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Anticancer-PAM

Anticancer activity of plasma activated medium and its underlying mechanisms: Combined experimental and computational study

Total Cost €

0

EC-Contrib. €

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Partnership

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Project "Anticancer-PAM" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITEIT ANTWERPEN 

Organization address
address: PRINSSTRAAT 13
city: ANTWERPEN
postcode: 2000
website: www.ua.ac.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Project website http://nano.uantwerpen.be/nanorefs/search.php
 Total cost 160˙800 €
 EC max contribution 160˙800 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-09-01   to  2019-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITEIT ANTWERPEN BE (ANTWERPEN) coordinator 160˙800.00

Map

 Project objective

Cold atmospheric plasma (CAP) is gaining increasing interest for cancer treatment, although the application is still in its early stages. Besides direct CAP treatment of cancer cells, plasma can also be used to activate a liquid medium, which seems to have similar anti-cancer effects as the plasma itself. This so-called plasma activated medium (PAM) is very promising for cancer treatment, as it can be more generally used, e.g., it might be directly injected into tissue of patients. However, the anticancer potential of PAM is not yet fully understood. This is exactly the focus of this project. We will measure the reactive oxygen and nitrogen species (RONS) concentrations in PAM, and also calculate them with a model for plasma-liquid interaction. In addition, we will study the effect of PAM on a catalase model protein by experiments, and perform atomic scale simulations for the interaction of RONS with this protein, to better understand the effect of PAM on cancer cells, because catalase aids cancer cells in overcoming oxidative stress created by PAM.

 Publications

year authors and title journal last update
List of publications.
2018 Naresh Kumar, Pankaj Attri, Sylvia Dewilde, Annemie Bogaerts
Inactivation of human pancreatic ductal adenocarcinoma with atmospheric plasma treated media and water: a comparative study
published pages: 255401, ISSN: 0022-3727, DOI: 10.1088/1361-6463/aac571
Journal of Physics D: Applied Physics 51/25 2020-03-11
2018 Naresh Kumar, Priyanka Shaw, Jamoliddin Razzokov, Maksudbek Yusupov, Pankaj Attri, Han Sup Uhm, Eun Ha Choi, Annemie Bogaerts
Enhancement of cellular glucose uptake by reactive species: a promising approach for diabetes therapy
published pages: 9887-9894, ISSN: 2046-2069, DOI: 10.1039/c7ra13389h
RSC Advances 8/18 2020-03-11
2019 Bhagirath Ghimire, Endre J. Szili, Pradeep Lamichhane, Robert D. Short, Jun Sup Lim, Pankaj Attri, Kai Masur, Klaus-Dieter Weltmann, Sung-Ha Hong, Eun Ha Choi
The role of UV photolysis and molecular transport in the generation of reactive species in a tissue model with a cold atmospheric pressure plasma jet
published pages: 93701, ISSN: 0003-6951, DOI: 10.1063/1.5086522
Applied Physics Letters 114/9 2020-03-11
2019 Pankaj Attri, Annemie Bogaerts
Perspectives of Plasma-treated Solutions as Anticancer Drugs
published pages: 436-438, ISSN: 1871-5206, DOI: 10.2174/187152061904190521102345
Anti-Cancer Agents in Medicinal Chemistry 19/4 2020-03-11

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