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Translational synergistic growth factor microenvironments for bone regeneration

Total Cost €


EC-Contrib. €






 SPRAYNERGY project word cloud

Explore the words cloud of the SPRAYNERGY project. It provides you a very rough idea of what is the project "SPRAYNERGY" about.

surgeon    ltd    localised    signalling    layer    nanometric    region    differentiation    induce    combination    later    size    vascularisation    bulk    stages    domain    engineering    material    sequester    presentation    grant    patients    scaling    pea    complications    teamed    morphogenesis    fn    encountered    construct    sme    doses    safer    stem    direct    coated    translational    polymer    gfs    taragenyx    degradable    recombinant    bone    integrins    integrin    tissue    acrylate    regeneration    shown    safe    human    union    filed    cell    hurdle    erc    enhances    rhbmp    licensed    appraisal    commercial    serious    binding    clinical    versatile    engineered    regenerate    fibronectin    protein    competitive    vivo    morphogenetic    model    receptors    co    planning    meek    defects    powerful    functional    clinic    murine    simultaneous    dr    commercialisation    rhbmp2    gf    standpoint    overcome    spray    defect    poly    synergy    critical    ethyl    fabricate    route    patent    lower   

Project "SPRAYNERGY" data sheet

The following table provides information about the project.


Organization address
postcode: G12 8QQ

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 148˙783 €
 EC max contribution 148˙783 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-PoC
 Funding Scheme ERC-POC
 Starting year 2016
 Duration (year-month-day) from 2016-06-01   to  2017-11-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF GLASGOW UK (GLASGOW) coordinator 148˙783.00


 Project objective

We propose a robust polymer-based system that allows a safer delivery of recombinant human bone morphogenetic protein-2 (rhBMP2) for bone tissue engineering. We have teamed up with a surgeon (Dr. Meek) and an SME (Taragenyx Ltd.) in the planning stages, for the appraisal of the proposal from a translational standpoint. Later, Taragenyx will also be involved with scaling-up and commercialisation. We filed a patent covering the technology, and licensed Taragenyx its exploitation. rhBMP2 is a powerful human growth factor (GF) essential in tissue morphogenesis and used to promote bone growth in clinical applications. Current clinical delivery has encountered serious complications associated with the high doses used. We have developed a system that allows the effective presentation of GFs in combination with the integrin binding domain of fibronectin (FN), promoting simultaneous and co-localised signalling between GF receptors and integrins. We have shown the ability of Poly(ethyl acrylate) PEA to organise FN and sequester rhBMP2 in synergy with the integrin binding region to direct stem cell differentiation. This technology enhances bone regeneration and vascularisation with lower rhBMP-2 doses. With this understanding we have engineered a system to regenerate a bone critical size defect in a murine model. Results were comparable to the higher doses used in the clinic, which makes the system safe, effective and more competitive than current commercial products. PEA is however a non-degradable material, a major hurdle to be overcome for many potential applications. We will fabricate a degradable construct spray-coated with a nanometric layer of this functional material to induce and direct bone growth – as already shown for the bulk polymer in our ERC Grant, and investigate in vivo the engineered systems. Overall, we will develop a safe and versatile bone system for clinical use in patients with non-union bone defects, and set a route towards commercialisation.


year authors and title journal last update
List of publications.
2018 Zhe A. Cheng, Andres Alba-Perez, Cristina Gonzalez-Garcia, Hannah Donnelly, Virginia Llopis-Hernandez, David W. Shields, Laura Ruiz-Cantu, Andrew Reid, James F. C. Windmill, Elena S. Addison, Sandra Corr, William G. Marshall, Matthew J. Dalby and Manuel Salmeron-Sanchez
Engineering nanoscale coatings for ultra-low-dose BMP-2-driven regeneration of critical-size bone defects
published pages: , ISSN: 2095-6231, DOI:
Nature: Bone Research (In review) 2019-06-14

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