Opendata, web and dolomites

SCUBA CANCERS SIGNED

Finding the genetic causes of contagious metastases under the sea

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 SCUBA CANCERS project word cloud

Explore the words cloud of the SCUBA CANCERS project. It provides you a very rough idea of what is the project "SCUBA CANCERS" about.

offers    edule    evolve    coast    recurrently    transmitted    operate    unrelated    cockle    model    clonal    nearly    living    20    parasitic    cerastoderma    origins    environment    catalogue    depart    putative    genetic    validation    metastasis    polyphyletic    genome    ubiquity    figure    cockles    leukemia    individuals    contagious    drive    intends    opportunity    driver    atlantic    unexpected    ngs    identification    naturally    endless    alterations    gene    genes    transmissible    lineages    discovery    validated    somatic    drivers    mutational    provides    vitro    hosts    transmissibility    structure    transfer    insights    phylogenetic    biological    vivo    universal    genomic    prevalence    bivalves    occurring    mutated    first    origin    experimentation    cell    mechanisms    clonally    hn    gt    cancers    natural    approach    cells    illuminating    types    found    hemic    engineering    neoplasia    marine    cancer    western    source    editing   

Project "SCUBA CANCERS" data sheet

The following table provides information about the project.

Coordinator
UNIVERSIDAD DE SANTIAGO DE COMPOSTELA 

Organization address
address: COLEXIO DE SAN XEROME PRAZA DO OBRADOIRO S/N
city: SANTIAGO DE COMPOSTELA
postcode: 15782
website: http://www.usc.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Project website http://genomesdisease.tech/
 Total cost 1˙492˙500 €
 EC max contribution 1˙492˙500 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-01-01   to  2021-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDAD DE SANTIAGO DE COMPOSTELA ES (SANTIAGO DE COMPOSTELA) coordinator 989˙463.00
2    UNIVERSIDAD DE VIGO ES (VIGO PONTEVEDRA) participant 503˙036.00

Map

 Project objective

Clonally transmissible cancers are somatic cell lineages that are transmitted between individuals via the transfer of living cancer cells. There are only three known types of naturally occurring clonally transmissible cancers, one of which is a leukemia-like cancer found in marine bivalves, called hemic neoplasia (HN). HN in cockles Cerastoderma edule offers an unique opportunity, over the other naturally occurring transmissible cancers, for the discovery of the genetic drivers of cancer transmissibility because: (1) cockle HN has a polyphyletic origin, which allows the identification of recurrently mutated genes among different unrelated cockle HN lineages; (2) HN provides a reliable in vitro and in vivo model that could be used for driver gene discovery and validation by means of genetic engineering methods; (3) cockle HN represents a nearly endless source of biological resources for study and experimentation on the origins and development of natural clonally transmissible cancers, due to the ubiquity of cockles throughout the Western Atlantic coast of Europe and the high prevalence of HN (>20%). Using HN in cockles as a model for clonally transmissible cancers, this project intends to identify the genomic alterations and mutational processes that drive transmissible cancers to depart from their hosts and evolve as parasitic clonal lineages in the marine environment, for illuminating universal processes that make a cancer contagious, and to identify new/unexpected biological insights into the general mechanisms of cancer metastasis. We will first characterize the clonal structure of cockle transmissible cancers by phylogenetic approaches. Then, we will use NGS analysis to catalogue the somatic alterations that characterize different HN clonal lineages, figure out the mutational processes that operate in marine transmissible cancers, and identify the putative cancer genes that drive cancer transmissibility, which will be finally validated by genome editing approach

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "SCUBA CANCERS" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "SCUBA CANCERS" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

ZARAH (2020)

Women’s labour activism in Eastern Europe and transnationally, from the age of empires to the late 20th century

Read More  

CohoSing (2019)

Cohomology and Singularities

Read More  

SWIP (2019)

Extended short-wave infrared pulsed fibre laser

Read More