Opendata, web and dolomites


Composition and Mechanism of the DNA-uptake Pilus of Vibrio cholerae

Total Cost €


EC-Contrib. €






 CMDNAUP project word cloud

Explore the words cloud of the CMDNAUP project. It provides you a very rough idea of what is the project "CMDNAUP" about.

mode    actually    natural    spread    aquatic    competence    innovative    follow    vibrio    gene    outer    prospective    exoskeletons    resistance    chitinous    polymeric    question    failed    antibiotic    pili    sophisticated    works    initiates    bacterium    nothing    combine    lab    subtilis    bacterial    extensions    competent    functions    determined    biological    pilus    virulence    positive    attachment    naturally    mechanisms    components    underlying    bacillus    transfer    free    tfp    evolution    bacteria    blokesch    ubiquitous    visualise    action    motility    surface    had    training    encoding    chance    nanomachine    notably    machinery    zooplankton    maximum    roles    pathogens    cholerae    play    dna    mechanism    pandemic    disease    genes    models    elucidate    causes    human    form    pioneered    epfl    almost    infrastructures    proteins    answer    environment    rapid    genetic    purified    forms    implying    cell    cholera    composition    hgt    negative    horizontal    gram    fellow    assembly    membrane    conserved    pathogen    molecular    mainly    minimal    visualised   

Project "CMDNAUP" data sheet

The following table provides information about the project.


Organization address
address: BATIMENT CE 3316 STATION 1
postcode: 1015

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Project website
 Total cost 175˙419 €
 EC max contribution 175˙419 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-09-01   to  2018-08-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Horizontal gene transfer (HGT) allows rapid bacterial evolution including the spread of genes encoding antibiotic resistance and virulence factors. The Gram-negative bacterium Vibrio cholerae is an important human pathogen that causes the pandemic disease Cholera. In its natural aquatic environment growth on the chitinous exoskeletons of zooplankton initiates the development of ‘Natural Competence’, a widespread and key form of HGT that allows bacteria to take up free DNA from the environment. DNA uptake involves a sophisticated nanomachine known as a Type IV Pilus (TFP), which forms polymeric extensions from the cell surface, are ubiquitous throughout bacteria and play a wide range of other roles such as surface motility and attachment. Notably, this machinery is conserved in other naturally competent bacteria including in several important human pathogens, implying a common mode of action. Work on this machinery has mainly been done in Gram-positive models like Bacillus subtilis but had failed to visualise an uptake pilus. Recently, the Blokesch lab visualised a DNA uptake pilus extending from the outer membrane of V. cholerae and determined the minimal known components needed for its assembly. However, we still know almost nothing about how this machinery actually works to bring DNA into the cell. To answer this important question and elucidate the underlying molecular mechanisms we will follow two main objectives. 1. We will determine the composition of purified DNA-uptake pili and investigate the functions of the identified proteins. 2. We will combine innovative genetic and cell-biological approaches to investigate the mechanism of DNA uptake. The Blokesch lab at EPFL has pioneered genetic and cell biological methods for studying competence in V. cholerae and has state-of-the-art equipment and infrastructures that offer the prospective fellow the maximum chance of success and the best-possible training through the research.

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The information about "CMDNAUP" are provided by the European Opendata Portal: CORDIS opendata.

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