GlycoModels
3D glyco-engineered models to address the role of glycosylation in gastric cancer clinical management
Total Cost €
0EC-Contrib. €
0Partnership
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Project "GlycoModels" data sheet
The following table provides information about the project.
| Coordinator |
IPATIMUP - INSTITUTO DE PATOLOGIA E IMUNOLOGIA MOLECULAR DA UNIVERSIDADE DO PORTO PCUP
Organization address contact info |
| Coordinator Country | Portugal [PT] |
| Project website | http://portal.i3s.up.pt/docs/mbalmana/1560417923482MBalmanawebsitereportpdf.pdf |
| Total cost | 148˙635 € |
| EC max contribution | 148˙635 € (100%) |
| Programme |
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility) |
| Code Call | H2020-MSCA-IF-2016 |
| Funding Scheme | MSCA-IF-EF-ST |
| Starting year | 2017 |
| Duration (year-month-day) | from 2017-05-01 to 2019-04-30 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | IPATIMUP - INSTITUTO DE PATOLOGIA E IMUNOLOGIA MOLECULAR DA UNIVERSIDADE DO PORTO PCUP | PT (PORTO) | coordinator | 148˙635.00 |
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Project objective
Gastric cancer is an important health problem, being the fifth most common cancer and the third leading cause of cancer death. Its late diagnosis accompanied with a bad prognosis keeps this malignancy among the most deadly. After generations of cancer therapy based on chemical drugs causing severe side effects and limited efficiency, cancer treatment undergoes a paradigm shift towards targeted therapy, employing both monoclonal antibodies and small molecule inhibitors of receptor tyrosine kinase activity, as the most promising tool for the years to come. However, there are numerous patients that do not respond to these novel treatments due to mutations in downstream signalling pathways or to undefined molecular mechanisms. Protein glycosylation has been shown to modulate cellular receptor functions and alter antibody binding affinities and therefore foreshadows to play a major role in cancer therapy resistance. The GlycoModels project aims to identify glycan alterations on cell receptors that lead to targeted therapy resistance of gastric tumours. Using cutting-edge gene editing techniques, gastric cancer cell lines will be glyco-engineered to express hallmark glycan epitopes and applied in 3D-culture systems as advanced models mimicking the tumour microenvironment. These 3D-GlycoModels will display differential response to treatment with the most promising targeted therapy agents for key cell receptors (HER2, VEGFR, MET and RON) involved in growth, progression, and spread of cancer. In-depth analysis of the GlycoModels, covering glycan characterisation of the cell receptors, disclosing activated signalling pathways, and transcriptomics will unveil our understanding on driving mechanisms in therapy resistance and the glycosylation patterns involved. The structural validation of these glycoforms in human samples will deliver new biomarkers to be used in personalised therapy selection and thus, improve the outcome of advanced gastric cancer patients.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2018 |
Amanda P. B. Albuquerque, Meritxell Balmaña, Celso A. Reis, Eduardo I.C. Beltrão Identification of appropriate housekeeping genes for quantitative RT-PCR analysis in MDA-MB-231 and NCI-H460 human cancer cell lines under hypoxia and serum deprivation published pages: , ISSN: 2616-3632, DOI: 10.31083/j.jmcm.2018.03.001 |
Journal of Molecular and Clinical Medicine 1/3 | 2019-09-25 |
| 2019 |
Stefan Mereiter, Ãlvaro M. Martins, Catarina Gomes, Meritxell Balmaña, Joana A. Macedo, Karol Polom, Franco Roviello, Ana Magalhães, Celso A. Reis Oâ€glycan truncation enhances cancerâ€related functions of CD 44 in gastric cancer published pages: , ISSN: 0014-5793, DOI: 10.1002/1873-3468.13432 |
FEBS Letters | 2019-09-25 |
| 2018 |
Meritxell Balmaña, Stefan Mereiter, Francisca Diniz, Tália Feijão, Cristina Barrias, Celso Reis Multicellular Human Gastric Cancer Spheroids Mimic the Glycosylation Phenotype of Gastric Carcinomas published pages: 2815, ISSN: 1420-3049, DOI: 10.3390/molecules23112815 |
Molecules 23/11 | 2019-09-25 |
| 2019 |
Daniela Freitas, Meritxell Balmaña, Juliana Poças, Diana Campos, Hugo Osório, Andriana Konstantinidi, Sergey Y. Vakhrushev, Ana Magalhães, Celso A. Reis Different isolation approaches lead to diverse glycosylated extracellular vesicle populations published pages: 1621131, ISSN: 2001-3078, DOI: 10.1080/20013078.2019.1621131 |
Journal of Extracellular Vesicles 8/1 | 2019-09-25 |
| 2018 |
Joana G. Rodrigues, Meritxell Balmaña, Joana A. Macedo, Juliana Poças, Ângela Fernandes, Julio Cesar M. de-Freitas-Junior, Salomé S. Pinho, Joana Gomes, Ana Magalhães, Catarina Gomes, Stefan Mereiter, Celso A. Reis Glycosylation in cancer: Selected roles in tumour progression, immune modulation and metastasis published pages: , ISSN: 0008-8749, DOI: 10.1016/j.cellimm.2018.03.007 |
Cellular Immunology | 2019-09-25 |
| 2017 |
Henrique Duarte, Meritxell Balmaña, Stefan Mereiter, Hugo Osório, Joana Gomes, Celso Reis Gastric Cancer Cell Glycosylation as a Modulator of the ErbB2 Oncogenic Receptor published pages: 2262, ISSN: 1422-0067, DOI: 10.3390/ijms18112262 |
International Journal of Molecular Sciences 18/11 | 2019-09-25 |
| 2018 |
Amanda P.B. Albuquerque, Meritxell Balmaña, Stefan Mereiter, Filipe Pinto, Celso A. Reis, Eduardo I.C. Beltrão Hypoxia and serum deprivation induces glycan alterations in triple negative breast cancer cells published pages: 661-672, ISSN: 1431-6730, DOI: 10.1515/hsz-2018-0121 |
Biological Chemistry 399/7 | 2019-09-25 |
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