Explore the words cloud of the REGDAM project. It provides you a very rough idea of what is the project "REGDAM" about.
The following table provides information about the project.
FUNDACAO CALOUSTE GULBENKIAN
|Coordinator Country||Portugal [PT]|
|Total cost||148˙635 €|
|EC max contribution||148˙635 € (100%)|
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
|Duration (year-month-day)||from 2017-04-01 to 2019-03-31|
Take a look of project's partnership.
|1||FUNDACAO CALOUSTE GULBENKIAN||PT (LISBOA)||coordinator||148˙635.00|
Regulatory T cells (TREG) are critical players in the control of innate and adaptive immune responses while impacting as well on the functional output of parenchyma tissues. This later effect is exerted by tissue-resident TREG, via an ill-defined mechanism that modulates tissue damage control, that is, a protective response of parenchyma tissues that limits cellular dysfunction and/or damage imposed by inflammation and immunity. The central hypothesis to be tested under this proposal is that tissue-resident TREG modulate tissue damage control via a number of adaptive responses to cellular stress, which preserve the functional outputs of parenchyma tissues. Failure of tissue-resident TREG to modulate adaptive responses to oxidative and hypoxic stress should exacerbate the deleterious effects imposed by these forms of stress on parenchyma cells and as such promote the pathogenesis of immune mediated inflammatory diseases. Under this Marie-Curie fellowship we will address mechanistically how TREG receive signals from tissues exposed to oxidative and hypoxic stress and migrate to those tissues to modulate oxidative and hypoxic stress responses as to dampen tissue damage.
|year||authors and title||journal||last update|
Birte Blankenhaus, Faouzi Braza, Rui Martins, Patricia Bastos-Amador, Ismael GonzÃ¡lez-GarcÃa, Ana Rita Carlos, InÃªs Mahu, Pedro Faisca, Jose Moura Nunes, Pedro Ventura, Verena Hoerr, Sebastian Weis, Joel Guerra, Silvia Cardoso, Ana Domingos, Miguel LÃ³pez, Miguel P. Soares
Ferritin regulates organismal energy balance and thermogenesis
published pages: 64-79, ISSN: 2212-8778, DOI: 10.1016/j.molmet.2019.03.008
|Molecular Metabolism 24||2019-09-17|
Rui Martins, Ana Rita Carlos, Faouzi Braza, Jessica A. Thompson, Patricia Bastos-Amador, Susana Ramos, Miguel P. Soares
Disease Tolerance as an Inherent Component of Immunity
published pages: 405-437, ISSN: 0732-0582, DOI: 10.1146/annurev-immunol-042718-041739
|Annual Review of Immunology 37/1||2019-09-17|
Susana Ramos, Ana Rita Carlos, Balamurugan Sundaram, Viktoria Jeney, Ana Ribeiro, Raffaella Gozzelino, Claudia Bank, Erida Gjini, Faouzi Braza, Rui Martins, Temitope Wilson Ademolue, Birte Blankenhaus, ZÃ©lia Gouveia, Pedro FaÃsca, Damian Trujillo, SÃlvia Cardoso, Sofia Rebelo, Laura del Barrio, Abolfazl Zarjou, Subhashini Bolisetty, Anupam Agarwal, Miguel P. Soares
Renal control of disease tolerance to malaria
published pages: 5681-5686, ISSN: 0027-8424, DOI: 10.1073/pnas.1822024116
|Proceedings of the National Academy of Sciences 116/12||2019-09-17|
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