Explore the words cloud of the OptiQ-CanDo project. It provides you a very rough idea of what is the project "OptiQ-CanDo" about.
The following table provides information about the project.
TEL AVIV UNIVERSITY
|Coordinator Country||Israel [IL]|
|Total cost||1˙916˙250 €|
|EC max contribution||1˙916˙250 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2016-07-01 to 2021-06-30|
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|1||TEL AVIV UNIVERSITY||IL (TEL AVIV)||coordinator||1˙916˙250.00|
A major challenge in the field of optical imaging of live cells is to achieve label-free but still fully quantitative measurements, which afford high-resolution morphological and mechanical mapping at the single cell level. In particular, developing efficient, non-subjective, quantitative optical imaging technologies for cancer cell diagnosis is a challenging task. The ground-breaking goal of this research project is to establish a robust experimental toolbox for label-free optical diagnosis and monitoring of live cancer cells in-vitro and their potential of metastasis. Optical interferometry is able to provide a platform for imaging live cells quantitatively without the risk of effects caused by using external contrast agents. By overcoming critical technological barriers, I suggest novel hybrid optical interferometric approaches that provide a powerful nano-sensing tool for label-free quantitative measurement of cancer cells. This will be obtained by recording the dynamic quantitative, three-dimensional sub-nanometric structural and mechanical characterization of live cancer cells in different stages. For this aim, I will develop a novel low-noise broadband, common-path, off-axis interferometric system for sub-nanometric physical thickness and mechanical mapping of live cells in thousands of frames per second. Additionally, I will develop rapid tomographic approach for fully capturing the cell three-dimensional refractive-index distribution, as a tool to characterize cancer progression. Interferometry will be combined with multi-trap holographic optical tweezers and dielectrophoresis to enable complete cell manipulations including full rotation, imaging of non-adherent cells, and mechanical measurement validation. New set of interferometry-based quantitative parameters will be developed to enable characterization of cellular transformations, and used to characterize cancer cells with different metastasis potential, for cell lines and for circulating tumor cells.
|year||authors and title||journal||last update|
Gili Dardikman, Simcha Mirsky, Mor Habaza, Yael Roichman, Natan T. Shaked
Angular phase unwrapping of optically thick objects with a thin dimension
published pages: 3347, ISSN: 1094-4087, DOI: 10.1364/OE.25.003347
|Optics Express 25/4||2019-07-08|
Gili Dardikman, Nir A. Turko, Noa Nativ, Simcha K. Mirsky, Natan T. Shaked
Optimal spatial bandwidth capacity in multiplexed off-axis holography for rapid quantitative phase reconstruction and visualization
published pages: 33400, ISSN: 1094-4087, DOI: 10.1364/OE.25.033400
|Optics Express 25/26||2019-07-08|
Mor Habaza, Michael Kirschbaum, Christian Guernth-Marschner, Gili Dardikman, Itay Barnea, Rafi Korenstein, Claus Duschl, Natan T. Shaked
Rapid 3D Refractive-Index Imaging of Live Cells in Suspension without Labeling Using Dielectrophoretic Cell Rotation
published pages: 1600205, ISSN: 2198-3844, DOI: 10.1002/advs.201600205
|Advanced Science 4/2||2019-07-08|
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