Opendata, web and dolomites

SCUBA CANCERS SIGNED

Finding the genetic causes of contagious metastases under the sea

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 SCUBA CANCERS project word cloud

Explore the words cloud of the SCUBA CANCERS project. It provides you a very rough idea of what is the project "SCUBA CANCERS" about.

marine    polyphyletic    mechanisms    drivers    vivo    genetic    cancer    cockles    mutational    validation    first    hn    figure    intends    individuals    model    parasitic    clonal    ngs    transmitted    ubiquity    putative    vitro    structure    cancers    somatic    gt    evolve    opportunity    cerastoderma    nearly    hemic    hosts    mutated    metastasis    natural    alterations    lineages    approach    gene    experimentation    validated    naturally    edule    leukemia    bivalves    origin    atlantic    offers    transfer    phylogenetic    drive    living    engineering    unexpected    western    catalogue    genome    contagious    20    driver    illuminating    cell    depart    insights    coast    recurrently    environment    transmissible    cells    prevalence    source    editing    genomic    unrelated    universal    operate    endless    transmissibility    genes    origins    discovery    clonally    cockle    identification    types    provides    occurring    neoplasia    found    biological   

Project "SCUBA CANCERS" data sheet

The following table provides information about the project.

Coordinator
UNIVERSIDAD DE SANTIAGO DE COMPOSTELA 

Organization address
address: COLEXIO DE SAN XEROME PRAZA DO OBRADOIRO S/N
city: SANTIAGO DE COMPOSTELA
postcode: 15782
website: http://www.usc.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Project website http://genomesdisease.tech/
 Total cost 1˙492˙500 €
 EC max contribution 1˙492˙500 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-01-01   to  2021-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDAD DE SANTIAGO DE COMPOSTELA ES (SANTIAGO DE COMPOSTELA) coordinator 989˙463.00
2    UNIVERSIDAD DE VIGO ES (VIGO PONTEVEDRA) participant 503˙036.00

Map

 Project objective

Clonally transmissible cancers are somatic cell lineages that are transmitted between individuals via the transfer of living cancer cells. There are only three known types of naturally occurring clonally transmissible cancers, one of which is a leukemia-like cancer found in marine bivalves, called hemic neoplasia (HN). HN in cockles Cerastoderma edule offers an unique opportunity, over the other naturally occurring transmissible cancers, for the discovery of the genetic drivers of cancer transmissibility because: (1) cockle HN has a polyphyletic origin, which allows the identification of recurrently mutated genes among different unrelated cockle HN lineages; (2) HN provides a reliable in vitro and in vivo model that could be used for driver gene discovery and validation by means of genetic engineering methods; (3) cockle HN represents a nearly endless source of biological resources for study and experimentation on the origins and development of natural clonally transmissible cancers, due to the ubiquity of cockles throughout the Western Atlantic coast of Europe and the high prevalence of HN (>20%). Using HN in cockles as a model for clonally transmissible cancers, this project intends to identify the genomic alterations and mutational processes that drive transmissible cancers to depart from their hosts and evolve as parasitic clonal lineages in the marine environment, for illuminating universal processes that make a cancer contagious, and to identify new/unexpected biological insights into the general mechanisms of cancer metastasis. We will first characterize the clonal structure of cockle transmissible cancers by phylogenetic approaches. Then, we will use NGS analysis to catalogue the somatic alterations that characterize different HN clonal lineages, figure out the mutational processes that operate in marine transmissible cancers, and identify the putative cancer genes that drive cancer transmissibility, which will be finally validated by genome editing approach

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "SCUBA CANCERS" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "SCUBA CANCERS" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

PROGRESS (2019)

The Enemy of the Good: Towards a Theory of Moral Progress

Read More  

DISINTEGRATION (2019)

The Mass Politics of Disintegration

Read More  

3DPRINTEDOPTICS (2019)

3D printed micro- and nano-optics for future integrated vision and endoscopy systems

Read More