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FIMBUG SIGNED

Heterogeneity in fimbrial length and abundance as a generic regulator of E. coli surface colonization

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 FIMBUG project word cloud

Explore the words cloud of the FIMBUG project. It provides you a very rough idea of what is the project "FIMBUG" about.

length    chemical    hypothesis    fitter    influence    biomaterial    care    loose    herein    mobile    forming    certain    bonds    spreading    introduce    biological    bacteria    contributor    biofilm    reflected    scientific    hair    regulatory    environmental    roles    suggests    niches    mean    modes    true    movement    bacterium    colonizers    player    nanopatterned    antibiotic    actions    colloidal    heterogeneous    resistance    basis    read    binding    firm    expression    3d    recording    necessarily    bacterial    adhesion    physical    immobile    subsequent    monovalent    tracking    difficult    adjust    simultaneous    found    foresee    interactions    health    colonization    fimbriae    multivalent    shifting    structures    organelles    regulate    interplay    modern    career    attributed    function    intricate    surface    single    fimbrial    training    surfaces    unraveling    flow    implant    understand    infections    overarching    eradicate    mechanisms    mechanism    host    unexplored   

Project "FIMBUG" data sheet

The following table provides information about the project.

Coordinator
GOETEBORGS UNIVERSITET 

Organization address
address: VASAPARKEN
city: GOETEBORG
postcode: 405 30
website: www.gu.se

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 185˙857 €
 EC max contribution 185˙857 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-01-01   to  2019-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    GOETEBORGS UNIVERSITET SE (GOETEBORG) coordinator 185˙857.00

Map

 Project objective

The aim of my research is to identify generic and physical mechanisms that regulate bacterial colonization and subsequent biofilm formation on biomaterial surfaces. This is an emerging problem in modern health care since biofilm implant-related infections are very difficult to eradicate and thus a main contributor to the development and spreading of antibiotic resistance. A key player is fimbriae; these hair-like surface organelles found on many bacteria are known to strongly promote biofilm formation, which is commonly attributed to fimbriae forming strong surface bonds. By recording in 3D the binding of single bacteria to nanopatterned surfaces we observed that this is not necessarily true; We found that fimbriae due to their heterogeneous distribution in length, rather then forming strong bonds provide bacteria a mean to adjust their surface adhesion, shifting between monovalent, loose and mobile binding to firm multivalent immobile binding modes in response to different flow conditions. This suggests a so far unexplored, regulatory role of fimbriae in the surface colonization process. My overarching aim is therefore to understand the influence of this mechanism on bacterial surface colonization. Specifically, I will test the hypothesis that physical and chemical/colloidal interactions are reflected in these structures and their biological function, providing bacteria evolved roles; In this case, that bacteria with certain fimbrial expression are fitter to be colonizers of certain environmental niches. To investigate this I will introduce new methods, allowing simultaneous read-out of a single-bacterium fimbrial expression and tracking of its movement in 3D. I foresee that this project and the training actions described herein will be the basis for a future scientific career focused on unraveling the intricate interplay between bacteria and their host surfaces.

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The information about "FIMBUG" are provided by the European Opendata Portal: CORDIS opendata.

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