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REMIX SIGNED

Regulation of mitochondrial expression

Total Cost €

0

EC-Contrib. €

0

Partnership

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Project "REMIX" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAET ZU KOELN 

Organization address
address: ALBERTUS MAGNUS PLATZ
city: KOELN
postcode: 50931
website: www.uni-koeln.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website http://www.remix-itn.eu
 Total cost 3˙920˙630 €
 EC max contribution 3˙920˙630 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2016
 Funding Scheme MSCA-ITN-ETN
 Starting year 2016
 Duration (year-month-day) from 2016-10-01   to  2020-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAET ZU KOELN DE (KOELN) coordinator 643˙809.00
2    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) participant 546˙575.00
3    UNIVERSITY OF NEWCASTLE UPON TYNE UK (NEWCASTLE UPON TYNE) participant 546˙575.00
4    GOETEBORGS UNIVERSITET SE (GOETEBORG) participant 527˙318.00
5    STOCKHOLMS UNIVERSITET SE (STOCKHOLM) participant 527˙318.00
6    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) participant 353˙056.00
7    UNIVERSITE DE GENEVE CH (GENEVE) participant 265˙226.00
8    KHONDRION BV NL (BEUNINGEN) participant 255˙374.00
9    STICHTING KATHOLIEKE UNIVERSITEIT NL (NIJMEGEN) participant 255˙374.00
10    MEDICAL RESEARCH COUNCIL UK (SWINDON) participant 0.00

Map

 Project objective

Mitochondria are essential organelles found in every eukaryotic cell, required to convert food into usable energy. The mitochondrial oxidative phosphorylation (OXPHOS) system, which produces the majority of cellular energy in the form of ATP, is controlled by two distinct genomes: the nuclear and the mitochondrial genome (mtDNA). Mutations in mitochondrial genes encoded by either genome could cause diseases affecting OXPHOS system, called mitochondrial diseases, whose prevalence has been estimated to be ≈1:8500. Moreover, dysfunction of mitochondrial OXPHOS system has emerged as a key factor in a myriad of “common” diseases, including neurodegenerative and metabolic disorders like Parkinson’s and Alzheimer’s Disease, Type 2 Diabetes, and was linked to aging process. Despite all this, it is surprising that our understanding of the mechanisms governing the mitochondrial gene expression and its associated pathologies remain superficial and therapeutic interventions unexplored. The basic machineries for mtDNA replication, mtDNA transcription and mitochondrial translation are known, but the regulation of these processes in response to metabolic demands is poorly understood. The complex nature of mitochondrial gene expression that relies on two different genomes calls for a multidisciplinary approach where different teams of researchers join forces. Studies in this area are not only of basic scientific interest but may also provide new avenues towards treatment of mitochondrial dysfunction in a variety of human diseases. The key aim of the REMIX Network is combine the skills of European research groups to provide strategic training of the next generation of scientists through a programme that will progress in the elucidation of the molecular mechanisms and pathways that regulate mitochondrial gene expression.

 Deliverables

List of deliverables.
Advertising of positions and Recruitment of ESR Other 2020-02-20 11:08:47
Summer School Other 2020-02-20 11:08:47
Creation of Internal and External Web site Websites, patent fillings, videos etc. 2020-02-20 11:08:47
Recruitment of Project Manager Other 2020-02-20 11:08:47

Take a look to the deliverables list in detail:  detailed list of REMIX deliverables.

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The information about "REMIX" are provided by the European Opendata Portal: CORDIS opendata.

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