Opendata, web and dolomites

MicroWars SIGNED

The Evolution of Bacterial Warfare

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 MicroWars project word cloud

Explore the words cloud of the MicroWars project. It provides you a very rough idea of what is the project "MicroWars" about.

experiments    pseudomonas    combination    battlegrounds    weaponry    evolve    techniques    reluctant    experimental    generally    cryomicroscopy    aggression    protein    combining    evolution    predictions    fight    microbiome    why    asking    free    co    extremely    coli    time    animals    levels    attack    biology    simply    employ    neighbours    mammalian    competitors    possess    cutting    risk    competitive    combat    extreme    group    bacteria    germ    proven    animal    individual    examine    first    microscopy    host    machines    electron    genetics    escherichia    communities    release    holes    mouse    punch    launch    competition    poisoned    bacterial    fluorescence    questions    evolutionary    complexity    behaviours    molecular    tactics    aggressive    stab    confocal    assemble    game    perspective    influence    literature    weapons    meet    genomics    commit    suicide    species    edge    cells    position    clear    ecology    theory    image    watched    ecological    freestyle    microfluidics    warfare    aeruginosa    model    intense    spears    many   

Project "MicroWars" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD 

Organization address
address: WELLINGTON SQUARE UNIVERSITY OFFICES
city: OXFORD
postcode: OX1 2JD
website: www.ox.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 2˙750˙137 €
 EC max contribution 2˙750˙137 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-ADG
 Funding Scheme ERC-ADG
 Starting year 2018
 Duration (year-month-day) from 2018-10-01   to  2023-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD UK (OXFORD) coordinator 2˙750˙137.00

Map

 Project objective

Many bacteria are extremely aggressive. They assemble poisoned molecular spears to stab neighbours, they release protein machines that punch holes in competitors and, moreover, some cells will commit suicide in order to launch their attack. While there is a large literature on the evolution of combat and competition in animals, this has focused on why animals are generally reluctant to fight. The evolution of extreme aggression in bacteria, therefore, challenges our current understanding of competition in biology. I will develop bacterial warfare as a model for competitive behaviour by asking three key questions that each build in complexity: 1) Why do weapons evolve? 2) What tactics do bacteria use during combat and why? 3) How does ecological complexity influence the value and use of weapons? My group will examine these questions theoretically and test our predictions using two model species, Escherichia coli and Pseudomonas aeruginosa, which possess very different levels of weaponry. The project has risk and challenges in that bacterial behaviours cannot simply be watched like animal behaviours. To meet these, we will employ a proven combination of individual-based modelling, game theory, competition experiments, experimental evolution, confocal microscopy, molecular genetics, genomics and germ-free mouse work. We will also co-develop new techniques. Freestyle microfluidics will position bacteria and weaponry for study; electron fluorescence cryomicroscopy will image, for the first time, bacterial battlegrounds at the molecular scale. By combining cutting-edge methods with clear evolutionary questions, I aim to provide a major new perspective on combat, and on bacteria. There is currently an intense interest in how bacteria establish in host-associated communities, including the mammalian microbiome. Understanding this will need a new focus on the evolution, and ecology, of bacterial warfare.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "MICROWARS" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "MICROWARS" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

NeuroMag (2019)

The Neurological Basis of the Magnetic Sense

Read More  

IMPACCT (2019)

Improved Patient Care by Combinatorial Treatment

Read More  

Life-Inspired (2019)

Life-inspired complex molecular systems controlled by enzymatic reaction networks

Read More