Opendata, web and dolomites

SPRAYNERGY

Translational synergistic growth factor microenvironments for bone regeneration

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 SPRAYNERGY project word cloud

Explore the words cloud of the SPRAYNERGY project. It provides you a very rough idea of what is the project "SPRAYNERGY" about.

later    acrylate    direct    regeneration    regenerate    human    dr    recombinant    bone    vascularisation    receptors    size    region    model    serious    planning    complications    doses    rhbmp2    integrins    critical    rhbmp    surgeon    patients    construct    coated    safer    route    simultaneous    stem    tissue    translational    erc    appraisal    safe    bulk    defect    fabricate    signalling    competitive    sequester    synergy    standpoint    ethyl    combination    meek    patent    murine    commercialisation    overcome    pea    defects    induce    ltd    hurdle    gfs    fibronectin    teamed    filed    shown    localised    morphogenesis    presentation    grant    taragenyx    differentiation    engineered    encountered    cell    integrin    powerful    lower    fn    binding    licensed    gf    co    morphogenetic    layer    engineering    scaling    functional    stages    clinic    nanometric    sme    polymer    degradable    vivo    versatile    union    poly    commercial    protein    enhances    domain    clinical    spray    material   

Project "SPRAYNERGY" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF GLASGOW 

Organization address
address: UNIVERSITY AVENUE
city: GLASGOW
postcode: G12 8QQ
website: www.gla.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 148˙783 €
 EC max contribution 148˙783 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-PoC
 Funding Scheme ERC-POC
 Starting year 2016
 Duration (year-month-day) from 2016-06-01   to  2017-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF GLASGOW UK (GLASGOW) coordinator 148˙783.00

Map

 Project objective

We propose a robust polymer-based system that allows a safer delivery of recombinant human bone morphogenetic protein-2 (rhBMP2) for bone tissue engineering. We have teamed up with a surgeon (Dr. Meek) and an SME (Taragenyx Ltd.) in the planning stages, for the appraisal of the proposal from a translational standpoint. Later, Taragenyx will also be involved with scaling-up and commercialisation. We filed a patent covering the technology, and licensed Taragenyx its exploitation. rhBMP2 is a powerful human growth factor (GF) essential in tissue morphogenesis and used to promote bone growth in clinical applications. Current clinical delivery has encountered serious complications associated with the high doses used. We have developed a system that allows the effective presentation of GFs in combination with the integrin binding domain of fibronectin (FN), promoting simultaneous and co-localised signalling between GF receptors and integrins. We have shown the ability of Poly(ethyl acrylate) PEA to organise FN and sequester rhBMP2 in synergy with the integrin binding region to direct stem cell differentiation. This technology enhances bone regeneration and vascularisation with lower rhBMP-2 doses. With this understanding we have engineered a system to regenerate a bone critical size defect in a murine model. Results were comparable to the higher doses used in the clinic, which makes the system safe, effective and more competitive than current commercial products. PEA is however a non-degradable material, a major hurdle to be overcome for many potential applications. We will fabricate a degradable construct spray-coated with a nanometric layer of this functional material to induce and direct bone growth – as already shown for the bulk polymer in our ERC Grant, and investigate in vivo the engineered systems. Overall, we will develop a safe and versatile bone system for clinical use in patients with non-union bone defects, and set a route towards commercialisation.

 Publications

year authors and title journal last update
List of publications.
2018 Zhe A. Cheng, Andres Alba-Perez, Cristina Gonzalez-Garcia, Hannah Donnelly, Virginia Llopis-Hernandez, David W. Shields, Laura Ruiz-Cantu, Andrew Reid, James F. C. Windmill, Elena S. Addison, Sandra Corr, William G. Marshall, Matthew J. Dalby and Manuel Salmeron-Sanchez
Engineering nanoscale coatings for ultra-low-dose BMP-2-driven regeneration of critical-size bone defects
published pages: , ISSN: 2095-6231, DOI:
Nature: Bone Research (In review) 2019-06-14

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "SPRAYNERGY" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "SPRAYNERGY" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

ZARAH (2020)

Women’s labour activism in Eastern Europe and transnationally, from the age of empires to the late 20th century

Read More  

MOCHA (2019)

Understanding and leveraging ‘moments of change’ for pro-environmental behaviour shifts

Read More  

SWIP (2019)

Extended short-wave infrared pulsed fibre laser

Read More