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NOGOPROOF

Towards clinical trials for a novel treatment for stroke

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 NOGOPROOF project word cloud

Explore the words cloud of the NOGOPROOF project. It provides you a very rough idea of what is the project "NOGOPROOF" about.

interrupted    neurite    functional    expressed    opportunity    injuries    discovered    exists    treatment    unmet    medical    circuit    hardware    disabled    primate    models    central    establishing    translatable    basis    nogo    regeneration    paradigm    health    full    care    preclinical    despite    cord    axonal    plastic    induce    substantial    fiber    patients    group    stroke    phenomenon    almost    human    restricted    transition    antibodies    form    recovery    protein    market    tracts    proof    anti    rehabilitation    rodent    directed    injury    disability    strategy    membrane    therapies    molecular    degree    inhibitory    spinal    followed    western    mediate    nogorise    mammalian    accordingly    adult    nerve    impediments    world    cns    nervous    half    antibody    critical    shown    rearrangements    administration    rats    acute    data    myelin    therapy    improvements    clinical    extremely    strokes    rehabilitative    intensive    erc    proteins    training    business    grant   

Project "NOGOPROOF" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAT ZURICH 

Organization address
address: RAMISTRASSE 71
city: ZURICH
postcode: 8006
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 150˙000 €
 EC max contribution 150˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-PoC
 Funding Scheme ERC-POC
 Starting year 2017
 Duration (year-month-day) from 2017-03-01   to  2018-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAT ZURICH CH (ZURICH) coordinator 150˙000.00

Map

 Project objective

Stroke is the leading cause of adult disability and represents a major health problem in the EU and the Western world. Despite available acute care treatment and rehabilitation therapies, more than half of the patients remain disabled and there is a large unmet medical need accordingly. Regeneration of interrupted nerve fiber tracts and plastic “hardware” changes in the adult mammalian central nervous system are extremely restricted, a phenomenon which represents a key reason for the low degree of recovery following CNS injuries including stroke. The molecular impediments that form the basis of this phenomenon are neurite growth inhibitory proteins expressed in central nervous system myelin, in particular the membrane protein Nogo-A which was discovered by our group. Importantly, antibodies directed against Nogo-A have been shown to induce axonal regeneration, enhance plastic circuit rearrangements and mediate significant improvements in functional recovery in rodent and non-human primate models of stroke and spinal cord injury. As recently shown in the ERC advanced grant supported the project ‘Nogorise’, almost full functional recovery was observed in rats with large strokes when anti-Nogo-A antibody treatment was followed by intensive rehabilitative training. As currently no therapy for human stroke patients beyond acute care and rehabilitation exists, there is a substantial market opportunity for the anti- Nogo-A therapy. The proposed activities within the present project aim at further establishing preclinical proof-of-concept for an anti-Nogo-A administration paradigm translatable to human stroke patients and development of human antibodies targeting Nogo-A. The expected data package will allow the critical transition from preclinical to clinical development and support the development of a comprehensive business strategy.

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