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CrUCCial SIGNED

Novel diagnostic and therapeutic approach to inflammatory bowel disease based on functional characterization of patients: the CrUCCial index

Total Cost €

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EC-Contrib. €

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Partnership

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 CrUCCial project word cloud

Explore the words cloud of the CrUCCial project. It provides you a very rough idea of what is the project "CrUCCial" about.

individual    molecular    pilot    attempted    individually    genetically    immune    functionally    ibd    chronic    revolutionize    correlation    ulcerative    whom    tailoring    contribution    intestinal    microbiome    multifactorial    outcome    translated    stress    gut    bacterial    diseases    paradigm    remission    angle    onset    immunologic    proportional    therapeutic    reflecting    uc    mucosal    intervention    leaving    clinical    predisposed    diagnosis    ends    components    tested    bowel    margins    diagnosed    autophagy    breakthrough    individuals    trial    50    patient    crohn    construct    agents    epi    never    characterization    inflammatory    therapy    nowadays    treating    mechanisms    prognosis    function    integrity    improvement    metagenomic    index    disease    patients    heterogeneous    endoplasmic    transcriptomic    readouts    outcomes    anti    functional    colitis    newly    cruccial    reticulum    of    genetic    cellular    barrier    pathogenic    cd    emerged    interplay    opposite    recognition    phenotype   

Project "CrUCCial" data sheet

The following table provides information about the project.

Coordinator
KATHOLIEKE UNIVERSITEIT LEUVEN 

Organization address
address: OUDE MARKT 13
city: LEUVEN
postcode: 3000
website: www.kuleuven.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 2˙494˙500 €
 EC max contribution 2˙494˙500 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-AdG
 Funding Scheme ERC-ADG
 Starting year 2016
 Duration (year-month-day) from 2016-09-01   to  2021-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KATHOLIEKE UNIVERSITEIT LEUVEN BE (LEUVEN) coordinator 2˙494˙500.00

Map

 Project objective

The clinical phenotype and the outcome of Crohn's disease (CD) and ulcerative colitis (UC), the opposite ends of chronic inflammatory bowel diseases (IBD), are heterogeneous and represent the result of a complex interplay of the gut microbiome with the immune system in genetically predisposed individuals. Disease management is much less heterogeneous as all patients are treated using non-specific anti-inflammatory agents, and only 30-50% achieve clinical and mucosal remission -the goal of therapy nowadays- therefore leaving large margins for improvement. The advances in knowledge about the factors triggering disease onset should be translated to approach the disease from a molecular angle. Key cellular pathways have emerged including bacterial recognition, autophagy, endoplasmic reticulum stress and intestinal barrier function. Functional/molecular characterization of these pathways in a given patient, correlation with meaningful clinical outcomes, and tailoring an individual therapeutic approach has never been attempted and will represent a breakthrough in the current paradigm of treating multifactorial inflammatory conditions. This project aims to functionally characterize patients with CD/UC for the major pathways by using integrated (epi)genetic, transcriptomic, immunologic, barrier integrity and metagenomic studies. From these readouts we will construct an index [the Crohn’s and Ulcerative Colitis Characterization and Intervention trial (CrUCCial) index], reflecting the proportional contribution of each of the pathogenic mechanisms in a given patient. We will next study the correlation of this index and its components to meaningful clinical outcomes and finally, the index will be tested in a pilot study of newly diagnosed patients in whom the disease will be targeted individually based on the components of the CrUCCial index. Our approach, from diagnosis over prognosis to therapy, will revolutionize the paradigm of disease management.

 Publications

year authors and title journal last update
List of publications.
2017 Maaike Vancamelbeke, Séverine Vermeire
The intestinal barrier: a fundamental role in health and disease
published pages: 821-834, ISSN: 1747-4124, DOI: 10.1080/17474124.2017.1343143
Expert Review of Gastroenterology & Hepatology 11/9 2019-06-13
2017 Maaike Vancamelbeke, Tim Vanuytsel, Ricard Farré, Sare Verstockt, Marc Ferrante, Gert Van Assche, Paul Rutgeerts, Frans Schuit, Séverine Vermeire, Ingrid Arijs, Isabelle Cleynen
Genetic and Transcriptomic Bases of Intestinal Epithelial Barrier Dysfunction in Inflammatory Bowel Disease
published pages: 1718-1729, ISSN: 1078-0998, DOI: 10.1097/MIB.0000000000001246
Inflammatory Bowel Diseases 23/10 2019-06-13
2017 Wiebe Vanhove, Kris Nys, Ingrid Arijs, Isabelle Cleynen, Magali de Bruyn, Hannelie Korf, Marc Ferrante, Gert A. Van Assche, Severine Vermeire
Tu1770 Genetic Defects in ER Stress and Autophagy Translate Into Increased Functional ER Stress Levels in Patients with Inflammatory Bowel Disease
published pages: S963-S964, ISSN: 0016-5085, DOI:
Gastroenterology 152/5 2019-06-13
2017 Kathleen Machiels, Marta Pozuelo del Río, João Sabino, Alba Santiago, David Campos, Albert Wolthuis, Anthony de Buck van Overstraeten, Andre D\'Hoore, Gert A. Van Assche, Marc Ferrante, Paul Rutgeerts, Gert De Hertogh, Severine Vermeire, Chaysavanh Manichanh
Tu1857: Mucosal Recolonization after Ileocecal Resection Differs in Crohn\'s Disease Patients Developing Postoperative Recurrence
published pages: S990, ISSN: 0016-5085, DOI:
Gastroenterology 152/5 2019-06-13
2017 Manuel Noben, Wiebe Vanhove, Kaline Arnauts, Anabela Santo Ramalho, Gert Van Assche, Séverine Vermeire, Catherine Verfaillie, Marc Ferrante
Human intestinal epithelium in a dish: Current models for research into gastrointestinal pathophysiology
published pages: 1073-1081, ISSN: 2050-6406, DOI: 10.1177/2050640617722903
United European Gastroenterology Journal 5/8 2019-06-13
2018 S Verstockt, E Glorieus, M De Decker, B Verstockt, N Ardeshir Davani, V Ballet, G Van Assche, P Hindryckx, M Ferrante, D Laukens, F Mana, M De Vos, S Vermeire, I Cleynen
P117 Serum proteomic analysis characterises newly diagnosed Crohn’s disease and ulcerative colitis depending on the age at diagnosis
published pages: S151-S152, ISSN: 1873-9946, DOI:
Journal of Crohn\'s and Colitis 12/supplement_1 2019-06-13
2018 B Verstockt, S Vermeire, S Verstockt, B Creyns, N Ardeshir Davani, C Breynaert, G Van Assche, G Van Assche, M Ferrante
P035 Serum markers predict outcome to ustekinumab in patients with refractory Crohn’s disease and provide insides in the mechanism of action
published pages: S110-S110, ISSN: 1873-9946, DOI:
Journal of Crohn\'s and Colitis 12/supplement_1 2019-06-13
2018 B Verstockt, S Verstockt, M de Bruyn, K Machiels, H Blevi, V Ballet, G Van Assche, S Vermeire, M Ferrante
P042 Decreased leukocyte trafficking may contribute to vedolizumab refractory disease after anti-TNF exposure in patients with ulcerative colitis
published pages: S113-S113, ISSN: 1873-9946, DOI:
Journal of Crohn\'s and Colitis 12/supplement_1 2019-06-13
2018 M Vancamelbeke, S Verstockt, M Ferrante, G Van Assche, S Vermeire, I Cleynen
P084 Ileal gene expression changes are associated with colonic disease activity in patients with ulcerative colitis
published pages: S134-S136, ISSN: 1873-9946, DOI:
Journal of Crohn\'s and Colitis 12/supplement_1 2019-06-13
2018 K Machiels, M de Bruyn, S Verstockt, B Verstockt, G Van Assche, A Wolthuis, A d\'Hoore, M Ferrante, S Vermeire
P010 Serum proteomic profiling in Crohn’s disease patients undergoing ileocolonic resection reveals discriminative inflammatory markers for endoscopic recurrence
published pages: S096-S097, ISSN: 1873-9946, DOI:
Journal of Crohn\'s and Colitis 12/supplement_1 2019-06-13
2018 C Caenepeel, S Vieira-Silva, J Sabino, K Machiels, G Falony, M Ferrante, G Van Assche, J Raes, S Vermeire
P854 Quantitative microbiome profiling changes the described dysbiotic state in inflammatory bowel disease
published pages: S548-S549, ISSN: 1873-9946, DOI:
Journal of Crohn\'s and Colitis 12/supplement_1 2019-06-13
2017 Maaike Vancamelbeke, João Sabino, Lise Deroover, Greet Vandermeulen, Anja Luypaerts, Marc Ferrante, Gwen Falony, Sara Vieira-Silva, Kristin Verbeke, Jeroen Raes, Isabelle Cleynen, Severine Vermeire
Tu1862 Profiling of the Fecal Microbiota and Metabolome in Patients with Inflammatory Bowel Disease and their Unaffected Relatives
published pages: S991, ISSN: 0016-5085, DOI:
Gastroenterology 152/5 2019-06-13
2017 Kathleen Machiels, Victoria Pascal, João Sabino, Alba Santiago, David Campos, Albert Wolthuis, Anthony de Buck van Overstraeten, Andre D\'Hoore, Gert A. Van Assche, Marc Ferrante, Paul Rutgeerts, Chaysavanh Manichanh, Severine Vermeire
Tu1856: Impact of Ileocecal Resection in Crohn\'s Disease Patients on Fecal Microbiota
published pages: S989-S990, ISSN: 0016-5085, DOI:
Gastroenterology 152/5 2019-06-13
2018 M Vancamelbeke, V Ballet, N Ardeshir Davani, G Van Assche, M Ferrante, I Cleynen, S Vermeire
P052 Protein biomarkers identify subclinical inflammation patterns in first-degree relatives of patients with inflammatory bowel disease
published pages: S118-S119, ISSN: 1873-9946, DOI:
Journal of Crohn\'s and Colitis 12/supplement_1 2019-06-13
2018 S Verstockt, B Verstockt, J Van Bouwel, W Meert, A Cortes Calabuig, V Brys, V Ballet, E Glorieus, M De Decker, G Van Assche, P Hindryckx, M Ferrante, D Laukens, F Mana, M De Vos, S Vermeire, I Cleynen
P104 Gene expression profiles in inflamed colonic biopsies from newly diagnosed Crohn’s disease and ulcerative colitis patients differ depending on the age at diagnosis
published pages: S146-S146, ISSN: 1873-9946, DOI:
Journal of Crohn\'s and Colitis 12/supplement_1 2019-06-13
2018 M de Bruyn, V Ballet, S Verstockt, B Verstockt, G Van Assche, M Ferrante, K Machiels, S Vermeire
OP003 Temporal changes in immune pathways with consecutive biological therapies as measured by serum proteomics
published pages: S003-S003, ISSN: 1873-9946, DOI:
Journal of Crohn\'s and Colitis 12/supplement_1 2019-06-13
2017 Wiebe Vanhove, Kris Nys, Ingrid Arijs, Isabelle Cleynen, Manuel Noben, Sebastiaan De Schepper, Gert Van Assche, Marc Ferrante, Séverine Vermeire
Biopsy-derived Intestinal Epithelial Cell Cultures for Pathway-based Stratification of Patients With Inflammatory Bowel Disease
published pages: 178-187, ISSN: 1873-9946, DOI: 10.1093/ecco-jcc/jjx122
Journal of Crohn\'s and Colitis 12/2 2019-06-13
2019 B Verstockt, S Verstockt, J Dehairs, V Ballet, H Blevi, W-J Wollants, C Breynaert, G Van Assche, S Vermeire, M Ferrante
P385 TREM1, the first anti-TNF specific biomarker guiding therapeutic decision
published pages: S300-S300, ISSN: 1873-9946, DOI:
Journal of Crohn\'s and Colitis 13/Supplement_1 2019-05-27
2019 Bram Verstockt, Sare Verstockt, Brecht Creyns, Sophie Tops, Gert Van Assche, Ann Gils, Jan L. Ceuppens, Séverine Vermeire, Marc Ferrante, Christine Breynaert
Mucosal IL13RA2 expression predicts nonresponse to anti-TNF therapy in Crohn\'s disease
published pages: 572-581, ISSN: 0269-2813, DOI: 10.1111/apt.15126
Alimentary Pharmacology & Therapeutics 49/5 2019-05-27
2018 Maaike Vancamelbeke, Vera Ballet, Nooshin Ardeshir Davani, Gert A. Van Assche, Marc Ferrante, Isabelle Cleynen, Severine Vermeire
Sa1784 - Unaffected First-Degree Relatives of Patients with Inflammatory Bowel Disease have Altered Profiles of Inflammation-Related Proteins
published pages: S-393, ISSN: 0016-5085, DOI:
Gastroenterology 154/6 2019-05-23
2017 K. Machiels, M. Pozuelo del Río, J. Sabino, A. Santiago, D. Campos, A. Wolthuis, A. De Buck van Overstraeten, A. D\'Hoore, G. Van Assche, M. Ferrante, P. Rutgeerts, G. De Hertogh, S. Vermeire, C. Manichanh
OP038 Impact of ileocecal resection in Crohn\'s disease patients on mucosal microbiota
published pages: S24-S25, ISSN: 1873-9946, DOI:
Journal of Crohn\'s and Colitis 11/suppl_1 2019-05-27
2019 Maaike Vancamelbeke, Thessa Laeremans, Wiebe Vanhove, Kaline Arnauts, Anabela Santo Ramalho, Ricard Farré, Isabelle Cleynen, Marc Ferrante, Séverine Vermeire
Butyrate does not protect against inflammation-induced loss of epithelial barrier function and cytokine production in primary cell monolayers from patients with ulcerative colitis
published pages: , ISSN: 1873-9946, DOI: 10.1093/ecco-jcc/jjz064
Journal of Crohn\'s and Colitis 2019-05-27
2019 S Verstockt, F Ver Donck, B Verstockt, E Glorieus, M De Decker, V Ballet, G Van Assche, D Laukens, M Ferrante, F Mana, M De Vos, S Vermeire, I Cleynen
P827 Up-regulation of IL17-related pathways in affected colon from ulcerative colitis compared with Crohn’s disease
published pages: S537-S538, ISSN: 1873-9946, DOI:
Journal of Crohn\'s and Colitis 13/Supplement_1 2019-06-06
2019 P Sudhakar, B Verstockt, B Creyns, J Cremer, G van Assche, T Korcsmaros, M Ferrante, S Vermeire
P001 Multi-omic data integration assisted identification of molecular features contributing to disease heterogeneity in Crohn\'s disease
published pages: S085-S086, ISSN: 1873-9946, DOI:
Journal of Crohn\'s and Colitis 13/Supplement_1 2019-05-27
2019 B Verstockt, P Sudahakar, B Creyns, S Verstockt, J Cremer, W-J Wollants, S Organe, T Korcsmaros, M Madgwick, G Van Assche, C Breynaert, S Vermeire, M Ferrante
DOP70 An integrated multi-omics biomarker predicting endoscopic response in ustekinumab treated patients with Crohn\'s disease
published pages: S072-S073, ISSN: 1873-9946, DOI:
Journal of Crohn\'s and Colitis 13/Supplement_1 2019-05-27
2018 Sare Verstockt, Bram Verstockt, Jens Van Bouwel, Wim Meert, Alvaro Cortés Calabuig, Vanessa Brys, Vera Ballet, Elien Glorieus, Muriel De Decker, Gert A. Van Assche, Pieter Hindryckx, Marc Ferrante, Debby Laukens, Fazia Mana, Martine De Vos, Severine Vermeire, Isabelle Cleynen
Tu1810 - Transcriptomic Profile of Inflamed Colonic Biopsies from Newly Diagnosed Crohn\'s Disease and Ulcerative Colitis Patients Depend on the age at Diagnosis
published pages: S-1026, ISSN: 0016-5085, DOI:
Gastroenterology 154/6 2019-06-06
2019 B Verstockt, S Verstockt, P Sudahakar, J Dehairs, H Blevi, G Van Assche, S Vermeire, M Ferrante
DOP38 A vedolizumab specific four-gene colonic signature accurately predicting future endoscopic remission in patients with inflammatory bowel disease
published pages: S048-S048, ISSN: 1873-9946, DOI:
Journal of Crohn\'s and Colitis 13/Supplement_1 2019-05-27
2019 Bram Verstockt, Sare Verstockt, Jonas Dehairs, Vera Ballet, Helene Blevi, Willem-Jan Wollants, Christine Breynaert, Gert Van Assche, Séverine Vermeire, Marc Ferrante
Low TREM1 expression in whole blood predicts anti-TNF response in inflammatory bowel disease
published pages: 733-742, ISSN: 2352-3964, DOI: 10.1016/j.ebiom.2019.01.027
EBioMedicine 40 2019-05-27
2019 C Caenepeel, S Vieira-Silva, B Verstockt, M Ferrante, J Raes, S Vermeire
P836 The predictive role of gut microbiota in treatment response to vedolizumab and ustekinumab in inflammatory bowel disease
published pages: S542-S542, ISSN: 1873-9946, DOI:
Journal of Crohn\'s and Colitis 13/Supplement_1 2019-06-06
2019 S Verstockt, F Ver Donck, B Verstockt, M Vancamelbeke, M De Decker, E Glorieus, V Ballet, G Van Assche, D Laukens, M Ferrante, F Mana, M De Vos, S Vermeire, I Cleynen
P821 Distinct and common gene expression profiles between inflamed ileum and colon of newly diagnosed CD patients
published pages: S533-S533, ISSN: 1873-9946, DOI:
Journal of Crohn\'s and Colitis 13/Supplement_1 2019-06-06
2018 Maaike Vancamelbeke, Sare Verstockt, Marc Ferrante, Gert A. Van Assche, Severine Vermeire, Isabelle Cleynen
Tu1808 - Colonic Inflammation Determines Ileal Gene Expression Changes in Ulcerative Colitis
published pages: S-1025-S-1026, ISSN: 0016-5085, DOI:
Gastroenterology 154/6 2019-05-27
2017 K. Machiels, V. Pascal, J. Sabino, A. Santiago, D. Campos, A. Wolthuis, A. De Buck van Overstraeten, A. D\'Hoore, G. Van Assche, M. Ferrante, P. Rutgeerts, C. Manichanh, S. Vermeire
DOP044 Relationship between microbiota and development of early postoperative Crohn\'s disease recurrence
published pages: S53-S53, ISSN: 1873-9946, DOI:
Journal of Crohn\'s and Colitis 11/suppl_1 2019-05-27
2019 J Brooks, D Modos, P Sudhakar, D Fazekas, A Zoufir, A Watson, M Tremelling, B Verstockt, S Vermeire, A Bender, S Carding, T Korcsmaros
OP10 Systems genomics of ulcerative colitis: combining GWAS and signalling networks for patient stratification and individualised drug targeting in ulcerative colitis
published pages: S006-S007, ISSN: 1873-9946, DOI:
Journal of Crohn\'s and Colitis 13/Supplement_1 2019-05-27
2018 Sare Verstockt, Elien Glorieus, Muriel De Decker, Bram Verstockt, Nooshin Ardeshir Davani, Vera Ballet, Gert A. Van Assche, Pieter Hindryckx, Marc Ferrante, Debby Laukens, Fazia Mana, Martine De Vos, Severine Vermeire, Isabelle Cleynen
Sa1781 - Serological Markers Define Newly Diagnosed Crohn\'s Disease and Ulcerative Colitis Based on the age at Diagnosis
published pages: S-392, ISSN: 0016-5085, DOI:
Gastroenterology 154/6 2019-05-27
2017 M. Vancamelbeke, J. Sabino, L. Deroover, G. Vandermeulen, A. Luypaerts, M. Ferrante, G. Falony, S. Vieira-Silva, K. Verbeke, J. Raes, I. Cleynen, S. Vermeire
P774 Metagenomics and metabolomics of patients with inflammatory bowel disease and their unaffected relatives
published pages: S476-S477, ISSN: 1873-9946, DOI:
Journal of Crohn\'s and Colitis 11/suppl_1 2019-05-27
2018 Magali de Bruyn, Vera Ballet, Sare Verstockt, Bram Verstockt, Gert A. Van Assche, Marc Ferrante, Kathleen Machiels, Severine Vermeire
Tu1799 - Serum Proteomic Profiling Reveals Changes in Inflammatory Profiles with Consecutive Biological Therapies in Patients with Inflammatory Bowel Disease
published pages: S-1023, ISSN: 0016-5085, DOI:
Gastroenterology 154/6 2019-05-27
2018 Kathleen Machiels, Magali de Bruyn, Sare Verstockt, Bram Verstockt, Gert A. Van Assche, Albert Wolthuis, Andre D\'Hoore, Marc Ferrante, Severine Vermeire
Su1794 - Discrimination of Endoscopic Postoperative Recurrence in Patients with Crohn\'s Disease using Serological Inflammatory Markers
published pages: S-586-S-587, ISSN: 0016-5085, DOI:
Gastroenterology 154/6 2019-05-27
2019 K Machiels, M Ferrante, N Davani, A Wolthuis, A D’Hoore, S Vermeire
OP30 Serum proteomic profiling predicts and diagnoses pouchitis in ulcerative colitis patients undergoing ileal pouch-anal anastomosis
published pages: S022-S023, ISSN: 1873-9946, DOI:
Journal of Crohn\'s and Colitis 13/Supplement_1 2019-05-27

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