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SUPRABIOTICS SIGNED

Supramolecular Protective Groups Enabling Antibiotics and Bioimaging

Total Cost €

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EC-Contrib. €

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Partnership

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 SUPRABIOTICS project word cloud

Explore the words cloud of the SUPRABIOTICS project. It provides you a very rough idea of what is the project "SUPRABIOTICS" about.

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Project "SUPRABIOTICS" data sheet

The following table provides information about the project.

Coordinator
RIJKSUNIVERSITEIT GRONINGEN 

Organization address
address: Broerstraat 5
city: GRONINGEN
postcode: 9712CP
website: www.rug.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 2˙500˙000 €
 EC max contribution 2˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-AdG
 Funding Scheme ERC-ADG
 Starting year 2016
 Duration (year-month-day) from 2016-09-01   to  2021-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    RIJKSUNIVERSITEIT GRONINGEN NL (GRONINGEN) coordinator 2˙500˙000.00

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 Project objective

The pharmaceutical sector has a huge demand for new active compounds including natural products to fill the drug pipelines and to stop the global decline in novel approved active pharmaceutical ingredients. Therefore, developing new tools to fabricate complex molecular structures in a fast and reliable way is paramount. This holds especially true for the field of antibiotics. Multidrug resistant (MDR) pathogens evolve at a terrifying rate and confer resistance to all presently available antibacterial treatments and therefore WHO has identified MDR bacteria as major threat to human health.

In this ERC Advanced Grant, I propose a radically new approach to fabricate very complex molecules with minimal synthetic effort. The technology is based on nucleic acid binders (aptamers), which are evolved in a selection protocol and block several functional groups within a target molecule while allowing other functionalities not in contact with the aptamer to be selectively modified in a single reaction step. Here, we aim to establish this groundbreaking aptameric protective group (APG) method as a novel tool that gives access to compounds that would otherwise be too difficult to obtain by multistep synthesis. Toward this end, the specific objectives are:

• To develop reagents and reactions that are compatible with aptamer-mediated reactions • To control the site of chemical modification within complex molecules by APGs • To establish APGs as a general paradigm in natural product derivatization to modify several kinds of substrates • To achieve site selective modification of proteins by aptamers • To synthesize novel antibiotics that kill MDR bacteria • To fabricate “image-and-activate” antibiotics by the APG technology • To employ the aptamer-target complexes for live-cell imaging of RNA

The outcomes will enable future advances in drug discovery and drug design, bioimaging technologies, and the site-specific modification of therapeutic proteins.

 Publications

year authors and title journal last update
List of publications.
2017 Lei Zhang, Lifei Zheng, Zhuojun Meng, Konstantin Balinin, Mark Loznik, Andreas Herrmann
Accelerating chemical reactions by molecular sledding
published pages: 6331-6334, ISSN: 1359-7345, DOI: 10.1039/C7CC02500A
Chemical Communications 53/47 2019-06-13
2017 Kai Liu, Chao Ma, Robert Göstl, Lei Zhang, Andreas Herrmann
Liquefaction of Biopolymers: Solvent-free Liquids and Liquid Crystals from Nucleic Acids and Proteins
published pages: 1212-1221, ISSN: 0001-4842, DOI: 10.1021/acs.accounts.7b00030
Accounts of Chemical Research 50/5 2019-06-13
2017 Lei Zhang, Sourav Maity, Kai Liu, Qing Liu, Robert Göstl, Giuseppe Portale, Wouter H. Roos, Andreas Herrmann
Nematic DNA Thermotropic Liquid Crystals with Photoresponsive Mechanical Properties
published pages: 1701207, ISSN: 1613-6810, DOI: 10.1002/smll.201701207
Small 13/34 2019-06-13
2017 Kai Liu, Lifei Zheng, Chao Ma, Robert Göstl, Andreas Herrmann
DNA–surfactant complexes: self-assembly properties and applications
published pages: 5147-5172, ISSN: 0306-0012, DOI: 10.1039/C7CS00165G
Chemical Society Reviews 46/16 2019-06-13
2018 Anouk S. Lubbe, Qing Liu, Sanne J. Smith, Jan Willem de Vries, Jos C. M. Kistemaker, Alex H. de Vries, Ignacio Faustino, Zhuojun Meng, Wiktor Szymanski, Andreas Herrmann, Ben L. Feringa
Photoswitching of DNA Hybridization Using a Molecular Motor
published pages: 5069-5076, ISSN: 0002-7863, DOI: 10.1021/jacs.7b09476
Journal of the American Chemical Society 140(15) 2019-06-13
2018 Alessio Marcozzi, Tiziana Masini, Di Zhu, Diego Pesce, Boris Illarionov, Markus Fischer, Andreas Herrmann, Anna K. H. Hirsch
Phage Display on the Anti-infective Target 1-Deoxy- d -xylulose-5-phosphate Synthase Leads to an Acceptor-Substrate Competitive Peptidic Inhibitor
published pages: 58-65, ISSN: 1439-4227, DOI: 10.1002/cbic.201700402
ChemBioChem 19/1 2019-06-13
2019 Shuaidong Huo, Hongyan Li, Arnold J. Boersma, Andreas Herrmann
DNA Nanotechnology Enters Cell Membranes
published pages: 1900043, ISSN: 2198-3844, DOI: 10.1002/advs.201900043
Advanced Science 6/10 2019-06-06
2018 Esra te Brinke, Joost Groen, Andreas Herrmann, Hans A. Heus, Germán Rivas, Evan Spruijt, Wilhelm T. S. Huck
Dissipative adaptation in driven self-assembly leading to self-dividing fibrils
published pages: 849-855, ISSN: 1748-3387, DOI: 10.1038/s41565-018-0192-1
Nature Nanotechnology 13/9 2019-06-06
2019 Jochem H. Smit, Jasper H. M. van der Velde, Jingyi Huang, Vanessa Trauschke, Sarah S. Henrikus, Si Chen, Nikolaos Eleftheriadis, Eliza M. Warszawik, Andreas Herrmann, Thorben Cordes
On the impact of competing intra- and intermolecular triplet-state quenching on photobleaching and photoswitching kinetics of organic fluorophores
published pages: 3721-3733, ISSN: 1463-9076, DOI: 10.1039/c8cp05063e
Physical Chemistry Chemical Physics 21/7 2019-06-06
2018 Jian Yang, Zhuojun Meng, Qing Liu, Yasuhito Shimada, René C. L. Olsthoorn, Herman P. Spaink, Andreas Herrmann, Alexander Kros
Performing DNA nanotechnology operations on a zebrafish
published pages: 7271-7276, ISSN: 2041-6520, DOI: 10.1039/c8sc01771a
Chemical Science 9/36 2019-06-06
2018 Lei Zhang, Chao Ma, Jing Sun, Baiqi Shao, Giuseppe Portale, Dong Chen, Kai Liu, Andreas Herrmann
Genetically Engineered Supercharged Polypeptide Fluids: Fast and Persistent Self-Ordering Induced by Touch
published pages: 6878-6882, ISSN: 1433-7851, DOI: 10.1002/anie.201803169
Angewandte Chemie International Edition 57/23 2019-06-06

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