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GLYCOSENSE TERMINATED

Polymer brush sensing arrays for the identification of pathogens

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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Project "GLYCOSENSE" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF YORK 

Organization address
address: HESLINGTON
city: YORK NORTH YORKSHIRE
postcode: YO10 5DD
website: http://www.york.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 258˙107 €
 EC max contribution 258˙107 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-GF
 Starting year 2017
 Duration (year-month-day) from 2017-02-01   to  2020-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF YORK UK (YORK NORTH YORKSHIRE) coordinator 258˙107.00
2    THE UNIVERSITY OF SYDNEY AU (SYDNEY) partner 0.00

Map

 Project objective

Surfaces with the capacity for selective recognition of particular pathogens would offer great potential in a number of biomedical applications, including diagnostic devices. Mammalian cells are decorated with a carbohydrate-rich layer, the glycocalyx, which facilitates cellular recognition. Carbohydrate-binding proteins can interact with these sugar motifs to facilitate highly selective recognition, a strategy which is exploited by many viral and bacterial pathogens. Such species have evolved to display recognition units on their surfaces which may interact with considerable affinity with glycan structures displayed on cellular surfaces. This molecular recognition constitutes a key step in the processes of infection or toxicity, and is therefore an attractive target for the development of diagnostic devices. In this project, Dr Clare Mahon proposes to develop surface-tethered polymer brushes which will mimic the glycocalyx in terms of facilitating adhesion of pathogens. Through the incorporation of different fluorophores, the surfaces will be used to construct sensing arrays which will enable the rapid and cost-effective identification of water-borne pathogens and common respiratory pathogens.

 Publications

year authors and title journal last update
List of publications.
2018 Théophile Pelras, Clare S. Mahon, Nonappa, Olli Ikkala, André H. Gröschel, Markus Müllner
Polymer Nanowires with Highly Precise Internal Morphology and Topography
published pages: 12736-12740, ISSN: 0002-7863, DOI: 10.1021/jacs.8b08870
Journal of the American Chemical Society 140/40 2020-04-14
2018 Théophile Pelras, Clare S. Mahon, Markus Müllner
Synthesis and Applications of Compartmentalised Molecular Polymer Brushes
published pages: 6982-6994, ISSN: 1433-7851, DOI: 10.1002/anie.201711878
Angewandte Chemie International Edition 57/24 2020-04-14

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