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GLYCONOISE SIGNED

Emergent properties of cell surface glycosylation in cell-cell communication

Total Cost €

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EC-Contrib. €

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Partnership

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 GLYCONOISE project word cloud

Explore the words cloud of the GLYCONOISE project. It provides you a very rough idea of what is the project "GLYCONOISE" about.

surface    glycomes    stems    noise    sbquo    biology    interaction    codes    fundamental    emerge    poorly    reconstructed    immunological    population    constants    identical    tolerate    rate    lectin    messages    formed    adapting    influencing    dimensional    receiver    advancements    redundancy    lost    single    techniques    combining    communication    simplified    cytometry    messaging    replacing    binding    employ    biophysics    enabled    cellular    model    glycosylated    questions    living    trigger    genetically    software    biophysical    message    glycans    composition    gives    mixtures    receptors    robustness    glycobioinformatics    ultra    decoding    flow    disturb    interactions    biological    dense    vary    compositions    sciences    first    instrumentation    expressing    structure    microparticles    reveals    transmitter    accessible    differentiation    cells    competitive    function    biopolymers    expanded    data    determined    cell    covered    experimental    matrix    quantify    glycan    provides   

Project "GLYCONOISE" data sheet

The following table provides information about the project.

Coordinator
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV 

Organization address
address: HOFGARTENSTRASSE 8
city: Munich
postcode: 80539
website: www.mpg.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙499˙813 €
 EC max contribution 1˙499˙813 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-02-01   to  2022-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (Munich) coordinator 1˙499˙813.00

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 Project objective

The surface of every living cell is covered with a dense matrix of glycans. Its particular composition and structure codes important messages in cell-cell communication, influencing development, differentiation, and immunological processes. The matrix is formed by highly complex biopolymers whose compositions vary from cell to cell, even between genetically identical cells. This gives rise to population noise in cell-cell communication. A second level of noise stems from glycans present on the same cell that disturb the decoding of the message by glycans binding receptors through competitive binding. Glycan-based communication is characterized by a high redundancy of both glycans and their receptors. Thus, noise and redundancy emerge as key properties of glycan-based cell-cell communication, but their extent and function are poorly understood.

By adapting a transmitter-receiver model from communication sciences and combining it with state-of-the-art experimental techniques from biophysics and cell biology, we will address two fundamental questions: What is the role of the redundancy in glycan-based communication? How much ‚noise’ can it tolerate, before the message is lost?

To do so, we first establish a simplified model system for glycan-based communication. Biophysical rate constants are determined for lectin-glycan interactions and expanded to glycosylated microparticles that trigger a biological response in lectin expressing receiver cells. Next, single cell glycomes are reconstructed from ultra-high dimensional flow cytometry data using lectin mixtures enabled by recent advancements in instrumentation and glycobioinformatics software. Glycomes accessible on single cell level allow replacing the microparticles with transmitter cells and employ a cell-cell interaction model. Our transmitter-receiver model is used to quantify the noise and reveals how redundancy provides robustness of messaging by cell surface glycans in cellular communication.

 Publications

year authors and title journal last update
List of publications.
2019 Jessica Schulze, Mareike Rentzsch, Dongyoon Kim, Lydia Bellmann, Patrizia Stoitzner, Christoph Rademacher
A Liposomal Platform for Delivery of a Protein Antigen to Langerin-Expressing Cells
published pages: 2576-2580, ISSN: 0006-2960, DOI: 10.1021/acs.biochem.9b00402
Biochemistry 58/21 2019-10-03

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