HALODRUGSYN SIGNED
Innovative Strategies towards Halogenated Organic Molecules: From Reaction Design to Application in Drug Synthesis
Total Cost €
0EC-Contrib. €
0Partnership
0Views
0HALODRUGSYN project word cloud
Explore the words cloud of the HALODRUGSYN project. It provides you a very rough idea of what is the project "HALODRUGSYN" about.
Project "HALODRUGSYN" data sheet
The following table provides information about the project.
| Coordinator |
UNIVERSITAET INNSBRUCK
Organization address contact info |
| Coordinator Country | Austria [AT] |
| Project website | https://www.uibk.ac.at/organic/magauer/index.html.en |
| Total cost | 1˙496˙664 € |
| EC max contribution | 1˙496˙664 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2016-STG |
| Funding Scheme | ERC-STG |
| Starting year | 2017 |
| Duration (year-month-day) | from 2017-02-01 to 2022-01-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | UNIVERSITAET INNSBRUCK | AT (INNSBRUCK) | coordinator | 1˙425˙986.00 |
| 2 | LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN | DE (MUENCHEN) | participant | 70˙677.00 |
Map
Project objective
Halogenated arenes and heteroarenes have become essential structural motifs of the pharmaceutical industry to create novel drugs against bacterial infections and cancer, and constitute highly valuable functional units in chemistry. Current methods for the installation of carbon-halogen bonds lack efficiency, selectivity, and practicability within the complex molecular setting of drug development processes. These restrictions prevent many potential drugs from being synthesized in a time- and cost-efficient manner. In this project, I aim to address these challenges by engineering a highly elaborated synthetic toolbox that is equipped with novel transformations of unprecedented efficiency, selectivity and practicability. I will apply these transformations to the construction of novel antibiotics against resistant strains and more efficient chemotherapeutics to combat cancer. The first objective is to establish innovative transformations that enable for the first time an efficient access to halogenated arenes. I will accomplish this goal by developing novel ring-expansion reactions and apply them to the first synthesis of the antibiotic salimabromide in order to address the acute problem of antibiotic resistance. Within the second part of this project, I will extend this unique synthetic platform to heteroarenes and establish a groundbreaking method based on carbon-fluorine bond activation. This will represent the first broadly applicable strategy to produce novel fluorinated heteroarene based anti-cancer drugs with unparalleled precision, efficiency and selectivity. Taken together, the realization of these strategies, all of which are unprecedented, provides for the first time a solution for the limitations associated with current methods. With my expertise in synthetic chemistry, which I have gained from my achievements in natural product synthesis, and an outstanding publication record in this research field, I am confident to accomplish these ambitious goals.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2019 |
Matthias Schmid, Adriana S. Grossmann, Peter Mayer, Thomas Müller, Thomas Magauer Ring-expansion approaches for the total synthesis of salimabromide published pages: 3195-3215, ISSN: 0040-4020, DOI: 10.1016/j.tet.2019.03.010 |
Tetrahedron 75/24 | 2019-08-29 |
| 2017 |
Raphael Wildermuth, Klaus Speck, Franz-Lucas Haut, Peter Mayer, Bianka Karge, Mark Brönstrup, Thomas Magauer A modular synthesis of tetracyclic meroterpenoid antibiotics published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-017-02061-7 |
Nature Communications 8/1 | 2019-06-13 |
| 2018 |
Johannes Feierfeil, Thomas Magauer De Novo Synthesis of Benzannelated Heterocycles published pages: 1455-1458, ISSN: 0947-6539, DOI: 10.1002/chem.201705662 |
Chemistry - A European Journal 24/6 | 2019-06-13 |
| 2018 |
Matthias Schmid, Adriana S. Grossmann, Klaus Wurst, Thomas Magauer Total Synthesis of Salimabromide: A Tetracyclic Polyketide from a Marine Myxobacterium published pages: , ISSN: 0002-7863, DOI: 10.1021/jacs.8b06228 |
Journal of the American Chemical Society | 2019-06-13 |
| 2017 |
Raphael Ernst Wildermuth, Tatjana Huber, Thomas Magauer 9-Membered Carbocycles: Strategies and Tactics for their Synthesis published pages: , ISSN: 0947-6539, DOI: 10.1002/chem.201705919 |
Chemistry - A European Journal | 2019-06-13 |
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "HALODRUGSYN" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "HALODRUGSYN" are provided by the European Opendata Portal: CORDIS opendata.