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SPRAYNERGY

Translational synergistic growth factor microenvironments for bone regeneration

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 SPRAYNERGY project word cloud

Explore the words cloud of the SPRAYNERGY project. It provides you a very rough idea of what is the project "SPRAYNERGY" about.

later    complications    localised    defects    defect    ltd    grant    clinic    gfs    nanometric    fibronectin    critical    cell    rhbmp2    morphogenesis    co    sme    erc    induce    fn    hurdle    doses    construct    enhances    patent    meek    tissue    combination    functional    competitive    pea    engineered    commercial    receptors    scaling    coated    gf    powerful    bone    encountered    engineering    murine    signalling    taragenyx    route    lower    binding    direct    regeneration    spray    commercialisation    ethyl    patients    appraisal    size    planning    simultaneous    morphogenetic    presentation    poly    filed    synergy    degradable    licensed    serious    vascularisation    integrin    material    rhbmp    bulk    region    versatile    acrylate    protein    union    fabricate    clinical    sequester    recombinant    model    stages    safer    safe    surgeon    overcome    shown    translational    stem    integrins    human    polymer    regenerate    dr    standpoint    layer    domain    teamed    differentiation    vivo   

Project "SPRAYNERGY" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF GLASGOW 

Organization address
address: UNIVERSITY AVENUE
city: GLASGOW
postcode: G12 8QQ
website: www.gla.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 148˙783 €
 EC max contribution 148˙783 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-PoC
 Funding Scheme ERC-POC
 Starting year 2016
 Duration (year-month-day) from 2016-06-01   to  2017-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF GLASGOW UK (GLASGOW) coordinator 148˙783.00

Map

 Project objective

We propose a robust polymer-based system that allows a safer delivery of recombinant human bone morphogenetic protein-2 (rhBMP2) for bone tissue engineering. We have teamed up with a surgeon (Dr. Meek) and an SME (Taragenyx Ltd.) in the planning stages, for the appraisal of the proposal from a translational standpoint. Later, Taragenyx will also be involved with scaling-up and commercialisation. We filed a patent covering the technology, and licensed Taragenyx its exploitation. rhBMP2 is a powerful human growth factor (GF) essential in tissue morphogenesis and used to promote bone growth in clinical applications. Current clinical delivery has encountered serious complications associated with the high doses used. We have developed a system that allows the effective presentation of GFs in combination with the integrin binding domain of fibronectin (FN), promoting simultaneous and co-localised signalling between GF receptors and integrins. We have shown the ability of Poly(ethyl acrylate) PEA to organise FN and sequester rhBMP2 in synergy with the integrin binding region to direct stem cell differentiation. This technology enhances bone regeneration and vascularisation with lower rhBMP-2 doses. With this understanding we have engineered a system to regenerate a bone critical size defect in a murine model. Results were comparable to the higher doses used in the clinic, which makes the system safe, effective and more competitive than current commercial products. PEA is however a non-degradable material, a major hurdle to be overcome for many potential applications. We will fabricate a degradable construct spray-coated with a nanometric layer of this functional material to induce and direct bone growth – as already shown for the bulk polymer in our ERC Grant, and investigate in vivo the engineered systems. Overall, we will develop a safe and versatile bone system for clinical use in patients with non-union bone defects, and set a route towards commercialisation.

 Publications

year authors and title journal last update
List of publications.
2018 Zhe A. Cheng, Andres Alba-Perez, Cristina Gonzalez-Garcia, Hannah Donnelly, Virginia Llopis-Hernandez, David W. Shields, Laura Ruiz-Cantu, Andrew Reid, James F. C. Windmill, Elena S. Addison, Sandra Corr, William G. Marshall, Matthew J. Dalby and Manuel Salmeron-Sanchez
Engineering nanoscale coatings for ultra-low-dose BMP-2-driven regeneration of critical-size bone defects
published pages: , ISSN: 2095-6231, DOI:
Nature: Bone Research (In review) 2019-06-14

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