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OptiQ-CanDo SIGNED

Hybrid Optical Interferometry for Quantitative Cancer Cell Diagnosis

Total Cost €

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EC-Contrib. €

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Partnership

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Project "OptiQ-CanDo" data sheet

The following table provides information about the project.

Coordinator
TEL AVIV UNIVERSITY 

Organization address
address: RAMAT AVIV
city: TEL AVIV
postcode: 69978
website: http://www.tau.ac.il/

contact info
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surname: n.a.
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 Coordinator Country Israel [IL]
 Project website http://www.eng.tau.ac.il/
 Total cost 1˙916˙250 €
 EC max contribution 1˙916˙250 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-STG
 Funding Scheme ERC-STG
 Starting year 2016
 Duration (year-month-day) from 2016-07-01   to  2021-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TEL AVIV UNIVERSITY IL (TEL AVIV) coordinator 1˙916˙250.00

Map

 Project objective

A major challenge in the field of optical imaging of live cells is to achieve label-free but still fully quantitative measurements, which afford high-resolution morphological and mechanical mapping at the single cell level. In particular, developing efficient, non-subjective, quantitative optical imaging technologies for cancer cell diagnosis is a challenging task. The ground-breaking goal of this research project is to establish a robust experimental toolbox for label-free optical diagnosis and monitoring of live cancer cells in-vitro and their potential of metastasis. Optical interferometry is able to provide a platform for imaging live cells quantitatively without the risk of effects caused by using external contrast agents. By overcoming critical technological barriers, I suggest novel hybrid optical interferometric approaches that provide a powerful nano-sensing tool for label-free quantitative measurement of cancer cells. This will be obtained by recording the dynamic quantitative, three-dimensional sub-nanometric structural and mechanical characterization of live cancer cells in different stages. For this aim, I will develop a novel low-noise broadband, common-path, off-axis interferometric system for sub-nanometric physical thickness and mechanical mapping of live cells in thousands of frames per second. Additionally, I will develop rapid tomographic approach for fully capturing the cell three-dimensional refractive-index distribution, as a tool to characterize cancer progression. Interferometry will be combined with multi-trap holographic optical tweezers and dielectrophoresis to enable complete cell manipulations including full rotation, imaging of non-adherent cells, and mechanical measurement validation. New set of interferometry-based quantitative parameters will be developed to enable characterization of cellular transformations, and used to characterize cancer cells with different metastasis potential, for cell lines and for circulating tumor cells.

 Publications

year authors and title journal last update
List of publications.
2017 Gili Dardikman, Simcha Mirsky, Mor Habaza, Yael Roichman, Natan T. Shaked
Angular phase unwrapping of optically thick objects with a thin dimension
published pages: 3347, ISSN: 1094-4087, DOI: 10.1364/OE.25.003347
Optics Express 25/4 2019-07-08
2017 Gili Dardikman, Nir A. Turko, Noa Nativ, Simcha K. Mirsky, Natan T. Shaked
Optimal spatial bandwidth capacity in multiplexed off-axis holography for rapid quantitative phase reconstruction and visualization
published pages: 33400, ISSN: 1094-4087, DOI: 10.1364/OE.25.033400
Optics Express 25/26 2019-07-08
2017 Mor Habaza, Michael Kirschbaum, Christian Guernth-Marschner, Gili Dardikman, Itay Barnea, Rafi Korenstein, Claus Duschl, Natan T. Shaked
Rapid 3D Refractive-Index Imaging of Live Cells in Suspension without Labeling Using Dielectrophoretic Cell Rotation
published pages: 1600205, ISSN: 2198-3844, DOI: 10.1002/advs.201600205
Advanced Science 4/2 2019-07-08

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