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Learn2Walk SIGNED

Brain meets spine: the neural origin of toddler’s first steps

Total Cost €

0

EC-Contrib. €

0

Partnership

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 Learn2Walk project word cloud

Explore the words cloud of the Learn2Walk project. It provides you a very rough idea of what is the project "Learn2Walk" about.

cortical    questions    changing    demonstrated    me    children    interplay    one    opportunity    strategy    identification    indicative    activation    onset    coordinated    child    basic    overarching    published    interaction    provides    born    reorganization    muscle    property    plan    neural    takes    giant    first    impairments    perform    pioneering    character    impairment    profound    leap    accompanying    spontaneously    emergence    answer    retained    fundamental    ones    muscular    science    independent    small    locomotor    toddlers    instinct    learning    neuro    hardwired    triggered    ambition    walking    independently    walk    normal    palsy    spontaneous    motor    insights    supplemented    neonate    underlying    emergent    cortico    seminal    circuitry    manifest    techniques    2011    unraveling    patterns    rehabilitation    cerebral    optimal    start    realize    moment    reflex    altered    stepping    combined    gradual    elucidate    brain    latter   

Project "Learn2Walk" data sheet

The following table provides information about the project.

Coordinator
STICHTING VU 

Organization address
address: DE BOELELAAN 1105
city: AMSTERDAM
postcode: 1081 HV
website: www.vu.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 1˙331˙625 €
 EC max contribution 1˙331˙625 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-02-01   to  2022-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    STICHTING VU NL (AMSTERDAM) coordinator 1˙331˙625.00

Map

 Project objective

A child’s first steps may be small, but they are a giant leap for its development. Children have an instinct to walk from the moment they are born – a 'stepping reflex' hardwired in their neural circuitry – but it typically takes about one year before they can start walking independently. In a pioneering work published on Science in 2011, I demonstrated that the coordinated muscle activation in neonate stepping is described by two basic activation patterns that are retained throughout development, and supplemented by two new ones that be-come manifest in toddlers. These seminal findings triggered profound questions: Is the development of new patterns an emergent property, indicative of spontaneously changing cortico-muscular interaction? Does locomotor impairment change the spontaneous character of this emergent property into a gradual one? With the proposed research, I plan to answer these questions by studying the interplay between brain and muscular activity at the onset of independent walking. The overarching aim is to characterize the emergence of independent walking in typically developing children and in children affected by cerebral palsy, and to identify an optimal rehabilitation strategy to promote normal walking in the latter. I plan to perform a combined analysis of brain and muscular activity in typically developing children, unraveling the detailed processes underlying the learning of walking. I will then elucidate the reorganization of cortical and cortico-muscular activity accompanying the altered development of walking in children with cerebral palsy. Finally, I will apply these results to the identification of optimal rehabilitation techniques for children with cerebral palsy. It is my long-term ambition to exploit fundamental insights into neuro-motor control for promoting normal walking in children with locomotor impairments. The proposed project provides an exciting opportunity for me to realize this goal.

 Publications

year authors and title journal last update
List of publications.
2019 Adam T. C. Booth, Marjolein M. van der Krogt, Jaap Harlaar, Nadia Dominici, Annemieke I. Buizer
Muscle Synergies in Response to Biofeedback-Driven Gait Adaptations in Children With Cerebral Palsy
published pages: , ISSN: 1664-042X, DOI: 10.3389/fphys.2019.01208
Frontiers in Physiology 10 2019-11-13
2019 A. Bekius, C.S. Zandvoort, J.N. Kerkman, A. Daffertshofer, J. Harlaar A.I. Buizer, and N. Dominici
Poster Presentations
published pages: 62-82, ISSN: 0012-1622, DOI: 10.1111/dmcn.14245
Developmental Medicine & Child Neurology 61/S2 2019-09-20
2018 Bekius A, Kerkman JN, Zandvoort CS, Daffertshofer A, Buizer AI, Halaar J, Dominici N.
Oral Presentations
published pages: 4-27, ISSN: 0012-1622, DOI: 10.1111/dmcn.13789
Developmental Medicine & Child Neurology 60 2019-09-20
2019 Coen S. Zandvoort, Jaap H. van Dieën, Nadia Dominici, Andreas Daffertshofer
The human sensorimotor cortex fosters muscle synergies through cortico-synergy coherence
published pages: 30-37, ISSN: 1053-8119, DOI: 10.1016/j.neuroimage.2019.05.041
NeuroImage 199 2019-08-29

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The information about "LEARN2WALK" are provided by the European Opendata Portal: CORDIS opendata.

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