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Socs3 gene in oocyte maturation and fertilisation - a novel link between inflammation and infertility

Total Cost €


EC-Contrib. €






 OOCSOCS project word cloud

Explore the words cloud of the OOCSOCS project. It provides you a very rough idea of what is the project "OOCSOCS" about.

roles    followed    consequently    exchange    receive    benefit    genetic    training    quality    veselovska    world    ablate    experimental    edge    relation    coming    genome    central    regulating    socs3    arising    fertility    she    date    exploits    functional    oogenesis    substantially    skills    maternal    host    characterisation    contemporary    immune    maturation    represented    group    chromosomal    line    women    bohemia    treat    mouse    age    biologist    infertility    renown    candidate    western    molecular    independent    couples    network    award    complete    wealth    university    influences    ideas    mammalian    prevalent    negatively    cutting    oocyte    bioinformatics    trend    synergies    native    eastern    segregation    prevent    physiological    identification    region    biology    correct    fertilisation    underrepresented    complementary    orientated    laboratory    collaborators    south    joining    gene    therapeutic    career    uk    female    developmental    multidisciplinary       germ    countries    fellowship    dr    increasing    source    ambitions   

Project "OOCSOCS" data sheet

The following table provides information about the project.


Organization address
address: BRANISOVSKA 31A
postcode: 370 05

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Czech Republic [CZ]
 Total cost 142˙720 €
 EC max contribution 142˙720 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-06-01   to  2021-07-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Increasing maternal age, a prevalent trend in developed countries, negatively influences oocyte quality and consequently female fertility – 5% of all couples experience fertility problems arising from a physiological source in the women. To develop novel approaches to prevent or treat infertility, a more complete understanding of oogenesis is required. The host laboratory has recently identified the Socs3 gene, to date associated only with roles in the immune system, as a novel strong candidate regulating oogenesis. The project exploits a genetic approach to ablate the Socs3 gene from the female germ-line and addresses the role of Socs3 gene during mouse oocyte maturation and fertilisation, e.g. in correct chromosomal segregation, followed by further detailed and cutting-edge functional characterisation. The results could lead to the identification of novel therapeutic targets to treat female infertility. Dr. Veselovska, coming from a world-renown institute, is joining a well-established early mammalian development orientated host group, within the Department of Molecular Biology at the University of South Bohemia. Synergies arising from this multidisciplinary proposal will benefit both host and applicant. In particular, Dr. Veselovska is bringing a wealth of highly relevant mouse oocyte experience and bioinformatics skills for genome-scale analyses that are currently an underrepresented skills set in the host laboratory and host institution, as well as her network of UK based collaborators. She will receive training that is both complementary to her current knowledge and skills and novel and highly contemporary in relation to the experimental approaches used. Consequently, the fellowship award will substantially further the Dr. Veselovska’s career ambitions to become an independent early mammalian developmental biologist within her native Central European region, and facilitate the under-represented exchange of ideas between Western and Eastern European countries.

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The information about "OOCSOCS" are provided by the European Opendata Portal: CORDIS opendata.

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