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GLYCOSENSE TERMINATED

Polymer brush sensing arrays for the identification of pathogens

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

GLYCOSENSE project word cloud

Explore the words cloud of the GLYCOSENSE project. It provides you a very rough idea of what is the project "GLYCOSENSE" about.

considerable decorated facilitates diagnostic construct surfaces cellular motifs glycocalyx rapid viral pathogens toxicity molecular exploited units clare sensing capacity attractive borne displayed layer polymer incorporation infection carbohydrate surface proposes species respiratory dr cells mahon display adhesion selective strategy constitutes mammalian mimic interact structures sugar identification recognition fluorophores bacterial affinity biomedical brushes water arrays proteins binding tethered glycan

Project "GLYCOSENSE" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITY OF YORK Organization address address: HESLINGTON city: YORK NORTH YORKSHIRE postcode: YO10 5DD website: http://www.york.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Total cost	258˙107 €
EC max contribution	258˙107 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2015
Funding Scheme	MSCA-IF-GF
Starting year	2017
Duration (year-month-day)	from 2017-02-01 to 2020-01-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITY OF YORK UNIVERSITY OF YORK Organization address address: HESLINGTON city: YORK NORTH YORKSHIRE postcode: YO10 5DD website: http://www.york.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (YORK NORTH YORKSHIRE)	coordinator	258˙107.00
2	THE UNIVERSITY OF SYDNEY THE UNIVERSITY OF SYDNEY Organization address address: The University of Sydney city: SYDNEY postcode: 2006 website: www.usyd.edu.au/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AU (SYDNEY)	partner	0.00

Map

Project objective

Surfaces with the capacity for selective recognition of particular pathogens would offer great potential in a number of biomedical applications, including diagnostic devices. Mammalian cells are decorated with a carbohydrate-rich layer, the glycocalyx, which facilitates cellular recognition. Carbohydrate-binding proteins can interact with these sugar motifs to facilitate highly selective recognition, a strategy which is exploited by many viral and bacterial pathogens. Such species have evolved to display recognition units on their surfaces which may interact with considerable affinity with glycan structures displayed on cellular surfaces. This molecular recognition constitutes a key step in the processes of infection or toxicity, and is therefore an attractive target for the development of diagnostic devices. In this project, Dr Clare Mahon proposes to develop surface-tethered polymer brushes which will mimic the glycocalyx in terms of facilitating adhesion of pathogens. Through the incorporation of different fluorophores, the surfaces will be used to construct sensing arrays which will enable the rapid and cost-effective identification of water-borne pathogens and common respiratory pathogens.

Publications

List of publications.
year	authors and title	journal	last update
2018	ThÃ©ophile Pelras, Clare S. Mahon, Nonappa, Olli Ikkala, AndrÃ© H. GrÃ¶schel, Markus MÃ¼llner Polymer Nanowires with Highly Precise Internal Morphology and Topography published pages: 12736-12740, ISSN: 0002-7863, DOI: 10.1021/jacs.8b08870	Journal of the American Chemical Society 140/40	2020-04-14
2018	ThÃ©ophile Pelras, Clare S. Mahon, Markus MÃ¼llner Synthesis and Applications of Compartmentalised Molecular Polymer Brushes published pages: 6982-6994, ISSN: 1433-7851, DOI: 10.1002/anie.201711878	Angewandte Chemie International Edition 57/24	2020-04-14

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