Explore the words cloud of the ChemEpigen project. It provides you a very rough idea of what is the project "ChemEpigen" about.
The following table provides information about the project.
|Coordinator Country||Denmark [DK]|
|Total cost||1˙500˙000 €|
|EC max contribution||1˙500˙000 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2017-04-01 to 2022-03-31|
Take a look of project's partnership.
|1||SYDDANSK UNIVERSITET||DK (ODENSE M)||coordinator||1˙266˙890.00|
|2||STICHTING KATHOLIEKE UNIVERSITEIT||NL (NIJMEGEN)||participant||233˙110.00|
The ultimate aim of this ERC project is to provide a comprehensive and complete understanding, at the atomic-level of sophistication, of genuinely important biomolecular recognition processes in epigenetics that play key roles in human health and disease. At the biochemical level, epigenetics refers to mechanisms, such as enzymatic modifications of DNA and posttranslational modifications of the associated histone proteins, that regulate the activity of human genes. The proposed work aims to address epigenetics using the physical-organic chemistry approach that enables the elucidation of the elemental processes with unprecedented molecular/atomic detail. The project will experimentally and computationally examine non-covalent interactions between three essential constituents of the epigenetic biomolecular system, namely epigenetic proteins, histones and water, at the level of short histone peptides, intact histone proteins, the nucleosome assembly and nucleosome arrays. Our programme, built on synergistic thermodynamic, structural and computational studies, aims to unravel i) the underlying chemical origin of methyllysine-containing histones in epigenetics, ii) the chemical basis for the recognition of methylarginine-containing histones in epigenetic processes, and iii) the role of unstructured histone tails in biomolecular recognition, which together form the three main structural elements found in the epigenetic framework. Results from this work will be important from both a fundamental molecular perspective as well as from the biomedical perspective, because proteins involved in epigenetic regulation processes are currently regarded as important targets for numerous therapeutic interventions, most notably for cancer treatment.
|year||authors and title||journal||last update|
Abbas H. K. Al Temimi, Paul B. White, Marcus J. M. Mulders, Nicole G. A. van der Linden, Richard H. Blaauw, Anita Wegert, Floris P. J. T. Rutjes, Jasmin MecinoviÄ‡
Methylation of geometrically constrained lysine analogues by histone lysine methyltransferases
published pages: 3039-3042, ISSN: 1359-7345, DOI: 10.1039/c9cc09098c
|Chemical Communications 56/20||2020-03-24|
Abbas H. K. Al Temimi, Vu Tran, Ruben S. Teeuwen, Arthur J. Altunc, Helene I. V. Amatdjais-Groenen, Paul B. White, Danny C. Lenstra, Giordano Proietti, Yali Wang, Anita Wegert, Richard H. Blaauw, Ping Qian, Wansheng Ren, Hong Guo, Jasmin MecinoviÄ‡
Examining sterically demanding lysine analogs for histone lysine methyltransferase catalysis
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-020-60337-3
|Scientific Reports 10/1||2020-03-24|
Abbas H. K. Al Temimi, Renate van der Wekken-de Bruijne, Giordano Proietti, Hong Guo, Ping Qian, Jasmin MecinoviÄ‡
Î³-Thialysine versus Lysine: An Insight into the Epigenetic Methylation of Histones
published pages: 1798-1804, ISSN: 1043-1802, DOI: 10.1021/acs.bioconjchem.9b00313
|Bioconjugate Chemistry 30/6||2020-02-19|
Bas J. G. E. Pieters, Jordi C. J. Hintzen, Yvonne Grobben, Abbas H. K. Al Temimi, Jos J. A. G. Kamps, Jasmin MecinoviÄ‡
Installation of Trimethyllysine Analogs on Intact Histones via Cysteine Alkylation
published pages: 952-958, ISSN: 1043-1802, DOI: 10.1021/acs.bioconjchem.9b00065
|Bioconjugate Chemistry 30/3||2020-02-19|
Abbas H. K. Al Temimi, Helene I. V. Amatdjais-Groenen, Y. Vijayendar Reddy, Richard H. Blaauw, Hong Guo, Ping Qian, Jasmin MecinoviÄ‡
The nucleophilic amino group of lysine is central for histone lysine methyltransferase catalysis
published pages: 112, ISSN: 2399-3669, DOI: 10.1038/s42004-019-0210-8
|Communications Chemistry 2/1||2020-02-19|
Roman Belle, Abbas H. K. Al Temimi, Kiran Kumar, Bas J. G. E. Pieters, Anthony Tumber, James E. Dunford, Catrine Johansson, Udo Oppermann, Tom Brown, Christopher J. Schofield, Richard J. Hopkinson, Robert S. Paton, Akane Kawamura, Jasmin MecinoviÄ‡
Investigating d -lysine stereochemistry for epigenetic methylation, demethylation and recognition
published pages: 13264-13267, ISSN: 1359-7345, DOI: 10.1039/c7cc08028j
|Chemical Communications 53/99||2020-02-19|
Abbas H. K. Al Temimi, Roman Belle, Kiran Kumar, Jordi Poater, Peter Betlem, Bas J. G. E. Pieters, Robert S. Paton, F. Matthias Bickelhaupt, Jasmin MecinoviÄ‡
Recognition of shorter and longer trimethyllysine analogues by epigenetic reader proteins
published pages: 2409-2412, ISSN: 1359-7345, DOI: 10.1039/c8cc01009a
|Chemical Communications 54/19||2020-02-19|
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