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MitoMethylome SIGNED

Mitochondrial methylation and its role in health and disease

Total Cost €


EC-Contrib. €






 MitoMethylome project word cloud

Explore the words cloud of the MitoMethylome project. It provides you a very rough idea of what is the project "MitoMethylome" about.

progression    physician    modifications    cell    scientific    fly    functions    pathology    mitochondrial    me    diverse    capacity    extensive    spectrometry    rare    fruit    disorders    sam    implicated    function    diseases    describes    co    opportunity    located    play    post    clear    inborn    metabolic    modern    advancements    plays    comprehensively    proteomic    approximately    mellitus    gene    30    genome    plan    sequencing    shown    central    dominant    ageing    specialities    mouse    model    event    molecular    unprecedented    bioenergetic    health    gives    levels    diabetes    donor    influence    group    methylome    disrupted    metabolites    patients    mass    regulation    methylation    mitochondria    dysfunction    adenosylmethionine    techniques    advocating    suffering    rest    nucleotide    clinical    metabolism    heart    cancer    relevance    errors    gained    neurodegeneration    exactly    translational    methyl    genetic    provides    cells    generate    synthesis    natural    methylations    downstream    disease    pool    epigenetic    models    cellular    perspective    possibility   

Project "MitoMethylome" data sheet

The following table provides information about the project.


Organization address
address: Nobels Vag 5
postcode: 17177

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 1˙499˙999 €
 EC max contribution 1˙499˙999 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-04-01   to  2022-03-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KAROLINSKA INSTITUTET SE (STOCKHOLM) coordinator 1˙499˙999.00


 Project objective

Mitochondria and mitochondrial function have gained increased attention within a wide range of clinical and scientific specialities, but exactly how mitochondria impact the rest of the cell is less well understood. Not only are mitochondria implicated in a range of rare genetic disorders, but dysfunction of mitochondria or reduced bioenergetic capacity has been associated with common diseases including cancer, heart failure, neurodegeneration and diabetes mellitus, as well as natural ageing. It is becoming increasingly clear that mitochondrial dysfunction is not only a downstream event in these conditions, but plays an important role in disease progression and pathology.

S-adenosylmethionine (SAM) is the dominant methyl group donor within our cells, required for a diverse set of post-translational modifications, nucleotide methylations or the synthesis of co-factors and metabolites. Mitochondria play an important part in SAM synthesis, and mitochondrial function has recently been shown to influence cellular methylation. Approximately 30% of the cellular SAM pool is located within mitochondria, advocating a central role for mitochondria in cellular methylation. The advancements in genome sequencing techniques, unprecedented depth of modern mass spectrometry analyses and our possibility to efficiently generate model systems, provides a rare opportunity to comprehensively study the role of both SAM and mitochondria in health and disease.

This project plan describes the genetic, molecular, metabolic and proteomic analysis of fruit fly and mouse models with mitochondrial dysfunction and disrupted intra-mitochondrial SAM levels to identify the mitochondrial methylome, its relevance towards other cellular functions and its impact on the epigenetic control of gene regulation. My extensive research on mitochondrial function, as well as working as a physician with patients suffering from inborn errors of metabolism gives me a unique perspective in this project.


year authors and title journal last update
List of publications.
2019 Florian A. Schober, Ilian Atanassov, David Moore, Anna Wedell, Christoph Freyer, Anna Wredenberg
Versatile proteome labelling in fruit flies with SILAF
published pages: , ISSN: , DOI: 10.1101/590315
BioRxiv 2019-11-07
2019 Aleksandra Pajak, Isabelle Laine, Paula Clemente, Najla El-Fissi, Florian A. Schober, Camilla Maffezzini, Javier Calvo-Garrido, Rolf Wibom, Roberta Filograna, Ashish Dhir, Anna Wedell, Christoph Freyer, Anna Wredenberg
Defects of mitochondrial RNA turnover lead to the accumulation of double-stranded RNA in vivo
published pages: e1008240, ISSN: 1553-7404, DOI: 10.1371/journal.pgen.1008240
PLOS Genetics 15/7 2019-11-07

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The information about "MITOMETHYLOME" are provided by the European Opendata Portal: CORDIS opendata.

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