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CMDNAUP SIGNED

Composition and Mechanism of the DNA-uptake Pilus of Vibrio cholerae

Total Cost €

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EC-Contrib. €

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Partnership

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 CMDNAUP project word cloud

Explore the words cloud of the CMDNAUP project. It provides you a very rough idea of what is the project "CMDNAUP" about.

cholera    extensions    prospective    innovative    functions    question    forms    pathogens    aquatic    purified    gene    components    blokesch    ubiquitous    biological    virulence    negative    spread    environment    proteins    chitinous    evolution    models    pandemic    mode    resistance    mainly    machinery    exoskeletons    pili    tfp    training    visualise    failed    elucidate    bacterial    natural    causes    assembly    pioneered    roles    almost    fellow    lab    bacteria    epfl    zooplankton    mechanism    maximum    horizontal    determined    dna    cholerae    notably    play    combine    molecular    composition    sophisticated    vibrio    implying    nanomachine    rapid    action    pathogen    free    genetic    positive    genes    bacterium    chance    disease    cell    attachment    follow    membrane    hgt    surface    nothing    actually    form    mechanisms    answer    bacillus    competent    motility    encoding    subtilis    pilus    minimal    outer    competence    works    initiates    conserved    gram    visualised    naturally    infrastructures    antibiotic    polymeric    human    had    underlying    transfer   

Project "CMDNAUP" data sheet

The following table provides information about the project.

Coordinator
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE 

Organization address
address: BATIMENT CE 3316 STATION 1
city: LAUSANNE
postcode: 1015
website: www.epfl.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Project website https://blokesch-lab.epfl.ch
 Total cost 175˙419 €
 EC max contribution 175˙419 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-09-01   to  2018-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE CH (LAUSANNE) coordinator 175˙419.00

Map

 Project objective

Horizontal gene transfer (HGT) allows rapid bacterial evolution including the spread of genes encoding antibiotic resistance and virulence factors. The Gram-negative bacterium Vibrio cholerae is an important human pathogen that causes the pandemic disease Cholera. In its natural aquatic environment growth on the chitinous exoskeletons of zooplankton initiates the development of ‘Natural Competence’, a widespread and key form of HGT that allows bacteria to take up free DNA from the environment. DNA uptake involves a sophisticated nanomachine known as a Type IV Pilus (TFP), which forms polymeric extensions from the cell surface, are ubiquitous throughout bacteria and play a wide range of other roles such as surface motility and attachment. Notably, this machinery is conserved in other naturally competent bacteria including in several important human pathogens, implying a common mode of action. Work on this machinery has mainly been done in Gram-positive models like Bacillus subtilis but had failed to visualise an uptake pilus. Recently, the Blokesch lab visualised a DNA uptake pilus extending from the outer membrane of V. cholerae and determined the minimal known components needed for its assembly. However, we still know almost nothing about how this machinery actually works to bring DNA into the cell. To answer this important question and elucidate the underlying molecular mechanisms we will follow two main objectives. 1. We will determine the composition of purified DNA-uptake pili and investigate the functions of the identified proteins. 2. We will combine innovative genetic and cell-biological approaches to investigate the mechanism of DNA uptake. The Blokesch lab at EPFL has pioneered genetic and cell biological methods for studying competence in V. cholerae and has state-of-the-art equipment and infrastructures that offer the prospective fellow the maximum chance of success and the best-possible training through the research.

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The information about "CMDNAUP" are provided by the European Opendata Portal: CORDIS opendata.

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