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Secret-Cells SIGNED

Cellular diversity and stress-induced cell-state switches in the mammalian hypothalamus

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EC-Contrib. €

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 Secret-Cells project word cloud

Explore the words cloud of the Secret-Cells project. It provides you a very rough idea of what is the project "Secret-Cells" about.

structural    neuron    stress    reflecting    adrenal    release    exhibit    stimulus    network    gt    link    relationships    functional    pro    somatomotor    subclass    switches    identity    sensor    diversity    expresses    describe    dynamic    interface    circulation    afferent    nuclei    crh    loci    neuronal    environmental    transcriptome    neurons    constitutively    dependent    organizational    single    unprecedented    fast    prior    biophysical    landscape    domains    adaptations    released    origins    25    breadth    cell    indispensable    co    limit    date    hypothalamus    molecular    portion    insufficiency    corticotropin    classifications    subtypes    bodily    resolve    addison    rules    hypothalamic    function    insulin    orchestration    reveal    conceptual    metabolic    nucleus    resolution    acute    disease    secretagogin    free    neuroendocrine    calcium    cellular    identities    organization    hierarchy    cues    output    surpassing    markers    magno    neurotransmitter    gaps    releasing    parvocellular    decipher    expressional    resistance    chronic    lack    physiological    synapse    undergo    unaccounted    recruitment    paraventricular    template    autonomic    neuropeptide    hormone   

Project "Secret-Cells" data sheet

The following table provides information about the project.

Coordinator
MEDIZINISCHE UNIVERSITAET WIEN 

Organization address
address: SPITALGASSE 23
city: WIEN
postcode: 1090
website: www.meduniwien.ac.at

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Total cost 2˙422˙698 €
 EC max contribution 2˙422˙698 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-AdG
 Funding Scheme ERC-ADG
 Starting year 2016
 Duration (year-month-day) from 2016-09-01   to  2021-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MEDIZINISCHE UNIVERSITAET WIEN AT (WIEN) coordinator 2˙422˙698.00

Map

 Project objective

The hypothalamus is an essential interface among neuroendocrine, autonomic and somatomotor systems, allowing dynamic bodily adaptations to environmental cues via the orchestration of complex physiological processes. Hypothalamic nuclei exhibit unprecedented molecular, structural and functional diversity of neurons, reflecting the breadth of neuroendocrine output. To date, a significant portion of hypothalamic neurons remains unaccounted for given the lack of identity markers. For known hypothalamic neuron subtypes, their ability to undergo stimulus-dependent expressional switches challenge their neurotransmitter- and neuropeptide-based classifications. These gaps of knowledge limit conceptual advances on neuronal loci, dynamic synapse recruitment and network hierarchy for metabolic control, and the molecular origins of disease. We have established the single cell transcriptome landscape of the paraventricular nucleus including its magno- and parvocellular domains. We will use this template to reveal novel cell identities and cell-state switches upon acute stress. We describe >25 neuronal subtypes under stress-free conditions, surpassing the resolution of any prior approach. Thus, we will resolve neurotransmitter-neuropeptide relationships at the single neuron level, with a focus on corticotropin-releasing hormone (CRH), determine biophysical parameters of CRH co-release with a fast neurotransmitter, and decipher changes to afferent organization upon stress. A novel parvocellular subclass constitutively expresses secretagogin, a calcium-sensor, which is indispensable for CRH release. We will link secretagogin loss-of-function in CRH neurons to Addison’s disease (chronic adrenal insufficiency associated with insulin resistance). Moreover, we propose a (pro-)hormone-like role for secretagogin released from CRH neurons into the circulation. Overall, our work program will produce new understanding on cellular diversity and organizational rules in the hypothalamus.

 Publications

year authors and title journal last update
List of publications.
2018 Andras Gabor Miklosi, Giorgia Del Favero, Doris Marko, Tibor Harkany, Gert Lubec
Resolution Matters: Correlating Quantitative Proteomics and Nanoscale-Precision Microscopy for Reconstructing Synapse Identity
published pages: 1800139, ISSN: 1615-9853, DOI: 10.1002/pmic.201800139
PROTEOMICS 18/14 2020-04-08
2016 Ming-Dong Zhang, Swapnali Barde, Edit Szodorai, Anna Josephson, Nicholas Mitsios, Masahiko Watanabe, Johannes Attems, Gert Lubec, Gábor G. Kovács, Mathias Uhlén, Jan Mulder, Tibor Harkany, Tomas Hökfelt
Comparative anatomical distribution of neuronal calcium-binding protein (NECAB) 1 and -2 in rodent and human spinal cord
published pages: 3803-3823, ISSN: 1863-2653, DOI: 10.1007/s00429-016-1191-3
Brain Structure and Function 221/7 2020-04-08
2018 Roman A. Romanov, Robert S. Lasher, Brigit High, Logan E. Savidge, Adam Lawson, Olga A. Rogachevskaja, Haitian Zhao, Vadim V. Rogachevsky, Marina F. Bystrova, Gleb D. Churbanov, Igor Adameyko, Tibor Harkany, Ruibiao Yang, Grahame J. Kidd, Philippe Marambaud, John C. Kinnamon, Stanislav S. Kolesnikov, Thomas E. Finger
Chemical synapses without synaptic vesicles: Purinergic neurotransmission through a CALHM1 channel-mitochondrial signaling complex
published pages: eaao1815, ISSN: 1937-9145, DOI: 10.1126/scisignal.aao1815
Science Signaling 11/529 2020-04-08
2017 Pia Rivetti di Val Cervo, Roman A Romanov, Giada Spigolon, D?bora Masini, Elisa Mart?n-Monta?ez, Enrique M Toledo, Gioele La Manno, Michael Feyder, Christian Pifl, Yi-Han Ng, Sara Padrell S?nchez, Sten Linnarsson, Marius Wernig, Tibor Harkany, Gilberto Fisone, Ernest Arenas
Induction of functional dopamine neurons from human astrocytes in vitro and mouse astrocytes in a Parkinson\'s disease model
published pages: 444-452, ISSN: 1087-0156, DOI: 10.1038/nbt.3835
Nature Biotechnology 35/5 2020-04-08
2018 Ivan Milenkovic, Tamara Stojanovic, Eleonora Aronica, Livia Fülöp, Zsolt Bozsó, Zoltán Máté, Yuchio Yanagawa, Homa Adle-Biassette, Gert Lubec, Gábor Szabó, Tibor Harkany, Gábor G. Kovács, Erik Keimpema
GABAA receptor subunit deregulation in the hippocampus of human foetuses with Down syndrome
published pages: , ISSN: 1863-2653, DOI: 10.1007/s00429-017-1563-3
Brain Structure and Function 2020-04-08
2017 Jin Li, Tamara Casteels, Thomas Frogne, Camilla Ingvorsen, Christian Honor?, Monica Courtney, Kilian V.M. Huber, Nicole Schmitner, Robin A. Kimmel, Roman A. Romanov, Caterina Sturtzel, Charles-Hugues Lardeau, Johanna Klughammer, Matthias Farlik, Sara Sdelci, Andhira Vieira, Fabio Avolio, Fran?ois Briand, Igor Baburin, Peter M?jek, Florian M. Pauler, Thomas Penz, Alexey Stukalov, Manuela Gridling, Katja Parapatics, Charlotte Barbieux, Ekaterine Berishvili, Andreas Spittler, Jacques Colinge, Keiryn L. Bennett, Steffen Hering, Thierry Sulpice, Christoph Bock, Martin Distel, Tibor Harkany, Dirk Meyer, Giulio Superti-Furga, Patrick Collombat, Jacob Hecksher-S?rensen, Stefan Kubicek
Artemisinins Target GABA A Receptor Signaling and Impair ? Cell Identity
published pages: 86-100.e15, ISSN: 0092-8674, DOI: 10.1016/j.cell.2016.11.010
Cell 168/1-2 2020-04-08
2017 Daniela Calvigioni, Zoltán Máté, János Fuzik, Fatima Girach, Ming-Dong Zhang, Andrea Varro, Johannes Beiersdorf, Christian Schwindling, Yuchio Yanagawa, Graham J. Dockray, Chris J. McBain, Tomas Hökfelt, Gábor Szabó, Erik Keimpema, Tibor Harkany
Functional Differentiation of Cholecystokinin-Containing Interneurons Destined for the Cerebral Cortex
published pages: bhw094, ISSN: 1047-3211, DOI: 10.1093/cercor/bhw094
Cerebral Cortex 2020-04-08
2017 Tibor Harkany, Tamas L. Horvath
(S)Pot on Mitochondria: Cannabinoids Disrupt Cellular Respiration to Limit Neuronal Activity
published pages: 8-10, ISSN: 1550-4131, DOI: 10.1016/j.cmet.2016.12.020
Cell Metabolism 25/1 2020-04-08
2017 J?nos Hanics, Edit Szodorai, Giuseppe Tortoriello, Katarzyna Malenczyk, Erik Keimpema, Gert Lubec, Zs?fia Hevesi, Mirjam I. Lutz, M?rk Kozsurek, Zita Pusk?r, Zsuzsanna E. T?th, Ludwig Wagner, G?bor G. Kov?cs, Tomas G. M. H?kfelt, Tibor Harkany, Al?n Alp?r
Secretagogin-dependent matrix metalloprotease-2 release from neurons regulates neuroblast migration
published pages: E2006-E2015, ISSN: 0027-8424, DOI: 10.1073/pnas.1700662114
Proceedings of the National Academy of Sciences 114/10 2020-04-08
2017 Katarzyna Malenczyk, Fatima Girach, Edit Szodorai, Petter Storm, Åsa Segerstolpe, Giuseppe Tortoriello, Robert Schnell, Jan Mulder, Roman A Romanov, Erzsébet Borók, Fabiana Piscitelli, Vincenzo Di Marzo, Gábor Szabó, Rickard Sandberg, Stefan Kubicek, Gert Lubec, Tomas Hökfelt, Ludwig Wagner, Leif Groop, Tibor Harkany
A TRPV1‐to‐secretagogin regulatory axis controls pancreatic β‐cell survival by modulating protein turnover
published pages: e201695347, ISSN: 0261-4189, DOI: 10.15252/embj.201695347
The EMBO Journal 2020-04-08
2017 Roman A Romanov, Al?n Alp?r, Tomas H?kfelt, Tibor Harkany
Molecular diversity of corticotropin-releasing hormone mRNA-containing neurons in the hypothalamus
published pages: R161-R172, ISSN: 0022-0795, DOI: 10.1530/JOE-16-0256
Journal of Endocrinology 232/3 2020-04-08
2016 S. Marques, A. Zeisel, S. Codeluppi, D. van Bruggen, A. Mendanha Falcao, L. Xiao, H. Li, M. Haring, H. Hochgerner, R. A. Romanov, D. Gyllborg, A. B. Munoz-Manchado, G. La Manno, P. Lonnerberg, E. M. Floriddia, F. Rezayee, P. Ernfors, E. Arenas, J. Hjerling-Leffler, T. Harkany, W. D. Richardson, S. Linnarsson, G. Castelo-Branco
Oligodendrocyte heterogeneity in the mouse juvenile and adult central nervous system
published pages: 1326-1329, ISSN: 0036-8075, DOI: 10.1126/science.aaf6463
Science 352/6291 2020-04-08
2016 Roman A Romanov, Amit Zeisel, Joanne Bakker, Fatima Girach, Arash Hellysaz, Raju Tomer, Al?n Alp?r, Jan Mulder, Fr?d?ric Clotman, Erik Keimpema, Brian Hsueh, Ailey K Crow, Henrik Martens, Christian Schwindling, Daniela Calvigioni, Jaideep S Bains, Zolt?n M?t?, G?bor Szab?, Yuchio Yanagawa, Ming-Dong Zhang, Andre Rendeiro, Matthias Farlik, Mathias Uhl?n, Peer Wulff, Christoph Bock, Christian Broberger, Karl Deisseroth, Tomas H?kfelt, Sten Linnarsson, Tamas L Horvath, Tibor Harkany
Molecular interrogation of hypothalamic organization reveals distinct dopamine neuronal subtypes
published pages: 176-188, ISSN: 1097-6256, DOI: 10.1038/nn.4462
Nature Neuroscience 20/2 2020-04-08
2017 Meinrad Drexel, Roman A. Romanov, James Wood, Stefan Weger, Regine Heilbronn, Peer Wulff, Ramon O. Tasan, Tibor Harkany, Günther Sperk
Selective silencing of hippocampal parvalbumin interneurons induces development of recurrent spontaneous limbic seizures in mice
published pages: 3456-16, ISSN: 0270-6474, DOI: 10.1523/JNEUROSCI.3456-16.2017
The Journal of Neuroscience 2020-04-08
2017 Changgeng Peng, Lili Li, Ming-Dong Zhang, Carolina Bengtsson Gonzales, Marc Parisien, Inna Belfer, Dmitry Usoskin, Hind Abdo, Alessandro Furlan, Martin Häring, Francois Lallemend, Tibor Harkany, Luda Diatchenko, Tomas Hökfelt, Jens Hjerling-Leffler, Patrik Ernfors
miR-183 cluster scales mechanical pain sensitivity by regulating basal and neuropathic pain genes
published pages: 1168-1171, ISSN: 0036-8075, DOI: 10.1126/science.aam7671
Science 356/6343 2020-04-08
2019 Roman A. Romanov, Alán Alpár, Tomas Hökfelt, Tibor Harkany
Unified Classification of Molecular, Network, and Endocrine Features of Hypothalamic Neurons
published pages: , ISSN: 0147-006X, DOI: 10.1146/annurev-neuro-070918-050414
Annual Review of Neuroscience 42/1 2020-04-08
2018 Katarzyna Malenczyk, Edit Szodorai, Robert Schnell, Gert Lubec, Gábor Szabó, Tomas Hökfelt, Tibor Harkany
Secretagogin protects Pdx1 from proteasomal degradation to control a transcriptional program required for β cell specification
published pages: 108-120, ISSN: 2212-8778, DOI: 10.1016/j.molmet.2018.05.019
Molecular Metabolism 14 2020-04-08
2018 Ming-Dong Zhang, Jie Su, Csaba Adori, Valentina Cinquina, Katarzyna Malenczyk, Fatima Girach, Changgeng Peng, Patrik Ernfors, Peter Löw, Lotta Borgius, Ole Kiehn, Masahiko Watanabe, Mathias Uhlén, Nicholas Mitsios, Jan Mulder, Tibor Harkany, Tomas Hökfelt
Ca2+-binding protein NECAB2 facilitates inflammatory pain hypersensitivity
published pages: 3757-3768, ISSN: 0021-9738, DOI: 10.1172/jci120913
Journal of Clinical Investigation 128/9 2020-04-08
2018 Edit Szodorai, Konstantina Bampali, Roman A. Romanov, Siegfried Kasper, Tomas Hökfelt, Margot Ernst, Gert Lubec, Tibor Harkany
Diversity matters: combinatorial information coding by GABA A receptor subunits during spatial learning and its allosteric modulation
published pages: 142-159, ISSN: 0898-6568, DOI: 10.1016/j.cellsig.2018.07.003
Cellular Signalling 50 2020-04-08
2019 Roman A. Romanov, Alán Alpár, Tomas Hökfelt, Tibor Harkany
Unified Classification of Molecular, Network, and Endocrine Features of Hypothalamic Neurons
published pages: , ISSN: 0147-006X, DOI: 10.1146/annurev-neuro-070918-050414
Annual Review of Neuroscience 42/1 2020-04-08
2019 Solomiia Korchynska, Mirjam I. Lutz, Erzsébet Borók, Johannes Pammer, Valentina Cinquina, Nataliya Fedirko, Andrew J. Irving, Ken Mackie, Tibor Harkany, Erik Keimpema
GPR55 controls functional differentiation of self-renewing epithelial progenitors for salivation
published pages: , ISSN: 2379-3708, DOI: 10.1172/jci.insight.122947
JCI Insight 4/4 2020-04-08
2019 Alán Alpár, Marco Benevento, Roman A Romanov, Tomas Hökfelt, Tibor Harkany
Hypothalamic cell diversity: non-neuronal codes for long-distance volume transmission by neuropeptides
published pages: 16-23, ISSN: 0959-4388, DOI: 10.1016/j.conb.2018.10.012
Current Opinion in Neurobiology 56 2020-04-08
2018 A. Alpár, T. Harkany
Novel insights into the spatial and temporal complexity of hypothalamic organization through precision methods allowing nanoscale resolution
published pages: 568-580, ISSN: 0954-6820, DOI: 10.1111/joim.12815
Journal of Internal Medicine 284/6 2020-04-08
2018 Alán Alpár, Péter Zahola, János Hanics, Zsófia Hevesi, Solomiia Korchynska, Marco Benevento, Christian Pifl, Gergely Zachar, Jessica Perugini, Ilenia Severi, Patrick Leitgeb, Joanne Bakker, Andras G Miklosi, Evgenii Tretiakov, Erik Keimpema, Gloria Arque, Ramon O Tasan, Günther Sperk, Katarzyna Malenczyk, Zoltán Máté, Ferenc Erdélyi, Gábor Szabó, Gert Lubec, Miklós Palkovits, Antonio Giordano, Tomas GM Hökfelt, Roman A Romanov, Tamas L Horvath, Tibor Harkany
Hypothalamic CNTF volume transmission shapes cortical noradrenergic excitability upon acute stress
published pages: e100087, ISSN: 0261-4189, DOI: 10.15252/embj.2018100087
The EMBO Journal 37/21 2020-04-08
2019 Solomiia Korchynska, Mirjam I. Lutz, Erzsébet Borók, Johannes Pammer, Valentina Cinquina, Nataliya Fedirko, Andrew J. Irving, Ken Mackie, Tibor Harkany, Erik Keimpema
GPR55 controls functional differentiation of self-renewing epithelial progenitors for salivation
published pages: , ISSN: 2379-3708, DOI: 10.1172/jci.insight.122947
JCI Insight 4/4 2020-04-08
2019 Alán Alpár, Marco Benevento, Roman A Romanov, Tomas Hökfelt, Tibor Harkany
Hypothalamic cell diversity: non-neuronal codes for long-distance volume transmission by neuropeptides
published pages: 16-23, ISSN: 0959-4388, DOI: 10.1016/j.conb.2018.10.012
Current Opinion in Neurobiology 56 2020-04-08
2018 Merav Cohen, Amir Giladi, Anna-Dorothea Gorki, Dikla Gelbard Solodkin, Mor Zada, Anastasiya Hladik, Andras Miklosi, Tomer-Meir Salame, Keren Bahar Halpern, Eyal David, Shalev Itzkovitz, Tibor Harkany, Sylvia Knapp, Ido Amit
Lung Single-Cell Signaling Interaction Map Reveals Basophil Role in Macrophage Imprinting
published pages: 1031-1044.e18, ISSN: 0092-8674, DOI: 10.1016/j.cell.2018.09.009
Cell 175/4 2020-04-08

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