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SiCMetabol SIGNED

Signaling Cascades in Metabolic Diseases

Total Cost €

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EC-Contrib. €

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Partnership

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 SiCMetabol project word cloud

Explore the words cloud of the SiCMetabol project. It provides you a very rough idea of what is the project "SiCMetabol" about.

regulating    lipids    million    defective    rates    relative    course    leads    controls    modules    worldwide    phosphorylation    pkd1    insulin    strategies    over    caused    secretion    hyperglycemia    pkd2    phosphatases    characterizing    regulation    signaling    380    hepatic    localization    lipogenesis    glucose    combination    treatment    pkds    kinases    central    perturbations    liver    mechanisms    dysfunction    shown    classes    implicated    metabolic    t2d    organs    suggest    cascades    decreased    regulators    levels    parallel    obesity    adipose    attenuate    people    components    canonical    risk    adipokines    hyperlipidemia    homeostasis    deficiency    determines    metabolism    poorly    ubiquitin    networks    attributed    resistance    diabetes    hypothesize    lipolysis    abundance    function    screening    gluconeogenesis    suffer    family    disease    utilize    pkd    pkd3    molecular    plan    peripheral    cross    majority    normalization    pharmacological    tissue    talk    predisposing    laboratory    molecules    roles   

Project "SiCMetabol" data sheet

The following table provides information about the project.

Coordinator
JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG 

Organization address
address: SANDERRING 2
city: WUERZBURG
postcode: 97070
website: http://www.uni-wuerzburg.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website https://www.uni-wuerzburg.de/en/rvz/research/research-groups/sumara-group/
 Total cost 1˙499˙128 €
 EC max contribution 1˙499˙128 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-STG
 Funding Scheme ERC-STG
 Starting year 2016
 Duration (year-month-day) from 2016-06-01   to  2021-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG DE (WUERZBURG) coordinator 1˙499˙128.00

Map

 Project objective

Over 380 million people suffer from diabetes worldwide, with majority of cases being attributed to type 2 diabetes (T2D). Obesity is a major risk factor predisposing to the development of this disease. T2D is characterized by peripheral insulin resistance in combination with relative insulin deficiency that results in hyperglycemia and hyperlipidemia. Liver and adipose tissue are central for regulation of glucose and lipids levels. However, during T2D the hepatic glucose uptake is reduced while rates of gluconeogenesis and lipogenesis are increased. In the adipose tissue, T2D leads to decreased glucose uptake, perturbations in secretion of adipokines and increased lipolysis. Importantly, dysfunction of the liver and the adipose tissue during T2D is caused by defective phosphorylation signaling cascades and normalization of these pathways was shown to attenuate the course of T2D. However, the specific roles of different classes of signaling molecules in these organs remain poorly characterized. We hypothesize that the cross-talk of different classes of signaling molecules determines regulation of metabolism. Thus, we aim to identify the signaling networks regulating metabolism. The results generated in my own laboratory suggest that the Pkd family kinases are the crucial regulators of metabolic homeostasis. Specifically, Pkd1 and Pkd2 promote obesity and diabetes while Pkd3 controls liver function. Thus, we plan to characterize the molecular mechanisms controlling Pkds signaling. In parallel, we will utilize screening approaches to identify novel, non-canonical signaling modules (phosphatases and components of the ubiquitin system) regulating abundance, localization and phosphorylation of targets of Pkds and, in the long term, also other kinases implicated in T2D. By identifying and characterizing the essential signaling networks in liver and adipose tissue the project will contribute to more targeted pharmacological strategies for the treatment of T2D.

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The information about "SICMETABOL" are provided by the European Opendata Portal: CORDIS opendata.

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