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INFORM SIGNED

Innovative Electrochemical Multiplex Biosensor for Detection and Quantification of Clinically Relevant Circulating miRNAs

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 INFORM project word cloud

Explore the words cloud of the INFORM project. It provides you a very rough idea of what is the project "INFORM" about.

elevated    microrna    fm    imprecision    curative    mirna    fatal    staging    intermediate    threatening    detect    biological    discrimination    tumours    issue    overexpressed    psa    quantify    biosensor    accurate    sub    assays    had    electrochemical    decision    suggesting    diagnosis    operatory    preoperative    serum    selectivity    malignant    distant    spread    sensitivity    disease    radical    medicine    cancer    highlighting    earlier    local    personalised    detection    localised    inform    prostatectomy    validation    differentiate    prostate    50    examination    post    submitted    sandwich    potentially    shown    stage    indolent    optimisation    risk    informed    patients    circulating    biopsy    quantification    panel    multiplex    undetectable    spreading    imaging    metastatic    rely    antigen    doctor    profiling    clinically    fail    medical    photoelectrochemical    pca    innovative    life    surgery    interventioned    amounts    histopathological    treatment    procedure    mirnas    class    biomarkers    disseminated    coding   

Project "INFORM" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITEIT ANTWERPEN 

Organization address
address: PRINSSTRAAT 13
city: ANTWERPEN
postcode: 2000
website: www.ua.ac.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 178˙320 €
 EC max contribution 178˙320 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2021-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITEIT ANTWERPEN BE (ANTWERPEN) coordinator 178˙320.00

Map

 Project objective

Radical prostatectomy is currently the most used curative procedure in the treatment of localised prostate cancer (PCa). However, in 30-50% of interventioned patients Prostate Specific Antigen (PSA) increases on post-operatory, meaning that the cancer has spread. The rise in PSA is due to imprecision in preoperative staging, suggesting patients already had distant, undetectable disease. Another issue is that elevated serum PSA is not specific to malignant prostate disease, it cannot differentiate between indolent tumours or those that are/will become life threatening. Fatal cancer is most often due to metastatic disease but histopathological examination of biopsy or traditional imaging methods fail to detect the early disseminated circulating biological information highlighting the need for approaches that can detect biomarkers of cancer spreading at an early stage. Circulating amounts of non-coding microRNA (miRNA) have been shown to have a biological impact and to be clinically associated with cancer and are now seen as a new class of biomarkers that will allow earlier and more accurate diagnosis. The objective of INFORM is to develop an innovative electrochemical multiplex biosensor for detection and quantification of a panel of clinically relevant circulating miRNAs in intermediate-risk PCa patients that will be submitted to potentially curative surgery. By focusing on the development, optimisation and validation of a biosensor for miRNA profiling in PCa, discrimination of patients with local disease from those with more advanced PCa will be possible. The biosensor will rely on the selectivity of the sandwich assays and on the sensitivity of the photoelectrochemical detection to quantify, at the sub-fM level, circulating miRNAs that are associated with PCa. The quantification of these overexpressed miRNAs will lead to a better overall management of the disease and allow for a more informed decision by the medical doctor, providing personalised medicine.

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The information about "INFORM" are provided by the European Opendata Portal: CORDIS opendata.

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