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NOGOPROOF

Towards clinical trials for a novel treatment for stroke

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 NOGOPROOF project word cloud

Explore the words cloud of the NOGOPROOF project. It provides you a very rough idea of what is the project "NOGOPROOF" about.

rats    strategy    membrane    accordingly    intensive    adult    transition    human    phenomenon    induce    circuit    models    form    restricted    rearrangements    basis    tracts    degree    molecular    cord    regeneration    plastic    medical    cns    mammalian    acute    primate    impediments    protein    paradigm    nogo    administration    hardware    axonal    western    inhibitory    world    rodent    myelin    neurite    antibodies    market    directed    critical    extremely    disability    functional    anti    nervous    establishing    despite    rehabilitation    recovery    exists    data    patients    interrupted    proof    preclinical    therapies    strokes    spinal    shown    discovered    antibody    business    stroke    unmet    training    almost    nogorise    opportunity    disabled    improvements    central    injury    rehabilitative    full    care    expressed    health    clinical    substantial    injuries    erc    mediate    followed    treatment    fiber    half    grant    group    nerve    proteins    therapy    translatable   

Project "NOGOPROOF" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAT ZURICH 

Organization address
address: RAMISTRASSE 71
city: ZURICH
postcode: 8006
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 150˙000 €
 EC max contribution 150˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-PoC
 Funding Scheme ERC-POC
 Starting year 2017
 Duration (year-month-day) from 2017-03-01   to  2018-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAT ZURICH CH (ZURICH) coordinator 150˙000.00

Map

 Project objective

Stroke is the leading cause of adult disability and represents a major health problem in the EU and the Western world. Despite available acute care treatment and rehabilitation therapies, more than half of the patients remain disabled and there is a large unmet medical need accordingly. Regeneration of interrupted nerve fiber tracts and plastic “hardware” changes in the adult mammalian central nervous system are extremely restricted, a phenomenon which represents a key reason for the low degree of recovery following CNS injuries including stroke. The molecular impediments that form the basis of this phenomenon are neurite growth inhibitory proteins expressed in central nervous system myelin, in particular the membrane protein Nogo-A which was discovered by our group. Importantly, antibodies directed against Nogo-A have been shown to induce axonal regeneration, enhance plastic circuit rearrangements and mediate significant improvements in functional recovery in rodent and non-human primate models of stroke and spinal cord injury. As recently shown in the ERC advanced grant supported the project ‘Nogorise’, almost full functional recovery was observed in rats with large strokes when anti-Nogo-A antibody treatment was followed by intensive rehabilitative training. As currently no therapy for human stroke patients beyond acute care and rehabilitation exists, there is a substantial market opportunity for the anti- Nogo-A therapy. The proposed activities within the present project aim at further establishing preclinical proof-of-concept for an anti-Nogo-A administration paradigm translatable to human stroke patients and development of human antibodies targeting Nogo-A. The expected data package will allow the critical transition from preclinical to clinical development and support the development of a comprehensive business strategy.

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