Explore the words cloud of the EndoSubvert project. It provides you a very rough idea of what is the project "EndoSubvert" about.
The following table provides information about the project.
|Coordinator Country||France [FR]|
|Total cost||2˙000˙000 €|
|EC max contribution||2˙000˙000 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2017-01-01 to 2021-12-31|
Take a look of project's partnership.
|1||INSTITUT PASTEUR||FR (PARIS CEDEX 15)||coordinator||2˙000˙000.00|
A common strategy of bacterial pathogens is active or passive uptake into host cells. There, they can localize within a bacterial containing vacuole (BCV) or access the host cytoplasm through BCV rupture. Hence, intracellular pathogens are often classified as vacuole-bound or cytoplasmic. Recently, this definition has been challenged by the discovery that many vacuole-bound pathogens, including Mycobacterium tuberculosis and Salmonella enterica, access the host cytoplasm, and by the insight that cytoplasmic bacteria, like Shigella flexneri or Listeria monocytogenes, do not always escape the BCV. Despite this increasing complexity, a precise understanding lacks for why and how a pathogen “chooses” between a BCV or the cytoplasm and yet this is very important: because of differential pathogen sensing in membrane-bound and cytoplasmic compartments, intracellular localization leads to induction of different host responses. Therefore, a comprehensive understanding of the processes controlling BCV integrity is not only essential, but can provide new therapeutic targets. Our previous research has implemented innovative fluorescence microscopy to track the invasion steps of pathogenic bacteria. We have further integrated a large-volume, correlative, light/electron microscopy (CLEM) workflow via focused ion beam scanning electron microscopy. This uncovered the subversion of host Rab cascades by Shigella to rupture its BCV. Starting with the Shigella model of epithelial cell invasion, we will delineate the precise molecular mechanisms controlling BCV integrity in different host cell types. We will analyze (i) the scaffolds of host pathways for membrane remodeling, (ii) their subversion by various pathogens, and (iii) their differential regulation depending on pathophysiological conditions. Together, this will allow development of novel, rational antimicrobial strategies and will yield fundamental insight into understudied cell biological mechanisms of membrane trafficking.
|year||authors and title||journal||last update|
Jakub Voznica, Christophe Gardella, Ilia Belotserkovsky, Alexandre Dufour, Jost Enninga, Virginie StÃ©venin
Identification of Parameters of Host Cell Vulnerability during Salmonella Infection by Quantitative Image Analysis and Modeling
published pages: , ISSN: 0019-9567, DOI: 10.1128/iai.00644-17
|Infection and Immunity 86/1||2019-11-07|
Chun Hui Sun, Benjamin Wacquier, Daniel I Aguilar, Nathalie Carayol, Kevin Denis, Sylviane Boucherie, Cesar Valenciaâ€Gallardo, Ceren Simsek, Christophe Erneux, Alexandre Lehman, Jost Enninga, Laurence Arbibe, Philippe Sansonetti, GeneviÃ¨ve Dupont, Laurent Combettes, Guy Tran Van Nhieu
The Shigella type III effector IpgD recodes Ca 2+ signals during invasion of epithelial cells
published pages: 2567-2580, ISSN: 0261-4189, DOI: 10.15252/embj.201696272
|The EMBO Journal 36/17||2019-11-07|
Jakub Voznica, Jost Enninga, Virginie StÃ©venin
High-throughput Microscopic Analysis of Salmonella Invasion of Host Cells
published pages: , ISSN: 2331-8325, DOI: 10.21769/bioprotoc.3017
Allon Weiner, Jost Enninga
The Pathogenâ€“Host Interface in Three Dimensions: Correlative FIB/SEM Applications
published pages: 426-439, ISSN: 0966-842X, DOI: 10.1016/j.tim.2018.11.011
|Trends in Microbiology 27/5||2019-11-07|
Magdalena Gil, Jost Enninga
Tracing a fat or sweet lifestyle - New insights on catabolic paths of intracellular Salmonella
published pages: 655-657, ISSN: 2150-5594, DOI: 10.1080/21505594.2017.1283466
Marine Oberkampf, Camille Guillerey, Juliette MouriÃ¨s, Pierre Rosenbaum, Catherine Fayolle, Alexandre Bobard, Ariel Savina, Eric Ogier-Denis, Jost Enninga, Sebastian Amigorena, Claude Leclerc, Gilles Dadaglio
Mitochondrial reactive oxygen species regulate the induction of CD8+ T cells by plasmacytoid dendritic cells
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-04686-8
|Nature Communications 9/1||2019-11-07|
Jennifer Fredlund, JosÃ© Carlos Santos, Virginie StÃ©venin, Allon Weiner, Patricia Latour-Lambert, Katya Rechav, Adeline Mallet, Jacomine Krijnse-Locker, Michael Elbaum, Jost Enninga
The entry of Salmonella in a distinct tight compartment revealed at high temporal and ultrastructural resolution
published pages: e12816, ISSN: 1462-5814, DOI: 10.1111/cmi.12816
|Cellular Microbiology 20/4||2019-11-07|
Sonja KÃ¼hn, Noelia Lopez-Montero, Yuen-Yan Chang, Anna Sartori-Rupp, Jost Enninga
Imaging macropinosomes during Shigella infections
published pages: 12-22, ISSN: 1046-2023, DOI: 10.1016/j.ymeth.2017.05.007
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