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EcoLipid SIGNED

Ecophysiology of membrane lipid remodelling in marine bacteria

Total Cost €

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EC-Contrib. €

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Partnership

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 EcoLipid project word cloud

Explore the words cloud of the EcoLipid project. It provides you a very rough idea of what is the project "EcoLipid" about.

organisms    coli    escherichia    functioning    structural    insights    deficiency    limitation    betaine    predominantly    found    stress    cell    occurs    offers    composition    glycolipids    hypothesize    biology    oligotrophic    profound    competitive    omics    advantage    ornithine    lack    trade    physiological    cycles    adapt    environment    cycling    phosphatidylethanolamine    microbial    sar11    myself    sulfur    fitness    membranes    membrane    basis    significantly    unknown    biotic    stresses    heterotrophs    phytoplankton    reveal    phosphatidylglycerol    marine    clades    deal    waters    numerically    lipids    abundant    phospholipids    roseobacter    demonstrated    molecular    containing    physiology    phosphorus    remodeling    bacteria    cells    capacity    cosmopolitan    abiotic    players    restricting    bacterial    envelope    form    whereby    biogeochemical    lipid    remodelling    knock    environments    ecologically    nutrient    offs    thought    ecological    synthesis    substitute    heterotrophic    uses    sulfolipids    until    ecophysiology    free   

Project "EcoLipid" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF WARWICK 

Organization address
address: Kirby Corner Road - University House
city: COVENTRY
postcode: CV4 8UW
website: www.warwick.ac.uk

contact info
title: n.a.
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surname: n.a.
function: n.a.
email: n.a.
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 Coordinator Country United Kingdom [UK]
 Project website https://warwick.ac.uk/fac/sci/lifesci/research/ychen/5
 Total cost 1˙965˙113 €
 EC max contribution 1˙965˙113 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-COG
 Funding Scheme ERC-COG
 Starting year 2017
 Duration (year-month-day) from 2017-04-01   to  2022-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF WARWICK UK (COVENTRY) coordinator 1˙965˙113.00

Map

 Project objective

'Membrane lipids form the structural basis of all cells. In bacteria Escherichia coli uses predominantly phosphorus-containing lipids (phospholipids) in its cell envelope, including phosphatidylethanolamine and phosphatidylglycerol. However, beyond E. coli a range of lipids are found in bacterial membranes, including phospholipids as well as phosphorus (P)-free lipids such as betaine lipids, ornithine lipids, sulfolipids and glycolipids. In the marine environment, it is well established that P availability significantly affects lipid composition in the phytoplankton, whereby non-P sulfur-containing lipids are used to substitute phospholipids in response to P stress. This remodeling offers a significant competitive advantage for these organisms, allowing them to adapt to oligotrophic environments low in P. Until very recently, abundant marine heterotrophic bacteria were thought to lack the capacity for lipid remodelling in response to P deficiency. However, recent work by myself and others has now demonstrated that lipid remodelling occurs in many ecologically important marine heterotrophs, such as the SAR11 and Roseobacter clades, which are not only numerically abundant in marine waters but also crucial players in the biogeochemical cycling of key elements. However, the ecological and physiological consequences of lipid remodeling, in response to nutrient limitation, remain unknown. This is important because I hypothesize that lipid remodeling has important knock-on effects restricting the ability of marine bacteria to deal with both abiotic and biotic stresses, which has profound consequences for the functioning of major biogeochemical cycles. Here I aim to use a synthesis of molecular biology, microbial physiology, and 'omics' approaches to reveal the fitness trade-offs of lipid remodelling in cosmopolitan marine heterotrophic bacteria, providing novel insights into the ecophysiology of lipid remodelling and its consequences for marine nutrient cycling.'

 Publications

year authors and title journal last update
List of publications.
2018 Alastair F. Smith, Branko Rihtman, Rachel Stirrup, Eleonora Silvano, Michaela A. Mausz, David J. Scanlan, Yin Chen
Elucidation of glutamine lipid biosynthesis in marine bacteria reveals its importance under phosphorus deplete growth in Rhodobacteraceae
published pages: , ISSN: 1751-7362, DOI: 10.1038/s41396-018-0249-z
The ISME Journal 2019-04-04

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