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MID

Molecular Information Dynamics

Total Cost €

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EC-Contrib. €

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Partnership

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Project "MID" data sheet

The following table provides information about the project.

Coordinator
THE HEBREW UNIVERSITY OF JERUSALEM 

Organization address
address: EDMOND J SAFRA CAMPUS GIVAT RAM
city: JERUSALEM
postcode: 91904
website: www.huji.ac.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 182˙509 €
 EC max contribution 182˙509 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-05-01   to  2018-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE HEBREW UNIVERSITY OF JERUSALEM IL (JERUSALEM) coordinator 182˙509.00

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 Project objective

MID will develop and apply a theoretical approach based on information theory to provide a novel representation of the dynamics of single biomolecules and their response to chemical and mechanical stimuli. By integrating the information-theoretic methodology with computational modelling we will elucidate how information is encoded and transduced at the molecular level, with special reference to specific conformational transitions assisting molecular recognition and folding/unfolding dynamics in DNA-ligand complexes. An information-theoretic approach known as surprisal analysis has been initiated for the analysis of selective energy requirements and specific energy disposal of chemical reactions in gas-phase. In this approach, thermodynamic-like state variables are identified from experimental or from simulation data. Following on many other applications in chemistry and physics it has been recently used for the analysis of high throughput biological signalling data. In this proposal, I will advance an analogous framework to treat the dynamics of individual biomolecules. The main outcome will be a compact representation of the dynamics that can handle anharmonic motions, transitions between local minima and long relaxation times. The power of the methodology lies in the development of a thermodynamically consistent theoretical machinery that is applicable at the level of individual molecules and that does not require assumptions about equilibrium. The formalism will be applied in the analysis of molecular dynamics modelling, which will in turn provide mechanistic insights into the dynamics of specific DNA-ligand complexes. The successful implementation of the project relies on the synergy between the expertise of the researcher on theoretical modelling of molecular systems and the expertise of the host Professor who pioneered surprisal analysis and maximum entropy approach for the analysis of chemical reactions and high throughput biological data.

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