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BINAMA TERMINATED

Biomimicking nanostructured materials via intra(inter)molecular folding of sequence-controlled polymers

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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Project "BINAMA" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF WARWICK 

Organization address
address: Kirby Corner Road - University House
city: COVENTRY
postcode: CV4 8UW
website: www.warwick.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
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 Coordinator Country United Kingdom [UK]
 Project website https://warwick.ac.uk/fac/sci/chemistry/research/haddleton/haddletongroup
 Total cost 211˙825 €
 EC max contribution 211˙825 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-GF
 Starting year 2017
 Duration (year-month-day) from 2017-01-20   to  2019-07-19

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF WARWICK UK (COVENTRY) coordinator 211˙825.00
2    THE REGENTS OF THE UNIVERSITY OF CALIFORNIA US (OAKLAND CA) partner 0.00

Map

 Project objective

Nature employs various polymerization processes (e.g. DNA replication, transcription and translation of proteins) in order to synthesize biopolymers such as DNA and proteins with controlled sequences and configurations. Such remarkable and complicated structures can fold into precise nanostructures via intramolecular and intermolecular interactions and thus replicating these domains via synthetic polymers has recently attracted considerable interest. The goal of BINAMA is to synthesize biomimicking nanostructure materials via intramolecular folding of sequence-controlled polymers in the presence of a “real” catalyst/chaperone, thus mimicking the intracellular environment. For the first part of the project, the sequence of functional monomers will be controlled utilizing controlled living radical polymerization methods. Subsequently, the incorporation of these monomers will induce hydrogen bonding, hydrophobic/hydrophobic, pi-pi, charge and disulphide interactions typically employed by proteins in order to facilitate the controlled folding of the polymer chains, adopting natural motifs and patterns. The ability to mimic these perfectly defined sequence-controlled polymers (e.g. DNA and proteins) via synthetic polymer chemistry will pave the way for synthetic bioanalogues and could also enhance their functions and properties.

 Publications

year authors and title journal last update
List of publications.
2019 Arkadios Marathianos, Evelina Liarou, Athina Anastasaki, Richard Whitfield, Matthew Laurel, Alan M. Wemyss, David M. Haddleton
Photo-induced copper-RDRP in continuous flow without external deoxygenation
published pages: 4402-4406, ISSN: 1759-9954, DOI: 10.1039/c9py00945k
Polymer Chemistry 10/32 2019-10-28
2018 Richard Whitfield, Athina Anastasaki, Glen R. Jones, David M. Haddleton
Cu(0)-RDRP of styrene: balancing initiator efficiency and dispersity
published pages: 4395-4403, ISSN: 1759-9954, DOI: 10.1039/c8py00814k
Polymer Chemistry 9/34 2019-06-06
2018 Evelina Liarou, Richard Whitfield, Athina Anastasaki, Nikolaos G. Engelis, Glen R. Jones, Kelly Velonia, David M. Haddleton
Copper-Mediated Polymerization without External Deoxygenation or Oxygen Scavengers
published pages: 8998-9002, ISSN: 1433-7851, DOI: 10.1002/anie.201804205
Angewandte Chemie International Edition 57/29 2019-06-06
2018 Glen R. Jones, Athina Anastasaki, Richard Whitfield, Nikolaos Engelis, Evelina Liarou, David M. Haddleton
Copper-Mediated Reversible Deactivation Radical Polymerization in Aqueous Media
published pages: 10468-10482, ISSN: 1433-7851, DOI: 10.1002/anie.201802091
Angewandte Chemie International Edition 57/33 2019-06-06
2018 Richard Whitfield, Athina Anastasaki, Nghia P. Truong, Alexander B. Cook, Marta Omedes-Pujol, Vanessa Loczenski Rose, Tuan A. H. Nguyen, James A. Burns, Sébastien Perrier, Thomas P. Davis, David M. Haddleton
Efficient Binding, Protection, and Self-Release of dsRNA in Soil by Linear and Star Cationic Polymers
published pages: 909-915, ISSN: 2161-1653, DOI: 10.1021/acsmacrolett.8b00420
ACS Macro Letters 7/8 2019-06-06
2018 Nikolaos G. Engelis, Athina Anastasaki, Richard Whitfield, Glen R. Jones, Evelina Liarou, Vasiliki Nikolaou, Gabit Nurumbetov, David M. Haddleton
Sequence-Controlled Methacrylic Multiblock Copolymers: Expanding the Scope of Sulfur-Free RAFT
published pages: 336-342, ISSN: 0024-9297, DOI: 10.1021/acs.macromol.7b01987
Macromolecules 51/2 2019-06-06
2017 Athina Anastasaki, Bernd Oschmann, Johannes Willenbacher, Anna Melker, Martin H. C. Van Son, Nghia P. Truong, Morgan W. Schulze, Emre H. Discekici, Alaina J. McGrath, Thomas P. Davis, Christopher M. Bates, Craig J. Hawker
One-Pot Synthesis of ABCDE Multiblock Copolymers with Hydrophobic, Hydrophilic, and Semi-Fluorinated Segments
published pages: 14483-14487, ISSN: 1433-7851, DOI: 10.1002/anie.201707646
Angewandte Chemie International Edition 56/46 2019-02-28

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