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GlycoModels

3D glyco-engineered models to address the role of glycosylation in gastric cancer clinical management

Total Cost €

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EC-Contrib. €

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Partnership

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 GlycoModels project word cloud

Explore the words cloud of the GlycoModels project. It provides you a very rough idea of what is the project "GlycoModels" about.

ron    lines    downstream    alter    receptors    tyrosine    small    patients    causing    samples    glycan    outcome    treatments    death    affinities    tumour    display    cancer    microenvironment    human    driving    drugs    treatment    disclosing    alterations    monoclonal    severe    met    resistance    tool    gene    fifth    molecular    techniques    antibody    shift    antibodies    unveil    vegfr    progression    binding    editing    efficiency    validation    accompanied    paradigm    deadly    gastric    3d    her2    employing    spread    activated    bad    mutations    chemical    personalised    undefined    patterns    undergoes    cellular    hallmark    keeps    express    mimicking    epitopes    functions    glycosylation    mechanisms    signalling    malignancy    health    cell    kinase    structural    therapy    foreshadows    culture    differential    glycoforms    limited    edge    play    modulate    generations    tumours    shown    diagnosis    inhibitors    cutting    molecule    biomarkers    transcriptomics    characterisation    glyco    engineered    receptor    prognosis    protein    agents    models    glycomodels   

Project "GlycoModels" data sheet

The following table provides information about the project.

Coordinator
IPATIMUP - INSTITUTO DE PATOLOGIA E IMUNOLOGIA MOLECULAR DA UNIVERSIDADE DO PORTO PCUP 

Organization address
address: RUA JULIO AMARAL DE CARVALHO 45
city: PORTO
postcode: 4200 135
website: http://www.ipatimup.pt

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Portugal [PT]
 Project website http://portal.i3s.up.pt/docs/mbalmana/1560417923482MBalmanawebsitereportpdf.pdf
 Total cost 148˙635 €
 EC max contribution 148˙635 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-05-01   to  2019-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    IPATIMUP - INSTITUTO DE PATOLOGIA E IMUNOLOGIA MOLECULAR DA UNIVERSIDADE DO PORTO PCUP PT (PORTO) coordinator 148˙635.00

Map

 Project objective

Gastric cancer is an important health problem, being the fifth most common cancer and the third leading cause of cancer death. Its late diagnosis accompanied with a bad prognosis keeps this malignancy among the most deadly. After generations of cancer therapy based on chemical drugs causing severe side effects and limited efficiency, cancer treatment undergoes a paradigm shift towards targeted therapy, employing both monoclonal antibodies and small molecule inhibitors of receptor tyrosine kinase activity, as the most promising tool for the years to come. However, there are numerous patients that do not respond to these novel treatments due to mutations in downstream signalling pathways or to undefined molecular mechanisms. Protein glycosylation has been shown to modulate cellular receptor functions and alter antibody binding affinities and therefore foreshadows to play a major role in cancer therapy resistance. The GlycoModels project aims to identify glycan alterations on cell receptors that lead to targeted therapy resistance of gastric tumours. Using cutting-edge gene editing techniques, gastric cancer cell lines will be glyco-engineered to express hallmark glycan epitopes and applied in 3D-culture systems as advanced models mimicking the tumour microenvironment. These 3D-GlycoModels will display differential response to treatment with the most promising targeted therapy agents for key cell receptors (HER2, VEGFR, MET and RON) involved in growth, progression, and spread of cancer. In-depth analysis of the GlycoModels, covering glycan characterisation of the cell receptors, disclosing activated signalling pathways, and transcriptomics will unveil our understanding on driving mechanisms in therapy resistance and the glycosylation patterns involved. The structural validation of these glycoforms in human samples will deliver new biomarkers to be used in personalised therapy selection and thus, improve the outcome of advanced gastric cancer patients.

 Publications

year authors and title journal last update
List of publications.
2018 Amanda P. B. Albuquerque, Meritxell Balmaña, Celso A. Reis, Eduardo I.C. Beltrão
Identification of appropriate housekeeping genes for quantitative RT-PCR analysis in MDA-MB-231 and NCI-H460 human cancer cell lines under hypoxia and serum deprivation
published pages: , ISSN: 2616-3632, DOI: 10.31083/j.jmcm.2018.03.001
Journal of Molecular and Clinical Medicine 1/3 2019-09-25
2019 Stefan Mereiter, Álvaro M. Martins, Catarina Gomes, Meritxell Balmaña, Joana A. Macedo, Karol Polom, Franco Roviello, Ana Magalhães, Celso A. Reis
O‐glycan truncation enhances cancer‐related functions of CD 44 in gastric cancer
published pages: , ISSN: 0014-5793, DOI: 10.1002/1873-3468.13432
FEBS Letters 2019-09-25
2018 Meritxell Balmaña, Stefan Mereiter, Francisca Diniz, Tália Feijão, Cristina Barrias, Celso Reis
Multicellular Human Gastric Cancer Spheroids Mimic the Glycosylation Phenotype of Gastric Carcinomas
published pages: 2815, ISSN: 1420-3049, DOI: 10.3390/molecules23112815
Molecules 23/11 2019-09-25
2019 Daniela Freitas, Meritxell Balmaña, Juliana Poças, Diana Campos, Hugo Osório, Andriana Konstantinidi, Sergey Y. Vakhrushev, Ana Magalhães, Celso A. Reis
Different isolation approaches lead to diverse glycosylated extracellular vesicle populations
published pages: 1621131, ISSN: 2001-3078, DOI: 10.1080/20013078.2019.1621131
Journal of Extracellular Vesicles 8/1 2019-09-25
2018 Joana G. Rodrigues, Meritxell Balmaña, Joana A. Macedo, Juliana Poças, Ângela Fernandes, Julio Cesar M. de-Freitas-Junior, Salomé S. Pinho, Joana Gomes, Ana Magalhães, Catarina Gomes, Stefan Mereiter, Celso A. Reis
Glycosylation in cancer: Selected roles in tumour progression, immune modulation and metastasis
published pages: , ISSN: 0008-8749, DOI: 10.1016/j.cellimm.2018.03.007
Cellular Immunology 2019-09-25
2017 Henrique Duarte, Meritxell Balmaña, Stefan Mereiter, Hugo Osório, Joana Gomes, Celso Reis
Gastric Cancer Cell Glycosylation as a Modulator of the ErbB2 Oncogenic Receptor
published pages: 2262, ISSN: 1422-0067, DOI: 10.3390/ijms18112262
International Journal of Molecular Sciences 18/11 2019-09-25
2018 Amanda P.B. Albuquerque, Meritxell Balmaña, Stefan Mereiter, Filipe Pinto, Celso A. Reis, Eduardo I.C. Beltrão
Hypoxia and serum deprivation induces glycan alterations in triple negative breast cancer cells
published pages: 661-672, ISSN: 1431-6730, DOI: 10.1515/hsz-2018-0121
Biological Chemistry 399/7 2019-09-25

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