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NanoOxySens

Luminescent Polymer Nanoparticles with Aza-BODIPYs, Porphyrins and their Metal Complexes for FRET Mediated Ratiometric Oxygen Sensing

Total Cost €

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EC-Contrib. €

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Partnership

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 NanoOxySens project word cloud

Explore the words cloud of the NanoOxySens project. It provides you a very rough idea of what is the project "NanoOxySens" about.

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Project "NanoOxySens" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE DE STRASBOURG 

Organization address
address: RUE BLAISE PASCAL 4
city: STRASBOURG
postcode: 67081
website: http://www.unistra.fr

contact info
title: n.a.
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surname: n.a.
function: n.a.
email: n.a.
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 Coordinator Country France [FR]
 Project website http://klymchenko-lab.u-strasbg.fr/
 Total cost 185˙076 €
 EC max contribution 185˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-05-15   to  2019-05-14

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE DE STRASBOURG FR (STRASBOURG) coordinator 185˙076.00

Map

 Project objective

This proposed Fellowship brings together an Experienced Researcher from India with expertise in the synthesis of photosensitizers and their photophysical characterization, tuning the excited-state properties, investigation of their photophysics and photobiology with an internationally recognized Host Laboratory in France with expertise in designing fluorescent molecular and nanoparticle probes for bioimaging. This project will provide (i) interdisciplinary training of highest quality to become an outstanding scientist with excellent publication record; (ii) enhance European excellence in organic synthesis, nanosciences and biophotonics. The aim of the research project is to obtain ratiometric probes for molecular oxygen based on biodegradable polymeric nanoparticles (NPs) bearing far-red/near-infrared absorbing triplet sensitizers such as aza-BODIPYs, porphyrins and corresponding metal complexes. The project involves the synthesis of phosphorescent dyes (aza-BODIPY/porphyrins) and formulation of polymeric NPs encapsulating these dyes. The development of ultra-bright polymer nanoparticles, an innovative method recently discovered in the Host Laboratory, will enable the development of novel dual emissive polymeric NPs with the triplet sensitizers. In our design, fluorescent NPs excite triplet sensitizers through energy transfer (FRET), resulting in dual emission: fluorescence of NPs and phosphoresce of the sensitizer. Only phosphorescence of FRET acceptor is sensitive to molecular oxygen (3O2), which provides the mechanism of dual colour ratiometric response to oxygen. The approach will be further validated in solutions and in living cells. The obtained nanoprobes for oxygen will be applied to living cell and (in collaboration) to whole animals. It is our strong conviction that the possibilities of this multidisciplinary chemistry are enormous, and the end result will be the development of a simple nano-device for molecular oxygen build from biodegradable materials.

 Publications

year authors and title journal last update
List of publications.
2019 Andrey S Klymchenko, Nagappanpillai Adarsh
Ionic Aggregation-Induced Emission Dye with Bulky Counterions for Preparation of Bright Near-Infrared Polymeric Nanoparticles
published pages: -, ISSN: 2040-3364, DOI: 10.1039/c9nr04085d
Nanoscale 48 2019-09-25

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