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SiCMetabol SIGNED

Signaling Cascades in Metabolic Diseases

Total Cost €

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EC-Contrib. €

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Partnership

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 SiCMetabol project word cloud

Explore the words cloud of the SiCMetabol project. It provides you a very rough idea of what is the project "SiCMetabol" about.

regulators    function    dysfunction    controls    signaling    disease    modules    perturbations    t2d    deficiency    shown    pharmacological    pkd2    organs    talk    homeostasis    liver    normalization    decreased    utilize    attenuate    implicated    phosphorylation    plan    attributed    pkds    cross    caused    networks    relative    tissue    defective    levels    roles    molecules    hyperlipidemia    kinases    screening    glucose    regulation    people    canonical    peripheral    adipokines    leads    cascades    pkd1    characterizing    hepatic    rates    lipolysis    course    resistance    combination    family    abundance    hyperglycemia    predisposing    majority    over    lipids    metabolism    secretion    million    strategies    obesity    pkd    determines    central    mechanisms    components    380    metabolic    parallel    diabetes    regulating    laboratory    localization    phosphatases    ubiquitin    insulin    adipose    molecular    poorly    pkd3    treatment    lipogenesis    suffer    worldwide    classes    hypothesize    gluconeogenesis    risk    suggest   

Project "SiCMetabol" data sheet

The following table provides information about the project.

Coordinator
JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG 

Organization address
address: SANDERRING 2
city: WUERZBURG
postcode: 97070
website: http://www.uni-wuerzburg.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website https://www.uni-wuerzburg.de/en/rvz/research/research-groups/sumara-group/
 Total cost 1˙499˙128 €
 EC max contribution 1˙499˙128 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-STG
 Funding Scheme ERC-STG
 Starting year 2016
 Duration (year-month-day) from 2016-06-01   to  2021-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG DE (WUERZBURG) coordinator 1˙499˙128.00

Map

 Project objective

Over 380 million people suffer from diabetes worldwide, with majority of cases being attributed to type 2 diabetes (T2D). Obesity is a major risk factor predisposing to the development of this disease. T2D is characterized by peripheral insulin resistance in combination with relative insulin deficiency that results in hyperglycemia and hyperlipidemia. Liver and adipose tissue are central for regulation of glucose and lipids levels. However, during T2D the hepatic glucose uptake is reduced while rates of gluconeogenesis and lipogenesis are increased. In the adipose tissue, T2D leads to decreased glucose uptake, perturbations in secretion of adipokines and increased lipolysis. Importantly, dysfunction of the liver and the adipose tissue during T2D is caused by defective phosphorylation signaling cascades and normalization of these pathways was shown to attenuate the course of T2D. However, the specific roles of different classes of signaling molecules in these organs remain poorly characterized. We hypothesize that the cross-talk of different classes of signaling molecules determines regulation of metabolism. Thus, we aim to identify the signaling networks regulating metabolism. The results generated in my own laboratory suggest that the Pkd family kinases are the crucial regulators of metabolic homeostasis. Specifically, Pkd1 and Pkd2 promote obesity and diabetes while Pkd3 controls liver function. Thus, we plan to characterize the molecular mechanisms controlling Pkds signaling. In parallel, we will utilize screening approaches to identify novel, non-canonical signaling modules (phosphatases and components of the ubiquitin system) regulating abundance, localization and phosphorylation of targets of Pkds and, in the long term, also other kinases implicated in T2D. By identifying and characterizing the essential signaling networks in liver and adipose tissue the project will contribute to more targeted pharmacological strategies for the treatment of T2D.

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The information about "SICMETABOL" are provided by the European Opendata Portal: CORDIS opendata.

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