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HOLDING-HANDS SIGNED

Holding hands: cell-cell junctions in breast cancer metastasis and resistance to therapy

Total Cost €

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EC-Contrib. €

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Partnership

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 HOLDING-HANDS project word cloud

Explore the words cloud of the HOLDING-HANDS project. It provides you a very rough idea of what is the project "HOLDING-HANDS" about.

involvement    components    patient    cldn3    et    block    occurs    desmosome    junctions    metastasis    break    spread    largely    tjp2    driving    lesion    therapies    500000    unappreciated    notion    signaling    ing    cells    mechanisms    tight    sites    fundamental    tumor    patients    samples    suggest    targetable    shown    cancer    incurable    off    desmosomes    deposits    actively    previously    migratory    single    al    therapeutic    questions    worldwide    cross    class    cellular    goals    2014    types    mouse    unequivocally    options    science    breast    boundaries    predominant    disease    blood    times    die    prevent    dsg2    primary    primarily    unprecedented    site    basic    cell    data    ambition    mechanism    dominated    disseminate    groupings    agents    distant    symptoms    form    models    junction    metastases    metastatic    therapy    critical    vivo    aceto    preliminary    women    unexpectedly    first    highlight    deaths    clinical   

Project "HOLDING-HANDS" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAT BASEL 

Organization address
address: PETERSPLATZ 1
city: BASEL
postcode: 4051
website: www.unibas.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
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 Coordinator Country Switzerland [CH]
 Project website http://www.cancermetastasislab.com/
 Total cost 1˙744˙921 €
 EC max contribution 1˙744˙921 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-STG
 Funding Scheme ERC-STG
 Starting year 2016
 Duration (year-month-day) from 2016-03-01   to  2021-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAT BASEL CH (BASEL) coordinator 1˙744˙921.00

Map

 Project objective

Breast cancer is the most common cancer in women, resulting in as many as 500000 deaths per year worldwide. Patients with breast cancer die unequivocally because of the development of incurable distant metastases and not because of symptoms related to the primary site. Understanding the complex, yet fundamental mechanisms driving breast cancer metastasis is critical to develop therapies tailored to this disease. The current understanding of how metastasis occurs is derived primarily from mouse models and largely dominated by the notion that single migratory cancer cells within the primary tumor can actively disseminate to distant sites and develop as metastatic deposits. Unexpectedly, our very recent study on patient blood samples has shown that cancer cell groupings, held together through strong cell-cell junctions, can break off the primary tumor and form a metastatic lesion up to 50 times more efficiently than single migratory cancer cells (Aceto et al, Cell, 2014). These findings lead to new open questions, yet highlight a previously unappreciated and targetable mechanism of cancer dissemination. Our preliminary data suggest that, among all types of cell-cell junctions, desmosomes and tight junctions are involved in this process, and therefore represent unprecedented options for developing a metastasis-tailored therapy for breast cancer. The two predominant goals of this proposal are: first, to define the role of specific desmosome (DSG2) and tight junction (CLDN3 and TJP2) components in the development of metastasis. Second, to address their involvement in cellular signaling and response to therapy. These studies will not only use our first-of-a-kind in vivo models developed from patients with breast cancer metastases, but also cross the boundaries between basic science and clinical applications. Our research has the long-term ambition to lead to a novel class of therapeutic agents tailored to block cell-cell junctions and prevent metastatic spread of cancer.

 Publications

year authors and title journal last update
List of publications.
2019 Gkountela S, Castro-Giner F, Szczerba BM, Vetter M, Landin J, Scherrer R, Krol I, Scheidmann MC, Beisel C, Stirnimann CU, Kurzeder C, Heinzelmann-Schwarz V, Rochlitz C, Weber WP, Aceto N.
Circulating Tumor Cell Clustering Shapes DNA Methylation to Enable Metastasis Seeding
published pages: , ISSN: 0092-8674, DOI:
Cell 2019-10-08
2019 Szczerba BM, Castro-Giner F, Vetter M, Krol I, Gkountela S, Landin J, Scheidmann MC, Donato C, Scherrer R, Singer J, Beisel C, Kurzeder C, Heinzelmann-Schwarz V, Rochlitz C, Weber WP, Beerenwinkel N, Aceto N.
Neutrophils escort circulating tumour cells to enable cell cycle progression
published pages: , ISSN: 0028-0836, DOI:
Nature 2019-10-08

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