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MacMeninges SIGNED

Control of Central Nervous Sytem inflammation by meningeal macrophages, and its impairment upon aging

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 MacMeninges project word cloud

Explore the words cloud of the MacMeninges project. It provides you a very rough idea of what is the project "MacMeninges" about.

myeloid    expertise    fatal    macrophages    solutions    line    vasculature    pathogens    cytometry    intravital    neurodegeneration    prevent    orchestrate    heterogeneity    blood    organ    juxtaposed    overarching    transcranial    differential    initiating    borders    influence    restore    aging    brain    excellence    cns    imaging    cell    histo    strategies    vital    parenchyma    cells    intend    found    ideally    membranes    central    network    natural    profoundly    mice    mount    flow    avenues    inflammatory    protect    nervous    detect    age    induction    drug    positioned    localized    drive    neuroinflammation    meningeal    searching    tools    host    recruitment    resident    accomplished    manipulated    goals    societal    subpopulations    surface    harbor    immune    vast    nature    microbial    understand    activation    inflammation    combinatorial    spread    contribution    meninges    steady    transcriptomics    sharing    impairs    enveloped    immunity    treatment    skills    transgenic   

Project "MacMeninges" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 184˙707 €
 EC max contribution 184˙707 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2019
 Duration (year-month-day) from 2019-05-01   to  2021-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 184˙707.00

Map

 Project objective

Immune responses within the central nervous system (CNS) can drive fatal neuroinflammation and age-related neurodegeneration as seen in the EU but are also crucial to prevent microbial spread into the CNS. It is thus important to understand and control the parameters involved in CNS inflammation. Most studies have focused on the contribution of immune cells localized within the CNS parenchyma. While searching for novel strategies to control neuroinflammation, we and others have found that the nature and activation state of immune cells at the brain surface can profoundly influence CNS inflammation. The parenchyma is enveloped by membranes referred to as the meninges that harbor a vast network of macrophages juxtaposed to blood vasculature, thus ideally positioned to detect pathogens and orchestrate immune cell recruitment into the CNS. The overarching goal of this project is to understand the role of resident meningeal macrophages in initiating and controlling CNS inflammation. To this end, I intend to study the heterogeneity of myeloid subpopulations at steady-state and their differential ability to mount an immune response following a microbial challenge. Furthermore, I will define how natural inflammatory aging impairs the induction of CNS immune responses by meningeal macrophages, and will propose strategies to restore CNS immunity at the brain borders to protect this vital organ. This will be accomplished using combinatorial approaches, including transcriptomics, flow cytometry, histo-cytometry and intravital imaging. Macrophages will be manipulated using transcranial drug delivery and transgenic mice. Sharing skills, expertise, and tools with my host institution will be a key component of this project. Understanding meningeal immunity will open avenues for the treatment of CNS inflammation and neurodegeneration, in line with the H2020 goals of promoting research excellence in the EU to deliver solutions to important societal challenges.

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The information about "MACMENINGES" are provided by the European Opendata Portal: CORDIS opendata.

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