DrugCrops
Drought discovery to improve drought tolerance in crops
Total Cost €
0EC-Contrib. €
0Partnership
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0DrugCrops project word cloud
Explore the words cloud of the DrugCrops project. It provides you a very rough idea of what is the project "DrugCrops" about.
Project "DrugCrops" data sheet
The following table provides information about the project.
| Coordinator |
AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS
Organization address contact info |
| Coordinator Country | Spain [ES] |
| Total cost | 158˙121 € |
| EC max contribution | 158˙121 € (100%) |
| Programme |
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility) |
| Code Call | H2020-MSCA-IF-2015 |
| Funding Scheme | MSCA-IF-EF-RI |
| Starting year | 2017 |
| Duration (year-month-day) | from 2017-03-03 to 2019-03-02 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS | ES (MADRID) | coordinator | 158˙121.00 |
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Project objective
Feeding 9 billion people by 2040 in a context of water shortage poses a critical challenge for agricultural practices, particularly under recurrent drought periods. The so-called Blue Revolution -evaluated by UN as an urgent priority- calls to develop innovative solutions to grow staple food crops in water-limited conditions. Increasing temperatures and reduced precipitation have severely impaired crop yields. Plants can be protected against these stresses by the action of the hormone abscisic acid (ABA), which orchestrates a multitude of adaptive responses that enhance plant survival. The major class of ABA receptors has been characterized and structural data are available for the receptors of the model plant Arabidopsis thaliana. However, in crops that provide more than 50% of the diet worldwide, this knowledge is limited. The goal of DrugCrops is to generate and exploit biochemical and structural data of the ABA receptors in the model crop plant Setaria viridis and in maize to develop novel ABA receptor agonists in order to enhance drought tolerance using small molecules. Towards this translational and multidisciplinary goal, we propose the use of high throughput technologies, X-ray crystallographic, chemical and genetic approaches to dissect the mechanism by which agonists engage and activate their receptors. This information will be leveraged for the design of new chemicals that can be used to control abiotic stress tolerance in crop plants. The ER will work in collaboration with different partner research organizations with recognized expertise in ABA signaling, chemical and structural biology that collectively bring experience ranging from big pharma drug discovery to the genetic engineering of drought tolerant crops. As a result, both the ER and Host could obtain new molecules for plant biotechnology in the field of plant drought tolerance, boosting knowledge-based bioeconomy in the EU and ER´s possibilities to reach a position in research.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2017 |
Yu Ling, Sahar Alshareef, Haroon Butt, Jorge Lozano-Juste, Lixin Li, Aya A. Galal, Ahmed Moustafa, Afaque A. Momin, Manal Tashkandi, Dale N. Richardson, Hiroaki Fujii, Stefan Arold, Pedro L. Rodriguez, Paula Duque, Magdy M. Mahfouz Pre-mRNA splicing repression triggers abiotic stress signaling in plants published pages: 291-309, ISSN: 0960-7412, DOI: 10.1111/tpj.13383 |
The Plant Journal 89/2 | 2019-11-14 |
| 2017 |
MarÃa Moreno-Alvero, Cristina Yunta, Miguel Gonzalez-Guzman, Jorge Lozano-Juste, Juan Luis Benavente, Vicent Arbona, Margarita Menéndez, Martin Martinez-Ripoll, Lourdes Infantes, Aurelio Gomez-Cadenas, Pedro L. Rodriguez, Armando Albert Structure of Ligand-Bound Intermediates of Crop ABA Receptors Highlights PP2C as Necessary ABA Co-receptor published pages: 1250-1253, ISSN: 1674-2052, DOI: 10.1016/j.molp.2017.07.004 |
Molecular Plant 10/9 | 2019-11-14 |
| 2019 |
Jorge Lozano-Juste, Marco Masi, Alessio Cimmino, Suzette Clement, Maria A Fernandez, Regina Antoni, Susan Meyer, Pedro L. Rodriguez, Antonio Evidente The fungal sesquiterpenoid pyrenophoric acid B uses the plant ABA biosynthetic pathway to inhibit seed germination. published pages: , ISSN: , DOI: 10.1101/622530 |
2019-11-14 | |
| 2018 |
Borja Belda-Palazon, Mary-Paz Gonzalez-Garcia, Jorge Lozano-Juste, Alberto Coego, Regina Antoni, Jose Julian, Marta Peirats-Llobet, Lesia Rodriguez, Ana Berbel, Daniela Dietrich, Maria A. Fernandez, Francisco Madueño, Malcolm J. Bennett, Pedro L. Rodriguez PYL8 mediates ABA perception in the root through non-cell-autonomous and ligand-stabilization–based mechanisms published pages: E11857-E11863, ISSN: 0027-8424, DOI: 10.1073/pnas.1815410115 |
Proceedings of the National Academy of Sciences 115/50 | 2019-11-14 |
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