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Halo SIGNED

Development and Application of a New Class of Halogenated Reagents to Commercially Valuable Targets

Total Cost €

0

EC-Contrib. €

0

Partnership

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Project "Halo" data sheet

The following table provides information about the project.

Coordinator
ROYAL COLLEGE OF SURGEONS IN IRELAND 

Organization address
address: Saint Stephen's Green 123
city: DUBLIN
postcode: 2
website: www.rcsi.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 292˙500 €
 EC max contribution 292˙500 € (100%)
 Programme 1. H2020-EU.1.3.3. (Stimulating innovation by means of cross-fertilisation of knowledge)
 Code Call H2020-MSCA-RISE-2016
 Funding Scheme MSCA-RISE
 Starting year 2017
 Duration (year-month-day) from 2017-01-01   to  2020-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ROYAL COLLEGE OF SURGEONS IN IRELAND IE (DUBLIN) coordinator 130˙500.00
2    DESTINA GENOMICA ES (GRANADA) participant 81˙000.00
3    IRBM SCIENCE PARK SPA IT (POMEZIA RM) participant 81˙000.00
4    NAGOYA INSTITUTE OF TECHNOLOGY JP (NAGOYA) partner 0.00

Map

 Project objective

The aim of this project is to expand upon a newly discovered platform reaction by developing new routes to Active Pharmaceutical Ingredients (APIs) Tolterodine and Ezetimibe and other advanced intermediates for the manufacture of drugs (i.e. benzylic fluorides and alcohols). It is planned that this platform will serve to enhance the competitveness of the European pharmaceutical manufacturing industry as it continues to face increased competition from other economies

In order to achieve this aim we need to bring together expertise in (i) Organic Synthesis [Royal College of Surgeons in Ireland, “RCSI”] (ii) Enantioselective fluorination [Nagoya University Japan, “Nagoya”] (iii) Drug development and production [Integrated Research in Biotechnology & Medicine, “IRBM”]

To meet the aim we have divided the project into the following work packages: WP1: Development of a new synthesis of Tolterodine. WP2: Scale up of synthesis of Tolterodine. WP3: Development of a new synthesis of Ezetimibe. WP4: Scale up of synthesis of Ezetimibe. WP5: Exemplification of alkoxylation to prepare enantiopure benzylic alcohols API intermediates WP6: Preparation of benzylic fluorides WP7: Management, Training, Dissemination & Communication

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The information about "HALO" are provided by the European Opendata Portal: CORDIS opendata.

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