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ComplexSex SIGNED

Sex-limited experimental evolution of natural and novel sex chromosomes: the role of sex in shaping complex traits

Total Cost €

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EC-Contrib. €

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Partnership

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Project "ComplexSex" data sheet

The following table provides information about the project.

Coordinator
LUNDS UNIVERSITET 

Organization address
address: Paradisgatan 5c
city: LUND
postcode: 22100
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Project website https://www.biology.lu.se/jessica-abbott
 Total cost 1˙492˙011 €
 EC max contribution 1˙492˙011 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-STG
 Funding Scheme ERC-STG
 Starting year 2016
 Duration (year-month-day) from 2016-05-01   to  2021-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LUNDS UNIVERSITET SE (LUND) coordinator 1˙492˙011.00

Map

 Project objective

The origin and evolution of sexual reproduction and sex differences represents one of the major unsolved problems in evolutionary biology, and although much progress had been made both via theory and empirical research, recent data suggest that sex chromosome evolution may be more complex than previously thought. The concept of sexual antagonism (when there is a positive intersexual genetic correlation in trait expression but opposite fitness effects of the trait(s) in males and females) has become essential to our understanding of sex chromosome evolution. The goal of this proposal is to understand how the interacting effects of sexual antagonism, sex-linked genetic variation, and sex-specific selection shape the genetic architecture of complex traits. I will test the hypotheses that: 1) individual sexually antagonistic loci are common in the genome, both in separate-sexed species and in hermaphrodites, and drive patterns of sexual antagonism often seen on the trait level. 2) That the response to sex-specific selection in sex-linked loci is usually due to standing sexually antagonistic genetic variation. 3) That sexually antagonistic variation is primarily non-additive in nature. To accomplish this, I will use a combination of approaches, including sex-limited experimental evolution of the X chromosome and reciprocal sex chromosome introgression among distantly related populations of Drosophila, quantitative genetic analysis and experimental evolution mimicking the creation of a novel sex chromosome in the hermaphroditic flatworm Macrostomum, and analytical and simulation modeling. This project will serve to confirm or refute the assumption that trait-level sexual antagonism reflects the contributions of many individual sexually antagonistic loci, increase our understanding of the contribution of coevolution of the sex chromosomes to population divergence, and help provide us with a better general understanding of how genotype maps to phenotype.

 Publications

year authors and title journal last update
List of publications.
2018 Colin Olito, Jessica K. Abbott, Crispin Y. Jordan
The interaction between sex-specific selection and local adaptation in species without separate sexes
published pages: 20170426, ISSN: 0962-8436, DOI: 10.1098/rstb.2017.0426
Philosophical Transactions of the Royal Society B: Biological Sciences 373/1757 2019-04-02
2017 Anna K. Nordén
Sex Chromosome Evolution in a Hermaphrodite: Genetic and phenotypic relationships between sex roles
published pages: , ISSN: , DOI:
2019-04-02
2018 Abbott, Jessica; Magalhães, Sara; Rodrigues, Leonor; Alpedrinha, Joao
Will Love Tear Them Apart? Identifying the Eco-Evolutionary Feedbacks of Sexual Traits
published pages: , ISSN: , DOI: 10.20944/PREPRINTS201808.0508.V1
2 2019-04-02
2018 Suvi Ponnikas, Hanna Sigeman, Jessica K. Abbott, Bengt Hansson
Why Do Sex Chromosomes Stop Recombining?
published pages: 492-503, ISSN: 0168-9525, DOI: 10.1016/j.tig.2018.04.001
Trends in Genetics 34/7 2019-04-02
2017 Katrine Koch Lund-Hansen
Experimental Manipulation of Sexual Antagonism in Drosophila melanogaster
published pages: , ISSN: , DOI:
2019-04-02

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The information about "COMPLEXSEX" are provided by the European Opendata Portal: CORDIS opendata.

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