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Learn2Walk SIGNED

Brain meets spine: the neural origin of toddler’s first steps

Total Cost €

0

EC-Contrib. €

0

Partnership

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 Learn2Walk project word cloud

Explore the words cloud of the Learn2Walk project. It provides you a very rough idea of what is the project "Learn2Walk" about.

optimal    2011    first    perform    underlying    strategy    spontaneous    neuro    small    impairment    overarching    muscular    indicative    neural    patterns    triggered    altered    activation    plan    answer    manifest    start    born    onset    questions    toddlers    children    profound    unraveling    one    published    cerebral    realize    rehabilitation    leap    walking    latter    cortico    character    learning    pioneering    property    instinct    takes    provides    palsy    identification    insights    ambition    emergent    supplemented    ones    elucidate    independently    moment    changing    motor    demonstrated    emergence    cortical    interaction    walk    retained    normal    accompanying    reorganization    fundamental    techniques    impairments    stepping    circuitry    brain    hardwired    opportunity    gradual    combined    neonate    science    me    coordinated    reflex    independent    child    basic    giant    muscle    seminal    interplay    spontaneously    locomotor   

Project "Learn2Walk" data sheet

The following table provides information about the project.

Coordinator
STICHTING VU 

Organization address
address: DE BOELELAAN 1105
city: AMSTERDAM
postcode: 1081 HV
website: www.vu.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 1˙331˙625 €
 EC max contribution 1˙331˙625 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-02-01   to  2022-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    STICHTING VU NL (AMSTERDAM) coordinator 1˙331˙625.00

Map

 Project objective

A child’s first steps may be small, but they are a giant leap for its development. Children have an instinct to walk from the moment they are born – a 'stepping reflex' hardwired in their neural circuitry – but it typically takes about one year before they can start walking independently. In a pioneering work published on Science in 2011, I demonstrated that the coordinated muscle activation in neonate stepping is described by two basic activation patterns that are retained throughout development, and supplemented by two new ones that be-come manifest in toddlers. These seminal findings triggered profound questions: Is the development of new patterns an emergent property, indicative of spontaneously changing cortico-muscular interaction? Does locomotor impairment change the spontaneous character of this emergent property into a gradual one? With the proposed research, I plan to answer these questions by studying the interplay between brain and muscular activity at the onset of independent walking. The overarching aim is to characterize the emergence of independent walking in typically developing children and in children affected by cerebral palsy, and to identify an optimal rehabilitation strategy to promote normal walking in the latter. I plan to perform a combined analysis of brain and muscular activity in typically developing children, unraveling the detailed processes underlying the learning of walking. I will then elucidate the reorganization of cortical and cortico-muscular activity accompanying the altered development of walking in children with cerebral palsy. Finally, I will apply these results to the identification of optimal rehabilitation techniques for children with cerebral palsy. It is my long-term ambition to exploit fundamental insights into neuro-motor control for promoting normal walking in children with locomotor impairments. The proposed project provides an exciting opportunity for me to realize this goal.

 Publications

year authors and title journal last update
List of publications.
2019 Adam T. C. Booth, Marjolein M. van der Krogt, Jaap Harlaar, Nadia Dominici, Annemieke I. Buizer
Muscle Synergies in Response to Biofeedback-Driven Gait Adaptations in Children With Cerebral Palsy
published pages: , ISSN: 1664-042X, DOI: 10.3389/fphys.2019.01208
Frontiers in Physiology 10 2019-11-13
2019 A. Bekius, C.S. Zandvoort, J.N. Kerkman, A. Daffertshofer, J. Harlaar A.I. Buizer, and N. Dominici
Poster Presentations
published pages: 62-82, ISSN: 0012-1622, DOI: 10.1111/dmcn.14245
Developmental Medicine & Child Neurology 61/S2 2019-09-20
2018 Bekius A, Kerkman JN, Zandvoort CS, Daffertshofer A, Buizer AI, Halaar J, Dominici N.
Oral Presentations
published pages: 4-27, ISSN: 0012-1622, DOI: 10.1111/dmcn.13789
Developmental Medicine & Child Neurology 60 2019-09-20
2019 Coen S. Zandvoort, Jaap H. van Dieën, Nadia Dominici, Andreas Daffertshofer
The human sensorimotor cortex fosters muscle synergies through cortico-synergy coherence
published pages: 30-37, ISSN: 1053-8119, DOI: 10.1016/j.neuroimage.2019.05.041
NeuroImage 199 2019-08-29

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The information about "LEARN2WALK" are provided by the European Opendata Portal: CORDIS opendata.

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