Explore the words cloud of the MinBioTag project. It provides you a very rough idea of what is the project "MinBioTag" about.
The following table provides information about the project.
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE
|Coordinator Country||United Kingdom [UK]|
|Total cost||183˙454 €|
|EC max contribution||183˙454 € (100%)|
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
|Duration (year-month-day)||from 2016-04-01 to 2018-03-31|
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|1||THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE||UK (CAMBRIDGE)||coordinator||183˙454.00|
Insight into dynamic processes such as uptake and intracellular trafficking and signalling of small molecules and proteins in cells is key in basic biology and drug development. The use of bioorthogonal chemical reactions for labelling and probing specific biomolecules is an exciting option but a very challenging task as these transformations should proceed very rapidly in physiological conditions with complete chemoselectivity. So, in this application we propose to achieve site-selective protein labelling by the introduction of a non-canonical Cys-cyclobutene aminoacid and a very fast alkene chemoselective ligation reaction. The small size of the proposed alkene-tagged aminoacid should not interfere with the protein structure, function, activity or localisation in contrast with other fluorescent tags such as the use of fusion proteins as GFP. This project aims at 1) developing a new photo triggered  cycloaddition bioorthogonal ligation between two alkene containing partners and to apply the already established IEDDA reaction between tetrazines and dienophiles. While the use of light as a trigger offers the possibility for an improved spatial and temporal resolution, the use of tetrazine fluorogenic probes allows for ‘turn-on’ fluorescence on their rapid reaction with dienophiles 2) use these optimized reaction to study apoptosis in cells and tissues by introducing the proposed Cys-cyclobutene non-canonical amino acid into C2A Domain of Synaptotagmin-I followed by the ligation reaction ex vivo and in vivo
|year||authors and title||journal||last update|
Annabel Kitowski, Ester JimÃ©nez-Moreno, MÃriam SalvadÃ³, Jordi Mestre, Sergio CastillÃ³n, Gonzalo JimÃ©nez-OsÃ©s, Omar Boutureira, GonÃ§alo J. L. Bernardes
Oxidative Activation of Câ€“S Bonds with an Electropositive Nitrogen Promoter Enables Orthogonal Glycosylation of Alkyl over Phenyl Thioglycosides
published pages: 5490-5493, ISSN: 1523-7060, DOI: 10.1021/acs.orglett.7b02886
|Organic Letters 19/19||2019-06-13|
Ester JimÃ©nez-Moreno, Zijian Guo, Bruno L. Oliveira, InÃªs S. Albuquerque, Annabel Kitowski, Ana Guerreiro, Omar Boutureira, Tiago Rodrigues, Gonzalo JimÃ©nez-OsÃ©s, GonÃ§alo J. L. Bernardes
Vinyl Ether/Tetrazine Pair for the Traceless Release of Alcohols in Cells
published pages: 243-247, ISSN: 1433-7851, DOI: 10.1002/anie.201609607
|Angewandte Chemie International Edition 56/1||2019-06-13|
Bernadette Lee, Shuang Sun, Ester JimÃ©nez-Moreno, AndrÃ© A. Neves, GonÃ§alo J.L. Bernardes
Site-selective installation of an electrophilic handle on proteins for bioconjugation
published pages: , ISSN: 0968-0896, DOI: 10.1016/j.bmc.2018.02.028
|Bioorganic & Medicinal Chemistry||2019-06-13|
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The information about "MINBIOTAG" are provided by the European Opendata Portal: CORDIS opendata.