Explore the words cloud of the MESOTAS-SIEVE project. It provides you a very rough idea of what is the project "MESOTAS-SIEVE" about.
The following table provides information about the project.
TECHNISCHE UNIVERSITEIT EINDHOVEN
|Coordinator Country||Netherlands [NL]|
|Total cost||150˙000 €|
|EC max contribution||150˙000 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2016-10-01 to 2018-03-31|
Take a look of project's partnership.
|1||TECHNISCHE UNIVERSITEIT EINDHOVEN||NL (EINDHOVEN)||coordinator||150˙000.00|
This project will demonstrate the technical and commercial viability of the MESOTAS-SIEVE bioreactor, a novel 3D brain-on-chip microculture system. This allows the culturing and in vitro functional analysis of neuronal networks that mimic the human brain in a physiologically much more relevant way than conventional cell culture systems or animal models. Therefore, the MESOTAS-SIEVE system has great potential towards the realisation of tissue models of the brain for drug efficacy and toxicity assays. This project is based on exciting discoveries done in the ERC Starting Grant project MESOTAS (2011-2016). In MESOTAS, a bioreactor on a microelectrode array (MEA) has been developed to study the ‘natural’ behaviour of 3D neuronal networks. For this bioreactor, a neuronal cell line has been identified that uniquely survives >30 days and forms neuronal networks. To further improve function and network formation capacity, this project will integrate a micro-sieve at the bottom of the MESOTAS bioreactor to improve cell shape, function and optimal connection to the MEA electrodes for single-cell readout of activity. PoC of this MESOTAS-SIEVE bioreactor provides the basis for further development towards a commercial brain-on-a-chip platform. The first steps towards commercialization of MESOTAS-SIEVE will be performed as part of this project and initial industry contact are already in place. During the project we will establish a solid business model, including intellectual property (IP) protection, a market/competitor analysis, and an exploitation plan. Towards the end of this project the “data package” will be used to attract further financing towards commercialization.
|year||authors and title||journal||last update|
Linda H.M. van de Burgwal, Pim van Dorst, Henk ViÃ«tor, Regina Luttge, Eric Claassen
Hybrid business models for â€˜Organ-on-a-Chipâ€™ technology: The best of both worlds
published pages: 55-63, ISSN: 2213-4344, DOI: 10.1016/j.phanu.2018.02.001
Jean-Philippe Frimat, Bart Schurink, Regina Luttge
Passive pumping for the parallel trapping of single neurons onto a microsieve electrode array
published pages: 06GA01, ISSN: 2166-2754, DOI: 10.1116/1.4991827
|Journal of Vacuum Science & Technology B, Nanotechnology and Microelectronics: Materials, Processing, Measurement, and Phenomena 35/6||2019-06-13|
Emma Moonen, Regina Luttge, Jean-Philippe Frimat
Single cell trapping by capillary pumping using NOA81 replica moulded stencils
published pages: , ISSN: 0167-9317, DOI: 10.1016/j.mee.2018.04.010
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