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DrugCrops

Drought discovery to improve drought tolerance in crops

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 DrugCrops project word cloud

Explore the words cloud of the DrugCrops project. It provides you a very rough idea of what is the project "DrugCrops" about.

diet    shortage    tolerant    abiotic    water    position    50    plant    drug    drought    chemicals    boosting    biology    survival    critical    worldwide    aba    people    data    generate    hormone    bioeconomy    context    mechanism    er    agonists    translational    un    temperatures    obtain    feeding    thaliana    crops    solutions    periods    host    receptors    small    possibilities    innovative    action    precipitation    setaria    with    protected    receptor    big    crystallographic    multitude    abscisic    engage    plants    biotechnology    2040    orchestrates    impaired    stresses    food    agricultural    acid    crop    practices    dissect    structural    acute    stress    billion    revolution    genetic    throughput    signaling    urgent    expertise    recurrent    model    grow    blue    class    pharma    multidisciplinary    tolerance    biochemical    adaptive    leveraged    collectively    ray    maize    viridis    discovery    molecules    arabidopsis    poses    severely    engineering    drugcrops    ranging    technologies    activate    yields    calls    chemical    limited    staple   

Project "DrugCrops" data sheet

The following table provides information about the project.

Coordinator
AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS 

Organization address
address: CALLE SERRANO 117
city: MADRID
postcode: 28006
website: http://www.csic.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 158˙121 €
 EC max contribution 158˙121 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2017
 Duration (year-month-day) from 2017-03-03   to  2019-03-02

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS ES (MADRID) coordinator 158˙121.00

Map

 Project objective

Feeding 9 billion people by 2040 in a context of water shortage poses a critical challenge for agricultural practices, particularly under recurrent drought periods. The so-called Blue Revolution -evaluated by UN as an urgent priority- calls to develop innovative solutions to grow staple food crops in water-limited conditions. Increasing temperatures and reduced precipitation have severely impaired crop yields. Plants can be protected against these stresses by the action of the hormone abscisic acid (ABA), which orchestrates a multitude of adaptive responses that enhance plant survival. The major class of ABA receptors has been characterized and structural data are available for the receptors of the model plant Arabidopsis thaliana. However, in crops that provide more than 50% of the diet worldwide, this knowledge is limited. The goal of DrugCrops is to generate and exploit biochemical and structural data of the ABA receptors in the model crop plant Setaria viridis and in maize to develop novel ABA receptor agonists in order to enhance drought tolerance using small molecules. Towards this translational and multidisciplinary goal, we propose the use of high throughput technologies, X-ray crystallographic, chemical and genetic approaches to dissect the mechanism by which agonists engage and activate their receptors. This information will be leveraged for the design of new chemicals that can be used to control abiotic stress tolerance in crop plants. The ER will work in collaboration with different partner research organizations with recognized expertise in ABA signaling, chemical and structural biology that collectively bring experience ranging from big pharma drug discovery to the genetic engineering of drought tolerant crops. As a result, both the ER and Host could obtain new molecules for plant biotechnology in the field of plant drought tolerance, boosting knowledge-based bioeconomy in the EU and ER´s possibilities to reach a position in research.

 Publications

year authors and title journal last update
List of publications.
2017 Yu Ling, Sahar Alshareef, Haroon Butt, Jorge Lozano-Juste, Lixin Li, Aya A. Galal, Ahmed Moustafa, Afaque A. Momin, Manal Tashkandi, Dale N. Richardson, Hiroaki Fujii, Stefan Arold, Pedro L. Rodriguez, Paula Duque, Magdy M. Mahfouz
Pre-mRNA splicing repression triggers abiotic stress signaling in plants
published pages: 291-309, ISSN: 0960-7412, DOI: 10.1111/tpj.13383
The Plant Journal 89/2 2019-11-14
2017 María Moreno-Alvero, Cristina Yunta, Miguel Gonzalez-Guzman, Jorge Lozano-Juste, Juan Luis Benavente, Vicent Arbona, Margarita Menéndez, Martin Martinez-Ripoll, Lourdes Infantes, Aurelio Gomez-Cadenas, Pedro L. Rodriguez, Armando Albert
Structure of Ligand-Bound Intermediates of Crop ABA Receptors Highlights PP2C as Necessary ABA Co-receptor
published pages: 1250-1253, ISSN: 1674-2052, DOI: 10.1016/j.molp.2017.07.004
Molecular Plant 10/9 2019-11-14
2019 Jorge Lozano-Juste, Marco Masi, Alessio Cimmino, Suzette Clement, Maria A Fernandez, Regina Antoni, Susan Meyer, Pedro L. Rodriguez, Antonio Evidente
The fungal sesquiterpenoid pyrenophoric acid B uses the plant ABA biosynthetic pathway to inhibit seed germination.
published pages: , ISSN: , DOI: 10.1101/622530
2019-11-14
2018 Borja Belda-Palazon, Mary-Paz Gonzalez-Garcia, Jorge Lozano-Juste, Alberto Coego, Regina Antoni, Jose Julian, Marta Peirats-Llobet, Lesia Rodriguez, Ana Berbel, Daniela Dietrich, Maria A. Fernandez, Francisco Madueño, Malcolm J. Bennett, Pedro L. Rodriguez
PYL8 mediates ABA perception in the root through non-cell-autonomous and ligand-stabilization–based mechanisms
published pages: E11857-E11863, ISSN: 0027-8424, DOI: 10.1073/pnas.1815410115
Proceedings of the National Academy of Sciences 115/50 2019-11-14

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