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SMILED SIGNED

Skeletal Muscle Inflammation: ambivalent roles in Exercise and Diabetes

Total Cost €

0

EC-Contrib. €

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Partnership

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 SMILED project word cloud

Explore the words cloud of the SMILED project. It provides you a very rough idea of what is the project "SMILED" about.

exercise    local    skeletal    promoter    methylation    proof    dna    diet    events    constitutes    genes    t2d    ambivalent    chromatin    multifactorial    translate    occurs    complications    little    human    interaction    inflammatory    obtain    repair    epigenetic    discoveries    diseases    suggested    signal    burden    tissue    unknown    metabolic    cell    parallel    living    homeostasis    people    sedentary    regulations    rnas    effect    environmental    unmanageable    hallmark    million    sensitivity    physical    90    greatest    primary    inflammation    severe    transduction    fact    strategies    economic    52    roles    lifestyle    cardiovascular    profiling    biopsies    highlights    small    adipose    obesity    disease    plays    muscle    dependent    diabetes    metabolism    anti    links    innovative    despite    treatment    potent    intervention    beneficial    leads    insulin    therapeutic    abnormal    interventional    expression    contributor    surprisingly    myopathies    cultures    molecular    induces    structure    glucose    suggesting   

Project "SMILED" data sheet

The following table provides information about the project.

Coordinator
KAROLINSKA INSTITUTET 

Organization address
address: Nobels Vag 5
city: STOCKHOLM
postcode: 17177
website: www.ki.se

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 185˙857 €
 EC max contribution 185˙857 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-05-01   to  2018-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KAROLINSKA INSTITUTET SE (STOCKHOLM) coordinator 185˙857.00

Map

 Project objective

In Europe, 52 million people are living with diabetes, with more than 90% of them having type 2 diabetes (T2D), a multifactorial disease associated with obesity and sedentary lifestyle. It leads to severe complications such as cardiovascular events and constitutes an unmanageable economic burden. Skeletal muscle inflammation is emerging as a potential contributor to T2D. Inflammation occurs during exercise and repair and is a hallmark of myopathies, suggesting that it plays crucial roles in skeletal muscle homeostasis. Despite the fact that exercise is associated with inflammation, physical activity has beneficial effects on T2D, which highlights the ambivalent role of muscle inflammation in controlling glucose homeostasis. Epigenetic processes are potential molecular links between diseases and environmental factors such as diet and exercise. Abnormal promoter methylation of inflammatory genes was recently suggested in adipose tissue during obesity, but little is currently known about epigenetic regulations in muscle during exercise and diabetes. Surprisingly, it is unknown whether there is any parallel between local inflammation of muscle and T2D and no therapeutic strategies currently target skeletal muscle for T2D treatment. The overall aim of this proposal is to determine the interaction between inflammation and the metabolic response to exercise and T2D to define potent interventional strategies that can improve insulin sensitivity. It will identify what type of inflammatory response induces the greatest metabolic effect on signal transduction and expression of genes through profiling DNA methylation, chromatin structure and small RNAs. It will use primary cell cultures from human biopsies to (1) obtain proof of principle that the beneficial effect of exercise on metabolism is dependent on inflammation, and (2) translate these discoveries into innovative exercise and anti-inflammatory intervention strategies to improve insulin sensitivity.

 Publications

year authors and title journal last update
List of publications.
2017 Nicolas J. Pillon, Anna Krook
Innate immune receptors in skeletal muscle metabolism
published pages: 47-54, ISSN: 0014-4827, DOI: 10.1016/j.yexcr.2017.02.035
Experimental Cell Research 360/1 2019-06-13
2018 Evangelia Daskalaki, Nicolas J. Pillon, Anna Krook, Craig E. Wheelock, Antonio Checa
The influence of culture media upon observed cell secretome metabolite profiles: The balance between cell viability and data interpretability
published pages: , ISSN: 0003-2670, DOI: 10.1016/j.aca.2018.04.034
Analytica Chimica Acta 2019-06-13
2018 Nicolas J Pillon, Scott Frendo-Cumbo, Maya R Jacobson, Zhi Liu, Paul L Milligan, Hai Hoang Bui, Juleen R Zierath, Philip J Bilan, Joseph T Brozinick, Amira Klip
Cell-autonomous sphingolipid changes do not underlie fatty acid-induced insulin resistance of GLUT4 translocation or pro-inflammatory signaling in muscle cells
published pages: jlr.M080788, ISSN: 0022-2275, DOI: 10.1194/jlr.M080788
Journal of Lipid Research 2019-06-13
2018 Christophe O. Soulage, Laura Sardón Puig, Laurent Soulère, Bader Zarrouki, Michel Guichardant, Michel Lagarde, Nicolas J. Pillon
Skeletal muscle insulin resistance is induced by 4-hydroxy-2-hexenal, a by-product of n-3 fatty acid peroxidation
published pages: 688-699, ISSN: 0012-186X, DOI: 10.1007/s00125-017-4528-4
Diabetologia 61/3 2019-06-13

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