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Keeping nodules in check: Interplay of rhizobial and host factors controlling nodule morphogenesis and identity in legume plants.

Total Cost €


EC-Contrib. €






 Nod2Root project word cloud

Explore the words cloud of the Nod2Root project. It provides you a very rough idea of what is the project "Nod2Root" about.

cell    hosts    lacking    bradyrhizobium    nodule    molecular    wp1    genetics    fusions    soybean    rhizobial    nodules    pointing    wp3    regulation    mutants    metabolic    formed    found    truncatula    signalling    conversion    decipher    persistence    bacteria    origin    insights    networks    organs    genes    morphogenetic    coch    attempts    roots    diazoefficiens    elicited    pisum    unravel    identity    light    repressing    former    legumes    combine    metabolomics    metabolites    ectopic    wp2    combination    plants    recognition    transcriptomics    mechanisms    medicago    underlying    nodulation    interestingly    stress    economically    fixation    place    specialized    sativum    altogether    takes    checkpoint    delta    orthologs    rhizobia    ongoing    tip    group    gene    determinate    engineer    deep    nbcl    root    symbiotic    unravelled    noot    integrity    mutant    reporter    cellular    determinants    maintained    legume    ecfg    organogenesis    host    cells    bop    plant    sigma    nitrogen    model    biology   

Project "Nod2Root" data sheet

The following table provides information about the project.


Organization address
address: Raemistrasse 101
postcode: 8092

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Project website
 Total cost 187˙419 €
 EC max contribution 187˙419 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-03-01   to  2019-02-28


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Symbiotic nitrogen fixation by rhizobia takes place in specialized organs of legume host plants, the root nodules. While rather deep molecular insights into plant-rhizobia recognition, early nodule organogenesis, regulation of nodulation and nitrogen fixation are available, much less is known about how nodule integrity is maintained and the origin of the underlying morphogenetic program. Recently, NOOT BOP COCH LIKE (NBCL) genes of Medicago truncatula and Pisum sativum were found to ensure nodule integrity by repressing ectopic root formation (applicant's former project). Interestingly, soybean nodules elicited by a Bradyrhizobium diazoefficiens mutant lacking the general stress response sigma factor σEcfG also formed ectopic roots (host's project), pointing to a bacteria-plant signalling system that is crucial for nodule persistence and integrity. Here, we propose to decipher the molecular determinants that maintain determinate nodule identity using the B. diazoefficiens – soybean model. We will combine plant molecular genetics, cell biology with transcriptomics and metabolomics to unravel cells, genes and metabolic networks that contribute to the checkpoint system ensuring nodule integrity. In work package 1 (WP1), the role of three soybean NBCL orthologs will be unravelled. In WP2, the nodule-to-root conversion characteristic for B. diazoefficiens ΔecfG mutants will be studied at the cellular level using root tip-specific reporter fusions. In WP3, a combination of metabolomics and transcriptomics will be applied to identify metabolites and gene networks involved in the nodule-to-root conversion elicited by ΔecfG and nbcl mutants. Altogether, results of this project will provide insight into determinants and mechanisms used by the economically important group of soybean plants to maintain the integrity of specialized, root-derived organs, an aspect that is relevant also in the light of ongoing attempts to engineer non-legumes into rhizobial hosts.

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The information about "NOD2ROOT" are provided by the European Opendata Portal: CORDIS opendata.

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