EU H2020 Project "NANOOXYSENS (Luminescent Polymer Nanoparticles with Aza-BODIPYs, Porphyrins and their..)": description, partecipants, costs and EC-fundings

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NanoOxySens project word cloud

Explore the words cloud of the NanoOxySens project. It provides you a very rough idea of what is the project "NanoOxySens" about.

researcher investigation nanoparticles fellowship multidisciplinary organic chemistry excited provides porphyrins internationally fluorescent validated dual conviction obtain 3o2 ratiometric bright photophysics infrared brings molecular characterization metal outstanding mechanism india highest phosphorescent tuning discovered cell cells excellence ultra synthesis absorbing nano biophotonics dyes emission sensitizer emissive sensitizers possibilities nanoprobes bioimaging corresponding interdisciplinary laboratory near transfer innovative polymeric training oxygen scientist device nps photophysical phosphorescence fret encapsulating enormous red record colour bearing sensitive materials acceptor solutions nanoparticle france animals bodipy living publication triplet ing nanosciences phosphoresce designing formulation complexes polymer probes biodegradable excite energy photosensitizers excellent photobiology bodipys fluorescence aza host expertise quality

Project "NanoOxySens" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITE DE STRASBOURG Organization address address: RUE BLAISE PASCAL 4 city: STRASBOURG postcode: 67081 website: http://www.unistra.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	France [FR]
Project website	http://klymchenko-lab.u-strasbg.fr/
Total cost	185˙076 €
EC max contribution	185˙076 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2015
Funding Scheme	MSCA-IF-EF-ST
Starting year	2017
Duration (year-month-day)	from 2017-05-15 to 2019-05-14

#	participants	country	role	EC contrib. [€]
1	UNIVERSITE DE STRASBOURG	FR (STRASBOURG)	coordinator	185˙076.00

UNIVERSITE DE STRASBOURG

FR (STRASBOURG)

coordinator

185˙076.00

Project objective

This proposed Fellowship brings together an Experienced Researcher from India with expertise in the synthesis of photosensitizers and their photophysical characterization, tuning the excited-state properties, investigation of their photophysics and photobiology with an internationally recognized Host Laboratory in France with expertise in designing fluorescent molecular and nanoparticle probes for bioimaging. This project will provide (i) interdisciplinary training of highest quality to become an outstanding scientist with excellent publication record; (ii) enhance European excellence in organic synthesis, nanosciences and biophotonics. The aim of the research project is to obtain ratiometric probes for molecular oxygen based on biodegradable polymeric nanoparticles (NPs) bearing far-red/near-infrared absorbing triplet sensitizers such as aza-BODIPYs, porphyrins and corresponding metal complexes. The project involves the synthesis of phosphorescent dyes (aza-BODIPY/porphyrins) and formulation of polymeric NPs encapsulating these dyes. The development of ultra-bright polymer nanoparticles, an innovative method recently discovered in the Host Laboratory, will enable the development of novel dual emissive polymeric NPs with the triplet sensitizers. In our design, fluorescent NPs excite triplet sensitizers through energy transfer (FRET), resulting in dual emission: fluorescence of NPs and phosphoresce of the sensitizer. Only phosphorescence of FRET acceptor is sensitive to molecular oxygen (3O2), which provides the mechanism of dual colour ratiometric response to oxygen. The approach will be further validated in solutions and in living cells. The obtained nanoprobes for oxygen will be applied to living cell and (in collaboration) to whole animals. It is our strong conviction that the possibilities of this multidisciplinary chemistry are enormous, and the end result will be the development of a simple nano-device for molecular oxygen build from biodegradable materials.

Publications

List of publications.
year	authors and title	journal	last update
2019	Andrey S Klymchenko, Nagappanpillai Adarsh Ionic Aggregation-Induced Emission Dye with Bulky Counterions for Preparation of Bright Near-Infrared Polymeric Nanoparticles published pages: -, ISSN: 2040-3364, DOI: 10.1039/c9nr04085d	Nanoscale 48	2019-09-25

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