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Sieving neuronal network communication

Total Cost €


EC-Contrib. €






Project "MESOTAS-SIEVE" data sheet

The following table provides information about the project.


Organization address
address: GROENE LOPER 3
postcode: 5612 AE

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 150˙000 €
 EC max contribution 150˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-PoC
 Funding Scheme ERC-POC
 Starting year 2016
 Duration (year-month-day) from 2016-10-01   to  2018-03-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

This project will demonstrate the technical and commercial viability of the MESOTAS-SIEVE bioreactor, a novel 3D brain-on-chip microculture system. This allows the culturing and in vitro functional analysis of neuronal networks that mimic the human brain in a physiologically much more relevant way than conventional cell culture systems or animal models. Therefore, the MESOTAS-SIEVE system has great potential towards the realisation of tissue models of the brain for drug efficacy and toxicity assays. This project is based on exciting discoveries done in the ERC Starting Grant project MESOTAS (2011-2016). In MESOTAS, a bioreactor on a microelectrode array (MEA) has been developed to study the ‘natural’ behaviour of 3D neuronal networks. For this bioreactor, a neuronal cell line has been identified that uniquely survives >30 days and forms neuronal networks. To further improve function and network formation capacity, this project will integrate a micro-sieve at the bottom of the MESOTAS bioreactor to improve cell shape, function and optimal connection to the MEA electrodes for single-cell readout of activity. PoC of this MESOTAS-SIEVE bioreactor provides the basis for further development towards a commercial brain-on-a-chip platform. The first steps towards commercialization of MESOTAS-SIEVE will be performed as part of this project and initial industry contact are already in place. During the project we will establish a solid business model, including intellectual property (IP) protection, a market/competitor analysis, and an exploitation plan. Towards the end of this project the “data package” will be used to attract further financing towards commercialization.


year authors and title journal last update
List of publications.
2018 Linda H.M. van de Burgwal, Pim van Dorst, Henk Viëtor, Regina Luttge, Eric Claassen
Hybrid business models for ‘Organ-on-a-Chip’ technology: The best of both worlds
published pages: 55-63, ISSN: 2213-4344, DOI: 10.1016/j.phanu.2018.02.001
PharmaNutrition 6/2 2019-06-13
2017 Jean-Philippe Frimat, Bart Schurink, Regina Luttge
Passive pumping for the parallel trapping of single neurons onto a microsieve electrode array
published pages: 06GA01, ISSN: 2166-2754, DOI: 10.1116/1.4991827
Journal of Vacuum Science & Technology B, Nanotechnology and Microelectronics: Materials, Processing, Measurement, and Phenomena 35/6 2019-06-13
2018 Emma Moonen, Regina Luttge, Jean-Philippe Frimat
Single cell trapping by capillary pumping using NOA81 replica moulded stencils
published pages: , ISSN: 0167-9317, DOI: 10.1016/j.mee.2018.04.010
Microelectronic Engineering 2019-06-13

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The information about "MESOTAS-SIEVE" are provided by the European Opendata Portal: CORDIS opendata.

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