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IMAGO

Image Analysis Online Services for in-vitro experiments

Total Cost €

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EC-Contrib. €

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Partnership

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Project "IMAGO" data sheet

The following table provides information about the project.

Coordinator
UNIVERSIDAD DE ZARAGOZA 

Organization address
address: CALLE PEDRO CERBUNA 12
city: ZARAGOZA
postcode: 50009
website: www.unizar.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 150˙000 €
 EC max contribution 150˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-PoC
 Funding Scheme ERC-POC
 Starting year 2017
 Duration (year-month-day) from 2017-09-01   to  2019-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDAD DE ZARAGOZA ES (ZARAGOZA) coordinator 150˙000.00

Map

 Project objective

Image analysis has become a powerful tool in multiple biomedical applications, ranging from clinical cases to cellular experiments. The main purpose of IMAGO is to extract relevant information from image-based analysis to perform comparative studies in 3D cell cultures. Most of the cell-based experiments have been performed in 2D, but 3D conditions are biologically more relevant. IMAGO presents the development of a tool for image analysis focused on, but not limited to, the quantification of cell behavior under different conditions. Indeed, IMAGO goes further by providing, when applicable, an image-based finite element analysis (FEA). There exist different professional software solutions, but either they don’t allow post-processing data analyses or they require specialized formation and/or experience to be used efficiently. Furthermore, to the best of our knowledge, none of them permits the extraction of mechanical clues by means of a linked FEA. IMAGO brings together all these features and offers them through an online service that allows the user to customize his own analysis. During the ERC project INSILICO-CELL, we have developed our own software to quantitatively analyze specific in-vitro tests involving particle transport, cell migration, angiogenic sprouting, actin flow, dendritic protrusions and traction force microscopy among others. But, this software is flexible and can be adapted and extended to a wide variety of in-vitro experiments. Thus, it is worth exploring market opportunities to offer our knowledge and expertise to other laboratories, so they can process images from in-vitro tests and analyze their results, either by using an existing function in our software or by developing a new one on request. Therefore, the expected outcome of IMAGO is to demonstrate the potential feasibility of our software by offering our services to external laboratories, and developing a business strategy plan to eventually make our services available to the market.

 Publications

year authors and title journal last update
List of publications.
2018 N. Movilla, C. Borau, C. Valero, J.M. García-Aznar
Degradation of extracellular matrix regulates osteoblast migration: A microfluidic-based study
published pages: 10-17, ISSN: 8756-3282, DOI: 10.1016/j.bone.2017.10.025
Bone 107 2019-10-08
2018 Cristina Del Amo, Vanesa Olivares, Mar Cóndor, Alejandro Blanco, Jorge Santolaria, Jesús Asín, Carlos Borau, José Manuel García-Aznar
Matrix architecture plays a pivotal role in 3D osteoblast migration: The effect of interstitial fluid flow
published pages: 52-62, ISSN: 1751-6161, DOI: 10.1016/j.jmbbm.2018.04.007
Journal of the Mechanical Behavior of Biomedical Materials 83 2019-10-08
2018 J. Plou, Y. Juste-Lanas, V. Olivares, C. del Amo, C. Borau, J. M. García-Aznar
From individual to collective 3D cancer dissemination: roles of collagen concentration and TGF-β
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-30683-4
Scientific Reports 8/1 2019-10-08
2018 Sandra Pérez-Rodríguez, Esther Tomás-González, José García-Aznar
3D Cell Migration Studies for Chemotaxis on Microfluidic-Based Chips: A Comparison between Cardiac and Dermal Fibroblasts
published pages: 45, ISSN: 2306-5354, DOI: 10.3390/bioengineering5020045
Bioengineering 5/2 2019-09-06
2019 Vanesa Olivares, Mar Cóndor, Cristina Del Amo, Jesús Asín, Carlos Borau, José Manuel García-Aznar
Image-based characterization of 3D collagen networks and the effect of embedded cells
published pages: , ISSN: 1431-9276, DOI:
Microscopy and microanalysis Under review 2019-09-06
2017 Nieves Movilla, Clara Valero, Carlos Borau, JM. García-Aznar
Matrix degradation regulates osteoblast protrusion dynamics and individual migration
published pages: , ISSN: 1757-9708, DOI:
Integrative Biology Under review 2019-09-06
2019 Mar Cóndor, José Manuel García-Aznar
A recursive finite element-based approach/method for solving inverse problems in traction force microscopy
published pages: , ISSN: 0169-2607, DOI:
Computer Methods and Programs in Biomedicine Under review 2019-09-06
2019 Mar Cóndor, Christoph Mark, Richard C. Gerum, Nadine C. Grummel, Andreas Bauer, José M. García-Aznar, Ben Fabry
Breast Cancer Cells Adapt Contractile Forces to Overcome Steric Hindrance
published pages: 1305-1312, ISSN: 0006-3495, DOI: 10.1016/j.bpj.2019.02.029
Biophysical Journal 116/7 2019-09-06
2019 S. Hervas-Raluy, J. M. Garcia-Aznar, M. J. Gomez-Benito
Modelling actin polymerization: the effect on confined cell migration
published pages: , ISSN: 1617-7959, DOI: 10.1007/s10237-019-01136-2
Biomechanics and Modeling in Mechanobiology 2019-09-06

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