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Towards clinical trials for a novel treatment for stroke

Total Cost €


EC-Contrib. €






 NOGOPROOF project word cloud

Explore the words cloud of the NOGOPROOF project. It provides you a very rough idea of what is the project "NOGOPROOF" about.

improvements    administration    erc    molecular    spinal    directed    nervous    membrane    human    shown    disability    injury    translatable    substantial    form    market    unmet    tracts    paradigm    accordingly    health    strokes    phenomenon    half    basis    world    almost    antibody    antibodies    rehabilitation    injuries    group    functional    clinical    establishing    mammalian    hardware    acute    full    mediate    degree    treatment    circuit    plastic    protein    nogorise    axonal    rodent    neurite    expressed    restricted    nogo    transition    disabled    proof    therapies    stroke    therapy    western    induce    training    primate    cord    opportunity    proteins    fiber    data    interrupted    cns    anti    myelin    patients    recovery    extremely    rats    discovered    central    rearrangements    business    preclinical    adult    models    medical    inhibitory    grant    critical    exists    nerve    followed    care    strategy    despite    impediments    rehabilitative    intensive    regeneration   

Project "NOGOPROOF" data sheet

The following table provides information about the project.


Organization address
address: RAMISTRASSE 71
city: ZURICH
postcode: 8006
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 150˙000 €
 EC max contribution 150˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-PoC
 Funding Scheme ERC-POC
 Starting year 2017
 Duration (year-month-day) from 2017-03-01   to  2018-08-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAT ZURICH CH (ZURICH) coordinator 150˙000.00


 Project objective

Stroke is the leading cause of adult disability and represents a major health problem in the EU and the Western world. Despite available acute care treatment and rehabilitation therapies, more than half of the patients remain disabled and there is a large unmet medical need accordingly. Regeneration of interrupted nerve fiber tracts and plastic “hardware” changes in the adult mammalian central nervous system are extremely restricted, a phenomenon which represents a key reason for the low degree of recovery following CNS injuries including stroke. The molecular impediments that form the basis of this phenomenon are neurite growth inhibitory proteins expressed in central nervous system myelin, in particular the membrane protein Nogo-A which was discovered by our group. Importantly, antibodies directed against Nogo-A have been shown to induce axonal regeneration, enhance plastic circuit rearrangements and mediate significant improvements in functional recovery in rodent and non-human primate models of stroke and spinal cord injury. As recently shown in the ERC advanced grant supported the project ‘Nogorise’, almost full functional recovery was observed in rats with large strokes when anti-Nogo-A antibody treatment was followed by intensive rehabilitative training. As currently no therapy for human stroke patients beyond acute care and rehabilitation exists, there is a substantial market opportunity for the anti- Nogo-A therapy. The proposed activities within the present project aim at further establishing preclinical proof-of-concept for an anti-Nogo-A administration paradigm translatable to human stroke patients and development of human antibodies targeting Nogo-A. The expected data package will allow the critical transition from preclinical to clinical development and support the development of a comprehensive business strategy.

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The information about "NOGOPROOF" are provided by the European Opendata Portal: CORDIS opendata.

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