ZF-BrainReg" data sheet

The following table provides information about the project.

Coordinator
TECHNISCHE UNIVERSITAET DRESDEN 

Organization address
address: HELMHOLTZSTRASSE 10
city: DRESDEN
postcode: 1069
website: http://www.tu-dresden.de/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website http://www.crt-dresden.de
 Total cost 2˙500˙000 €
 EC max contribution 2˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-ADG
 Funding Scheme ERC-ADG
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2020-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TECHNISCHE UNIVERSITAET DRESDEN DE (DRESDEN) coordinator 2˙500˙000.00

Map

 Project objective

The goal of this research proposal is to unravel the cellular and molecular mechanisms for the ability of the adult zebrafish brain to regenerate itself after a lesion, and to compare these mechanisms in the non-regenerating mammalian brain. The corresponding mechanisms, if reactivated, may rekindle regeneration also in mammalian brains. Specifically, we focus on identifying the endogeneous stem and progenitor cells that contribute to neural regeneration in zebrafish, by genetic lineage tracing experiments under conditions of regeneration. We have begun to identify the genes and mechanisms controlling regeneration ability in these cells by transcriptome analysis of specific cell types isolated by FACS sorting and transcriptome analysis, which has revealed a key positive role for inflammation as a trigger in regeneration. The resulting candidate genes are functionally tested in adult zebrafish brains for their requirement and sufficiency to elicit or contribute to brain regeneration. If confirmed, we will test for the function of such genes and mechanism in mammalian tissue culture models of regeneration, and determine in adult mouse brain in vivo whether they are candidates to be tested in mammalian brain regeneration. Functional knock-out, knock-in and viral expression tests of such genes and mechanisms in vivo in mice will determine their ability to rekindle regeneration in the lesioned mammalian brain.

This research proposal will provide fundamental insights into the cellular and molecular mechanisms controlling the process of brain regeneration in vertebrates, and will thus suggest avenues for future progenitor cell-based therapies of the injured or diseased human brain.

 Publications

year authors and title journal last update
List of publications.
2017 Sumeet Pal Singh, Sharan Janjuha, Theresa Hartmann, Özge Kayisoglu, Judith Konantz, Sarah Birke, Priyanka Murawala, Ezzaldin Ahmed Alfar, Kei Murata, Anne Eugster, Naoki Tsuji, Edward R. Morrissey, Michael Brand, Nikolay Ninov
Different developmental histories of beta-cells generate functional and proliferative heterogeneity during islet growth
published pages: 664, ISSN: 2041-1723, DOI: 10.1038/s41467-017-00461-3
Nature Communications 8/1 2019-07-04
2017 Stefano Suzzi, Reiner Ahrendt, Stefan Hans, Svetlana A. Semenova, Saygin Bilican, Shady Sayed, Sylke Winkler, Sandra Spiess, Jan Kaslin, Pertti Panula, Michael Brand
Loss of lrrk2 impairs dopamine catabolism, cell proliferation, and neuronal regeneration in the zebrafish brain
published pages: , ISSN: , DOI: 10.1101/140608
bioRxiv 140608 2019-07-04
2017 Gokul Kesavan, Avinash Chekuru, Anja Machate, Michael Brand
CRISPR/Cas9-Mediated Zebrafish Knock-in as a Novel Strategy to Study Midbrain-Hindbrain Boundary Development
published pages: , ISSN: 1662-5129, DOI: 10.3389/fnana.2017.00052
Frontiers in Neuroanatomy 11 2019-07-04
2017 Karina Geurtzen, Aude Vernet, Andrew Freidin, Martina Rauner, Lorenz C Hofbauer, Jürgen E Schneider, Michael Brand, Franziska Knopf
Immune Suppressive and Bone Inhibitory Effects of Prednisolone in Growing and Regenerating Zebrafish Tissues
published pages: , ISSN: 0884-0431, DOI: 10.1002/jbmr.3231
Journal of Bone and Mineral Research 2019-07-04
2017 Alejandro Pinzon-Olejua, Cornelia Welte, Avinash Chekuru, Viktoria Bosak, Michael Brand, Stefan Hans, Claudia A.O. Stuermer
Cre-inducible site-specific recombination in zebrafish oligodendrocytes
published pages: 41-49, ISSN: 1058-8388, DOI: 10.1002/dvdy.24458
Developmental Dynamics 246/1 2019-07-04
2016 Guruchandar Arulmozhivarman, Martin Stöter, Marc Bickle, Martin Kräter, Manja Wobus, Gerhard Ehninger, Friedrich Stölzel, Michael Brand, Martin Bornhäuser, Nona Shayegi
In Vivo Chemical Screen in Zebrafish Embryos Identifies Regulators of Hematopoiesis Using a Semiautomated Imaging Assay
published pages: 956-964, ISSN: 1087-0571, DOI: 10.1177/1087057116644163
Journal of Biomolecular Screening 21/9 2019-07-04
2017 Guruchandar Arulmozhivarman, Martin Kräter, Manja Wobus, Jens Friedrichs, Elham Pishali Bejestani, Katrin Müller, Katrin Lambert, Dimitra Alexopoulou, Andreas Dahl, Martin Stöter, Marc Bickle, Nona Shayegi, Jochen Hampe, Friedrich Stölzel, Michael Brand, Malte von Bonin, Martin Bornhäuser
Zebrafish In-Vivo Screening for Compounds Amplifying Hematopoietic Stem and Progenitor Cells: - Preclinical Validation in Human CD34+ Stem and Progenitor Cells
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-12360-0
Scientific Reports 7/1 2019-07-04
2016 Peggy Jungke, Stefan Hans, Mansi Gupta, Anja Machate, Daniela Zöller, Michael Brand
Generation of a conditional lima1a allele in zebrafish using the FLEx switch technology
published pages: 19-28, ISSN: 1526-954X, DOI: 10.1002/dvg.22909
genesis 54/1 2019-07-04
2017 Kazunori Ando, Eri Shibata, Stefan Hans, Michael Brand, Atsushi Kawakami
Osteoblast Production by Reserved Progenitor Cells in Zebrafish Bone Regeneration and Maintenance
published pages: 643-650.e3, ISSN: 1534-5807, DOI: 10.1016/j.devcel.2017.10.015
Developmental Cell 43/5 2019-07-04
2017 Jonathan Henninger, Buyung Santoso, Stefan Hans, Ellen Durand, Jessica Moore, Christian Mosimann, Michael Brand, David Traver, Leonard Zon
Clonal fate mapping quantifies the number of haematopoietic stem cells that arise during development
published pages: 17-27, ISSN: 1465-7392, DOI: 10.1038/ncb3444
Nature Cell Biology 19/1 2019-07-04
2018 Viktoria Bosak, Kei Murata, Oliver Bludau, Michael Brand
Role of the immune response in initiating central nervous system regeneration in vertebrates: learning from the fish
published pages: 403-417, ISSN: 0214-6282, DOI: 10.1387/IJDB.180033VB
The International Journal of Developmental Biology 62/6-7-8 2019-07-04
2018 Gokul Kesavan, Juliane Hammer, Stefan Hans, Michael Brand
Targeted knock-in of CreERT2 in zebrafish using CRISPR/Cas9
published pages: 41-50, ISSN: 0302-766X, DOI: 10.1007/s00441-018-2798-x
Cell and Tissue Research 372/1 2019-07-04
2016 Jan Kaslin, Michael Brand
The Zebrafish Cerebellum
published pages: 411-421, ISSN: , DOI: 10.1007/978-3-319-24551-5_56
Essentials of Cerebellum and Cerebellar Disorders 2019-05-10
2018 Emília Rita Szabó, Michael Brand, Stefan Hans, Katalin Hideghéty, Leonhard Karsch, Elisabeth Lessmann, Jörg Pawelke, Michael Schürer, Elke Beyreuther
Radiobiological effects and proton RBE determined by wildtype zebrafish embryos
published pages: e0206879, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0206879
PLOS ONE 13/11 2019-04-10

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