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HALODRUGSYN SIGNED

Innovative Strategies towards Halogenated Organic Molecules: From Reaction Design to Application in Drug Synthesis

Total Cost €

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EC-Contrib. €

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Partnership

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 HALODRUGSYN project word cloud

Explore the words cloud of the HALODRUGSYN project. It provides you a very rough idea of what is the project "HALODRUGSYN" about.

carbon    lack    valuable    time    groundbreaking    fluorine    create    selectivity    salimabromide    record    expertise    constitute    strains    natural    restrictions    elaborated    synthesis    activation    drugs    synthetic    chemistry    practicability    resistance    installation    goals    heteroarene    efficiency    synthesized    broadly    antibiotics    innovative    am    with    precision    efficient    structural    equipped    strategies    infections    chemotherapeutics    outstanding    expansion    heteroarenes    setting    solution    arenes    combat    engineering    bond    bonds    cancer    extend    publication    manner    units    functional    gained    applicable    molecular    limitations    acute    ring    platform    confident    transformations    first    bacterial    halogenated    halogen    resistant    strategy    pharmaceutical    construction    antibiotic    reactions    industry    unprecedented    provides    fluorinated    prevent    achievements    drug    unparalleled    toolbox    motifs    realization    anti   

Project "HALODRUGSYN" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAET INNSBRUCK 

Organization address
address: INNRAIN 52
city: INNSBRUCK
postcode: 6020
website: http://www.uibk.ac.at

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Project website https://www.uibk.ac.at/organic/magauer/index.html.en
 Total cost 1˙496˙664 €
 EC max contribution 1˙496˙664 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-02-01   to  2022-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAET INNSBRUCK AT (INNSBRUCK) coordinator 1˙425˙986.00
2    LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN DE (MUENCHEN) participant 70˙677.00

Map

 Project objective

Halogenated arenes and heteroarenes have become essential structural motifs of the pharmaceutical industry to create novel drugs against bacterial infections and cancer, and constitute highly valuable functional units in chemistry. Current methods for the installation of carbon-halogen bonds lack efficiency, selectivity, and practicability within the complex molecular setting of drug development processes. These restrictions prevent many potential drugs from being synthesized in a time- and cost-efficient manner. In this project, I aim to address these challenges by engineering a highly elaborated synthetic toolbox that is equipped with novel transformations of unprecedented efficiency, selectivity and practicability. I will apply these transformations to the construction of novel antibiotics against resistant strains and more efficient chemotherapeutics to combat cancer. The first objective is to establish innovative transformations that enable for the first time an efficient access to halogenated arenes. I will accomplish this goal by developing novel ring-expansion reactions and apply them to the first synthesis of the antibiotic salimabromide in order to address the acute problem of antibiotic resistance. Within the second part of this project, I will extend this unique synthetic platform to heteroarenes and establish a groundbreaking method based on carbon-fluorine bond activation. This will represent the first broadly applicable strategy to produce novel fluorinated heteroarene based anti-cancer drugs with unparalleled precision, efficiency and selectivity. Taken together, the realization of these strategies, all of which are unprecedented, provides for the first time a solution for the limitations associated with current methods. With my expertise in synthetic chemistry, which I have gained from my achievements in natural product synthesis, and an outstanding publication record in this research field, I am confident to accomplish these ambitious goals.

 Publications

year authors and title journal last update
List of publications.
2019 Matthias Schmid, Adriana S. Grossmann, Peter Mayer, Thomas Müller, Thomas Magauer
Ring-expansion approaches for the total synthesis of salimabromide
published pages: 3195-3215, ISSN: 0040-4020, DOI: 10.1016/j.tet.2019.03.010
Tetrahedron 75/24 2019-08-29
2017 Raphael Wildermuth, Klaus Speck, Franz-Lucas Haut, Peter Mayer, Bianka Karge, Mark Brönstrup, Thomas Magauer
A modular synthesis of tetracyclic meroterpenoid antibiotics
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-017-02061-7
Nature Communications 8/1 2019-06-13
2018 Johannes Feierfeil, Thomas Magauer
De Novo Synthesis of Benzannelated Heterocycles
published pages: 1455-1458, ISSN: 0947-6539, DOI: 10.1002/chem.201705662
Chemistry - A European Journal 24/6 2019-06-13
2018 Matthias Schmid, Adriana S. Grossmann, Klaus Wurst, Thomas Magauer
Total Synthesis of Salimabromide: A Tetracyclic Polyketide from a Marine Myxobacterium
published pages: , ISSN: 0002-7863, DOI: 10.1021/jacs.8b06228
Journal of the American Chemical Society 2019-06-13
2017 Raphael Ernst Wildermuth, Tatjana Huber, Thomas Magauer
9-Membered Carbocycles: Strategies and Tactics for their Synthesis
published pages: , ISSN: 0947-6539, DOI: 10.1002/chem.201705919
Chemistry - A European Journal 2019-06-13

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The information about "HALODRUGSYN" are provided by the European Opendata Portal: CORDIS opendata.

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