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Learn2Walk SIGNED

Brain meets spine: the neural origin of toddler’s first steps

Total Cost €

0

EC-Contrib. €

0

Partnership

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 Learn2Walk project word cloud

Explore the words cloud of the Learn2Walk project. It provides you a very rough idea of what is the project "Learn2Walk" about.

spontaneous    impairments    ambition    moment    indicative    reflex    2011    neonate    palsy    techniques    profound    manifest    muscular    elucidate    emergence    unraveling    interplay    science    activation    independently    rehabilitation    basic    neural    hardwired    published    reorganization    overarching    toddlers    circuitry    answer    property    insights    walk    seminal    instinct    onset    motor    leap    me    character    small    provides    pioneering    coordinated    optimal    patterns    one    supplemented    learning    emergent    ones    locomotor    demonstrated    walking    muscle    start    realize    cortical    changing    latter    retained    opportunity    fundamental    strategy    cerebral    plan    identification    stepping    children    interaction    neuro    impairment    child    spontaneously    gradual    altered    underlying    giant    independent    takes    triggered    brain    combined    first    perform    born    normal    accompanying    cortico    questions   

Project "Learn2Walk" data sheet

The following table provides information about the project.

Coordinator
STICHTING VU 

Organization address
address: DE BOELELAAN 1105
city: AMSTERDAM
postcode: 1081 HV
website: www.vu.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 1˙331˙625 €
 EC max contribution 1˙331˙625 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-02-01   to  2022-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    STICHTING VU NL (AMSTERDAM) coordinator 1˙331˙625.00

Map

 Project objective

A child’s first steps may be small, but they are a giant leap for its development. Children have an instinct to walk from the moment they are born – a 'stepping reflex' hardwired in their neural circuitry – but it typically takes about one year before they can start walking independently. In a pioneering work published on Science in 2011, I demonstrated that the coordinated muscle activation in neonate stepping is described by two basic activation patterns that are retained throughout development, and supplemented by two new ones that be-come manifest in toddlers. These seminal findings triggered profound questions: Is the development of new patterns an emergent property, indicative of spontaneously changing cortico-muscular interaction? Does locomotor impairment change the spontaneous character of this emergent property into a gradual one? With the proposed research, I plan to answer these questions by studying the interplay between brain and muscular activity at the onset of independent walking. The overarching aim is to characterize the emergence of independent walking in typically developing children and in children affected by cerebral palsy, and to identify an optimal rehabilitation strategy to promote normal walking in the latter. I plan to perform a combined analysis of brain and muscular activity in typically developing children, unraveling the detailed processes underlying the learning of walking. I will then elucidate the reorganization of cortical and cortico-muscular activity accompanying the altered development of walking in children with cerebral palsy. Finally, I will apply these results to the identification of optimal rehabilitation techniques for children with cerebral palsy. It is my long-term ambition to exploit fundamental insights into neuro-motor control for promoting normal walking in children with locomotor impairments. The proposed project provides an exciting opportunity for me to realize this goal.

 Publications

year authors and title journal last update
List of publications.
2019 Adam T. C. Booth, Marjolein M. van der Krogt, Jaap Harlaar, Nadia Dominici, Annemieke I. Buizer
Muscle Synergies in Response to Biofeedback-Driven Gait Adaptations in Children With Cerebral Palsy
published pages: , ISSN: 1664-042X, DOI: 10.3389/fphys.2019.01208
Frontiers in Physiology 10 2019-11-13
2019 A. Bekius, C.S. Zandvoort, J.N. Kerkman, A. Daffertshofer, J. Harlaar A.I. Buizer, and N. Dominici
Poster Presentations
published pages: 62-82, ISSN: 0012-1622, DOI: 10.1111/dmcn.14245
Developmental Medicine & Child Neurology 61/S2 2019-09-20
2018 Bekius A, Kerkman JN, Zandvoort CS, Daffertshofer A, Buizer AI, Halaar J, Dominici N.
Oral Presentations
published pages: 4-27, ISSN: 0012-1622, DOI: 10.1111/dmcn.13789
Developmental Medicine & Child Neurology 60 2019-09-20
2019 Coen S. Zandvoort, Jaap H. van Dieën, Nadia Dominici, Andreas Daffertshofer
The human sensorimotor cortex fosters muscle synergies through cortico-synergy coherence
published pages: 30-37, ISSN: 1053-8119, DOI: 10.1016/j.neuroimage.2019.05.041
NeuroImage 199 2019-08-29

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The information about "LEARN2WALK" are provided by the European Opendata Portal: CORDIS opendata.

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