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SiCMetabol SIGNED

Signaling Cascades in Metabolic Diseases

Total Cost €

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EC-Contrib. €

0

Partnership

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 SiCMetabol project word cloud

Explore the words cloud of the SiCMetabol project. It provides you a very rough idea of what is the project "SiCMetabol" about.

strategies    lipogenesis    people    function    obesity    roles    molecular    molecules    regulators    levels    diabetes    deficiency    metabolic    organs    screening    canonical    implicated    380    t2d    homeostasis    gluconeogenesis    family    dysfunction    signaling    majority    perturbations    hyperlipidemia    modules    risk    determines    disease    suffer    pharmacological    components    parallel    suggest    defective    talk    lipids    regulation    poorly    decreased    pkd3    adipose    treatment    tissue    controls    leads    lipolysis    mechanisms    phosphatases    worldwide    plan    localization    resistance    attenuate    normalization    ubiquitin    central    pkds    utilize    adipokines    secretion    over    regulating    hepatic    characterizing    pkd2    rates    metabolism    classes    pkd    million    abundance    cascades    shown    insulin    phosphorylation    course    glucose    kinases    cross    predisposing    peripheral    liver    caused    networks    hyperglycemia    attributed    combination    relative    hypothesize    laboratory    pkd1   

Project "SiCMetabol" data sheet

The following table provides information about the project.

Coordinator
JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG 

Organization address
address: SANDERRING 2
city: WUERZBURG
postcode: 97070
website: http://www.uni-wuerzburg.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website https://www.uni-wuerzburg.de/en/rvz/research/research-groups/sumara-group/
 Total cost 1˙499˙128 €
 EC max contribution 1˙499˙128 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-STG
 Funding Scheme ERC-STG
 Starting year 2016
 Duration (year-month-day) from 2016-06-01   to  2021-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG DE (WUERZBURG) coordinator 1˙499˙128.00

Map

 Project objective

Over 380 million people suffer from diabetes worldwide, with majority of cases being attributed to type 2 diabetes (T2D). Obesity is a major risk factor predisposing to the development of this disease. T2D is characterized by peripheral insulin resistance in combination with relative insulin deficiency that results in hyperglycemia and hyperlipidemia. Liver and adipose tissue are central for regulation of glucose and lipids levels. However, during T2D the hepatic glucose uptake is reduced while rates of gluconeogenesis and lipogenesis are increased. In the adipose tissue, T2D leads to decreased glucose uptake, perturbations in secretion of adipokines and increased lipolysis. Importantly, dysfunction of the liver and the adipose tissue during T2D is caused by defective phosphorylation signaling cascades and normalization of these pathways was shown to attenuate the course of T2D. However, the specific roles of different classes of signaling molecules in these organs remain poorly characterized. We hypothesize that the cross-talk of different classes of signaling molecules determines regulation of metabolism. Thus, we aim to identify the signaling networks regulating metabolism. The results generated in my own laboratory suggest that the Pkd family kinases are the crucial regulators of metabolic homeostasis. Specifically, Pkd1 and Pkd2 promote obesity and diabetes while Pkd3 controls liver function. Thus, we plan to characterize the molecular mechanisms controlling Pkds signaling. In parallel, we will utilize screening approaches to identify novel, non-canonical signaling modules (phosphatases and components of the ubiquitin system) regulating abundance, localization and phosphorylation of targets of Pkds and, in the long term, also other kinases implicated in T2D. By identifying and characterizing the essential signaling networks in liver and adipose tissue the project will contribute to more targeted pharmacological strategies for the treatment of T2D.

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The information about "SICMETABOL" are provided by the European Opendata Portal: CORDIS opendata.

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