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SPRAYNERGY

Translational synergistic growth factor microenvironments for bone regeneration

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 SPRAYNERGY project word cloud

Explore the words cloud of the SPRAYNERGY project. It provides you a very rough idea of what is the project "SPRAYNERGY" about.

morphogenetic    enhances    spray    gfs    stages    critical    hurdle    safer    integrins    serious    later    complications    taragenyx    surgeon    regenerate    presentation    encountered    doses    safe    lower    domain    defects    meek    protein    versatile    functional    region    binding    tissue    clinical    clinic    recombinant    defect    standpoint    engineered    regeneration    human    rhbmp2    fibronectin    bulk    degradable    commercialisation    overcome    sequester    scaling    planning    ltd    simultaneous    fabricate    dr    synergy    morphogenesis    size    differentiation    nanometric    licensed    layer    translational    polymer    co    teamed    powerful    competitive    cell    filed    shown    ethyl    union    signalling    rhbmp    gf    appraisal    stem    acrylate    sme    fn    vivo    localised    pea    poly    combination    patients    murine    integrin    induce    receptors    coated    construct    patent    erc    engineering    direct    material    route    bone    grant    model    vascularisation    commercial   

Project "SPRAYNERGY" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF GLASGOW 

Organization address
address: UNIVERSITY AVENUE
city: GLASGOW
postcode: G12 8QQ
website: www.gla.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 148˙783 €
 EC max contribution 148˙783 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-PoC
 Funding Scheme ERC-POC
 Starting year 2016
 Duration (year-month-day) from 2016-06-01   to  2017-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF GLASGOW UK (GLASGOW) coordinator 148˙783.00

Map

 Project objective

We propose a robust polymer-based system that allows a safer delivery of recombinant human bone morphogenetic protein-2 (rhBMP2) for bone tissue engineering. We have teamed up with a surgeon (Dr. Meek) and an SME (Taragenyx Ltd.) in the planning stages, for the appraisal of the proposal from a translational standpoint. Later, Taragenyx will also be involved with scaling-up and commercialisation. We filed a patent covering the technology, and licensed Taragenyx its exploitation. rhBMP2 is a powerful human growth factor (GF) essential in tissue morphogenesis and used to promote bone growth in clinical applications. Current clinical delivery has encountered serious complications associated with the high doses used. We have developed a system that allows the effective presentation of GFs in combination with the integrin binding domain of fibronectin (FN), promoting simultaneous and co-localised signalling between GF receptors and integrins. We have shown the ability of Poly(ethyl acrylate) PEA to organise FN and sequester rhBMP2 in synergy with the integrin binding region to direct stem cell differentiation. This technology enhances bone regeneration and vascularisation with lower rhBMP-2 doses. With this understanding we have engineered a system to regenerate a bone critical size defect in a murine model. Results were comparable to the higher doses used in the clinic, which makes the system safe, effective and more competitive than current commercial products. PEA is however a non-degradable material, a major hurdle to be overcome for many potential applications. We will fabricate a degradable construct spray-coated with a nanometric layer of this functional material to induce and direct bone growth – as already shown for the bulk polymer in our ERC Grant, and investigate in vivo the engineered systems. Overall, we will develop a safe and versatile bone system for clinical use in patients with non-union bone defects, and set a route towards commercialisation.

 Publications

year authors and title journal last update
List of publications.
2018 Zhe A. Cheng, Andres Alba-Perez, Cristina Gonzalez-Garcia, Hannah Donnelly, Virginia Llopis-Hernandez, David W. Shields, Laura Ruiz-Cantu, Andrew Reid, James F. C. Windmill, Elena S. Addison, Sandra Corr, William G. Marshall, Matthew J. Dalby and Manuel Salmeron-Sanchez
Engineering nanoscale coatings for ultra-low-dose BMP-2-driven regeneration of critical-size bone defects
published pages: , ISSN: 2095-6231, DOI:
Nature: Bone Research (In review) 2019-06-14

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