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SCUBA CANCERS SIGNED

Finding the genetic causes of contagious metastases under the sea

Total Cost €

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EC-Contrib. €

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Partnership

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 SCUBA CANCERS project word cloud

Explore the words cloud of the SCUBA CANCERS project. It provides you a very rough idea of what is the project "SCUBA CANCERS" about.

hemic    hosts    cell    vivo    recurrently    20    phylogenetic    hn    parasitic    marine    environment    lineages    metastasis    mutational    unexpected    biological    source    clonal    first    gt    transmissibility    occurring    genome    clonally    drive    cockle    depart    cancers    natural    bivalves    catalogue    engineering    editing    unrelated    living    gene    identification    universal    provides    drivers    prevalence    vitro    coast    found    figure    ubiquity    cells    opportunity    operate    somatic    cerastoderma    offers    validation    polyphyletic    genes    ngs    genetic    structure    naturally    model    western    atlantic    leukemia    alterations    illuminating    endless    transmissible    individuals    cancer    mutated    cockles    experimentation    insights    putative    transmitted    validated    neoplasia    nearly    approach    origin    types    contagious    origins    driver    genomic    edule    discovery    intends    evolve    mechanisms    transfer   

Project "SCUBA CANCERS" data sheet

The following table provides information about the project.

Coordinator
UNIVERSIDAD DE SANTIAGO DE COMPOSTELA 

Organization address
address: COLEXIO DE SAN XEROME PRAZA DO OBRADOIRO S/N
city: SANTIAGO DE COMPOSTELA
postcode: 15782
website: http://www.usc.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Project website http://genomesdisease.tech/
 Total cost 1˙492˙500 €
 EC max contribution 1˙492˙500 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-01-01   to  2021-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDAD DE SANTIAGO DE COMPOSTELA ES (SANTIAGO DE COMPOSTELA) coordinator 989˙463.00
2    UNIVERSIDAD DE VIGO ES (VIGO PONTEVEDRA) participant 503˙036.00

Map

 Project objective

Clonally transmissible cancers are somatic cell lineages that are transmitted between individuals via the transfer of living cancer cells. There are only three known types of naturally occurring clonally transmissible cancers, one of which is a leukemia-like cancer found in marine bivalves, called hemic neoplasia (HN). HN in cockles Cerastoderma edule offers an unique opportunity, over the other naturally occurring transmissible cancers, for the discovery of the genetic drivers of cancer transmissibility because: (1) cockle HN has a polyphyletic origin, which allows the identification of recurrently mutated genes among different unrelated cockle HN lineages; (2) HN provides a reliable in vitro and in vivo model that could be used for driver gene discovery and validation by means of genetic engineering methods; (3) cockle HN represents a nearly endless source of biological resources for study and experimentation on the origins and development of natural clonally transmissible cancers, due to the ubiquity of cockles throughout the Western Atlantic coast of Europe and the high prevalence of HN (>20%). Using HN in cockles as a model for clonally transmissible cancers, this project intends to identify the genomic alterations and mutational processes that drive transmissible cancers to depart from their hosts and evolve as parasitic clonal lineages in the marine environment, for illuminating universal processes that make a cancer contagious, and to identify new/unexpected biological insights into the general mechanisms of cancer metastasis. We will first characterize the clonal structure of cockle transmissible cancers by phylogenetic approaches. Then, we will use NGS analysis to catalogue the somatic alterations that characterize different HN clonal lineages, figure out the mutational processes that operate in marine transmissible cancers, and identify the putative cancer genes that drive cancer transmissibility, which will be finally validated by genome editing approach

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The information about "SCUBA CANCERS" are provided by the European Opendata Portal: CORDIS opendata.

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